Uroflowmetry Results and Vitamin D Levels

The Relationship Between Vitamin D Level and Lower Urinary Tract Symptoms in Women

The investigators aimed to evaluate the relationship between LUTS and vitamin D with uroflowmetry parameters in female patients. They found no relation between vitamin D levels and LUTS in respect to uroflowmetry. However, in low vitamin D patients, Ca is related with urologic problems. The investigators believe that there is a need for studies emphasizing serum Ca levels in addition to vitamin D levels in patients with LUTS.

Study Overview

• Status: Completed
• Conditions: Lower Urinary Tract Symptoms; Vitamin D Deficiency; Calcium Deficiency

Detailed Description

This retrospective cohort study included 186 female patients who admitted to LUTS. Demographic characteristics, medical history, calcium (Ca) and vitamin D including laboratory studies and uroflowmetry results as maximum urine flow rate (Qmax), average urine flow rate (Qav), and voided volume (V) were recorded. Patients were divided into two groups according to age (18-50 and ≥51) and vitamin D levels (<20 and ≥20).

Laboratory parameters, uroflowmetry results, were compared between groups.

The study was approved by the local ethics committee (approval#22/06/2018-09.29-54132726-000-14136). The study was conducted in accordance to the Helsinki Declaration and Good Clinical Practices Guidelines.

• Study Type: Observational
• Enrollment (Actual): 186

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 50 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Female

• Sampling Method: Probability Sample

Study Population

Female patients with low urinary tract symptoms.

Description

Inclusion Criteria:

Clinical diagnosis of low urinary tract symptom

Exclusion Criteria:

Urinary tract infection, Diabetes mellitus, Neurological disorder, Pregnancy Stone disease Other urinary system disorders.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Uroflowmetry Results	There was no significant relationship between age, creatinine, Qmax, Qav, V and vitamin D level (P>0.05).	12 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Vitamin D Levels	The mean D vitamin level was 21.19ng/ml. D vitamin was <20 ng/ml in %55.9 patients. There was no difference in the levels according to the age of all patients.	12 months

Collaborators and Investigators

• Sponsor: Umraniye Education and Research Hospital

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2017
• Primary Completion (Actual): December 30, 2017
• Study Completion (Actual): December 30, 2017

Study Registration Dates

• First Submitted: May 9, 2020
• First Submitted That Met QC Criteria: May 26, 2020
• First Posted (Actual): May 28, 2020

Study Record Updates

• Last Update Posted (Actual): June 1, 2020
• Last Update Submitted That Met QC Criteria: May 29, 2020
• Last Verified: May 1, 2020

More Information

Terms related to this study

• Keywords: Lower Urinary Tract Symptoms; Vitamin D Deficiency; Calcium Deficiency
• Additional Relevant MeSH Terms: Urological Manifestations; Nutrition Disorders; Avitaminosis; Deficiency Diseases; Malnutrition; Vitamin D Deficiency; Lower Urinary Tract Symptoms
• Other Study ID Numbers: UmraniyeERH

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No