Resolvin D1 Levels in Patients With Periodontitis

August 17, 2020 updated by: Ceren Gökmenoğlu, T.C. ORDU ÜNİVERSİTESİ

The Role of Resolvin D1 in Maintaining Oral Health

The purpose of the study was to determine the levels of Resolvin D1 (RVD1) in the gingival crevicular fluid (GCF) and saliva of the patients with periodontitis (P) and also to investigate the effects of non-surgical periodontal treatments (NSPTs) on its levels.

A total of 26 subjects (15 P, 11 healthy) were included. Clinical periodontal measurements, GCF and saliva samples were collected from each individual at baseline and 1 month after NSPTs in P group. RVD1 levels were determined by enzyme-linked immunosorbent assay (ELISA) method.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

26

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey
      • Ordu, Turkey, 52200
        • Ordu university

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

30 years to 60 years (ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Stage 3, Grade B and generalized periodontitis patients

Exclusion Criteria:

  • excessive forces;
  • presence of systemic diseases
  • administration of non-steroidal and anti-inflammatory drugs or antibiotic therapies within the previous 6 months
  • having received non-surgical periodontal treatment within the past 6 months
  • allergy or sensitivity to any drug,
  • pregnancy, lactation
  • current and former use of tobacco.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: DIAGNOSTIC
  • Allocation: NON_RANDOMIZED
  • Interventional Model: PARALLEL
  • Masking: NONE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
ACTIVE_COMPARATOR: Periodontitis patients
gingival crevicular fluid and saliva collection were taken before and after nonsurgical periodontal treatment
Procedure: periodontal therapy
Non surgical periodontal therapy was performed to patients with peridontitis
NO_INTERVENTION: Healthy individuals
gingival crevicular fluid and saliva collection were taken at baseline after oral hygiene instructions

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Biochemical parameter (resolvin D1)
Time Frame: Baseline and 1 month after NSPT
The changes in levels of resolvin D1 after periodontal treatment determined by ELISA.
Baseline and 1 month after NSPT

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Probing pocket depth
Time Frame: Baseline and 1 month after NSPT
The changes in probing pocket depth after periodontal treatment were evaluated
Baseline and 1 month after NSPT
Clinical attachment level (CAL)
Time Frame: Baseline and 1 month after NSPT
The changes in CAL after periodontal treatment were evaluated
Baseline and 1 month after NSPT
Plaque index (PI)
Time Frame: Baseline and 1 month after NSPT
The changes in PI after periodontal treatment were evaluated
Baseline and 1 month after NSPT
Gingival index (GI)
Time Frame: Baseline and 1 month after NSPT
The changes in GI after periodontal treatment were evaluated
Baseline and 1 month after NSPT

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

T.C. ORDU ÜNİVERSİTESİ

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (ACTUAL)

July 31, 2019

Primary Completion (ACTUAL)

February 29, 2020

Study Completion (ACTUAL)

February 29, 2020

Study Registration Dates

First Submitted

July 29, 2020

First Submitted That Met QC Criteria

July 29, 2020

First Posted (ACTUAL)

August 3, 2020

Study Record Updates

Last Update Posted (ACTUAL)

August 19, 2020

Last Update Submitted That Met QC Criteria

August 17, 2020

Last Verified

August 1, 2020

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Ordu University Dental Faculty

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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