Allergy to Almond in Children

Allergy to Almond in Children: Diagnostic Values and Severity

Allergy to tree nuts are frequent in children but allergy to almond is one of the less described tree nuts allergy. The main objective of our study is to determine diagnostic values of skin prick-tests and specific IgE to almond in a population of children sensitized to almond and challenged in our unit from november 2013 to march 2020.

Study Overview

• Status: Unknown
• Conditions: Food Allergy in Children
• Intervention / Treatment: Diagnostic test: skin prick-test

Detailed Description

Secondary objectives are

• description of allergic reactions to almond (symptoms, severity)
• modelisation of eliciting dose to almond in our population
• evaluation of the association between atopic comorbidities and allergy to almond in children sensitized to almond
• evaluation of the association between allergy to almond and the importance of skin and sIgE sensitization

• Study Type: Observational
• Enrollment (Anticipated): 50

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 1 year to 18 years (Child, Adult)
• Accepts Healthy Volunteers: N/A
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

children sensitized to almond and challenged in our unit

Description

Inclusion Criteria:

• oral food challenge to almond performed in the pediatric allergy department of the University Hospital of Nancy from november 2013 and march 2020

Exclusion Criteria:

• doubtful or incomplete oral food challenge to almond

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Retrospective

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
diagnostic values of skin prick-test and sIgE to almond	BASELINE

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
allergic reactions during oral food challenge	symptoms and severity	BASELINE
eliciting doses to almond	ED05, ED10 and ED50	BASELINE
atopic comorbidities	respiratory allergies, other food allergies, asthma	BASELINE

Collaborators and Investigators

• Sponsor: Central Hospital, Nancy, France

Study record dates

Study Major Dates

• Study Start (Anticipated): July 20, 2020
• Primary Completion (Anticipated): August 31, 2020
• Study Completion (Anticipated): September 7, 2020

Study Registration Dates

• First Submitted: May 25, 2020
• First Submitted That Met QC Criteria: May 25, 2020
• First Posted (Actual): May 29, 2020

Study Record Updates

• Last Update Posted (Actual): July 21, 2020
• Last Update Submitted That Met QC Criteria: July 20, 2020
• Last Verified: May 1, 2020

More Information

Terms related to this study

• Keywords: children; almond; allergy; atopy; tree nuts
• Additional Relevant MeSH Terms: Immune System Diseases; Hypersensitivity, Immediate; Hypersensitivity; Food Hypersensitivity
• Other Study ID Numbers: 2020PI100

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No