The Next Leap in Cardiac Magnetic Resonance Imaging:Cycling the Field (TITAN)

May 12, 2023 updated by: University of Aberdeen

The Next Leap in Cardiac Magnetic Resonance Imaging:Cycling the Field The TITAN Study

The main aim of the study is to build and test a cardiac-specific coil purposely assembled in house to suit the FFC-MRI whole-body prototype and to test if it could be used for clinical cardiac scans in human subject populations.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Detailed Description

Aberdeen scientists are at the forefront of a new type of magnetic resonance imaging (MRI), having built in-house the only two available prototypes of Fast Field-Cycling MRI in the world - and these already have clinical imaging capabilities. Fast Field-Cycling MRI switches rapidly over a range of field strengths (0.2 T to 200 µT), providing a T1 dispersion curve. This information is invisible to fixed-field scanners and uncovers unique knowledge about motion and interaction between component molecules within a tissue (i.e. water/fat/proteins). In this application the investigators wish to use their in-house expertise further to extend the capability of our Fast Field-Cycling MRI to perform cardiac imaging by building the first-ever cardiac Fast Field-Cycling MRI coil and develop cardiac pulse sequences with ECG gating. The investigators will aim to establish the normalcy of T1 dispersion curves for left ventricular myocardium in healthy volunteers, and further on to distinguish the characteristics of post-myocardial infarction scar T1 dispersion curves.

Study Type

Interventional

Enrollment (Anticipated)

150

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

  • United Kingdom
    • Aberdeenshire
      • Aberdeen, Aberdeenshire, United Kingdom, AB25 2ZD
        • Recruiting
        • Cardiovascular Research Facility
        • Contact:
        • Contact:
      • Aberdeen, Aberdeenshire, United Kingdom, AB25 2ZD
        • Recruiting
        • University of Aberdeen and NHS Grampian
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

20 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Participant who is willing and able to give informed consent for participation in the study
  • Healthy volunteers willing to give informed consent for participation in the study
  • Patients diagnosed with a previous myocardial infarction

Exclusion Criteria:

  • Unwillingness to participate
  • Claustrophobia
  • Contraindication to MRI scanning such as implantable cardiac devices
  • Participants who have had a previous myocardial infarction in the past of which they may not be aware and this is discovered whilst being scanned on the 3T MRI scanner, or who may have any other cardiology condition that they were previously unaware will not be included in the healthy control group, even if they present themselves to us as "healthy" at the time of the study visit
  • Pregnancy
  • Body habitus that may preclude comfortable positioning of the volunteer in either of the MRI scanners (>50cm in diameter)
  • Participants with abnormal kidney function that will preclude them from receiving a contrast agent

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Non-Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Healthy Volunteers
Procedure: Cardiac Magnetic Resonance Imaging
Cardiac Magnetic Resonance Imaging - Cardiac Scan
Procedure: Fast Field Cycling - Magnetic Resonance Imaging
Fast Field Cycling - Magnetic Resonance Imaging Cardiac Scan
Procedure: Electrocardiogram
Electrocardiogram
Other Names:
  • ECG
Procedure: Echocardiogram
Echocardiogram
Experimental: Myocardial Infarction Group
Patients diagnosed with a myocardial infarction
Procedure: Cardiac Magnetic Resonance Imaging
Cardiac Magnetic Resonance Imaging - Cardiac Scan
Procedure: Fast Field Cycling - Magnetic Resonance Imaging
Fast Field Cycling - Magnetic Resonance Imaging Cardiac Scan

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Cardiac Magnetic Resonance Imaging
Time Frame: At baseline
Cardiac Magnetic Resonance Imaging - Cardiac Scan to assess cardiac function and T1 dispersion curves
At baseline
Fast Field Cycling Magnetic Resonance Imaging
Time Frame: At baseline
Fast Field Cycling Magnetic Resonance Imaging - Cardiac Scan to assess cardiac function and T1 dispersion curves
At baseline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Aberdeen

Investigators

  • Principal Investigator: Dana Dawson, DPhil, University of Aberdeen

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

August 1, 2020

Primary Completion (Anticipated)

July 31, 2025

Study Completion (Anticipated)

July 31, 2025

Study Registration Dates

First Submitted

June 30, 2020

First Submitted That Met QC Criteria

July 2, 2020

First Posted (Actual)

July 7, 2020

Study Record Updates

Last Update Posted (Actual)

May 15, 2023

Last Update Submitted That Met QC Criteria

May 12, 2023

Last Verified

May 1, 2023

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2-010-20

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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