Lung Function After Abdominal Surgery

Hypoxia, Lung Function and Diffusion Capacity After Abdominal Surgery

The study aims to investigate changes in lung function and diffusion capacity for carbon monoxide after open and minimally invasive abdominal surgery and whether such changes can explain hypoxia after surgery.

Inclusion: Patients undergoing surgery for abdominal surgery

Exclusion: Dementia or cognitive impairment that makes it impossible to participate in studies.

Investigation: The day before surgery and the day after surgery

Primary outcome measures:

• Pulmonary function test with dynamic spirometry (Vital capacity, FEV1) and diffusion capacity for carbon monoxide.
• PaO2, PaCO2 and oxygen saturation (blood gas)

Study Overview

• Status: Completed
• Conditions: Postoperative Complications; Abdominal Surgery; Lung Function
• Intervention / Treatment: Diagnostic test: Lung function before and after surgery

Detailed Description

Postoperative hypoxia complicates 30% - 50% of abdominal surgeries. People at particular risk for postoperative pulmonary complications including severe hypoxia are those who undergo abdominal surgery, emergency surgery or have a respiratory failure due to chronic lung disease including obstructive sleep apnea. The cause of postoperative restrictive lung function and hypoxia is unknown. Previous studies report that PaO2 decreases by an average of 2 kPa after abdominal surgery, while PaCO2 is unchanged and vital capacity decreases by 35%.

The study aims to investigate changes in lung function and diffusion capacity for carbon monoxide after open and minimally invasive abdominal surgery and whether such changes can explain hypoxia after surgery.

Design: Prospective cohort study

Inclusion: Patients undergoing surgery for abdominal surgery

Exclusion: Dementia or cognitive impairment that makes it impossible to participate in studies.

Method: The day before surgery and the day after surgery: Lung function (Vital capacity and FEV1) using box and diffusion capacity measurements and blood gas measurement

Primary outcome measures:

• Pulmonary function test with dynamic spirometry (Vital capacity, FEV1) and diffusion capacity for carbon monoxide.
• PaO2, PaCO2 and oxygen saturation (blood gas) Other variables examined: age, sex, height, weight, type of surgery, type of anesthesia, smoking status, length of surgery, previously known lung disease.

• Study Type: Observational
• Enrollment (Actual): 59

Contacts and Locations

Study Locations

• Sweden
  • Umeå, Sweden
    • Dept surgery,

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

patients of 18 years old or olderundergoing abdominal surgery at department of Surgery, Urology and Gynecologi Umeå University hospital

Description

Inclusion Criteria:

• Adult patients (18 years old and older) scheduled for surgery in the abdomen at department of Surgery, Urology and Gynecologi, Umeå University hospital.
• Must be able to perform a lung function test

Exclusion Criteria:

• Dementia or severe cognitive impairment

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Prospective

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Abdominal surgery; People who to be operated in the abdomen are investigated before and after surgery.	Diagnostic test: Lung function before and after surgery; A diagnostic test; Other Names: Diffusion capacity and arterial blood gas before and after surgery.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Diffusion capacity for carbon monoxide (DLCO)	Change in DLCO	Change from baseline (the day before surgery) to postoperative day 1 or 2

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Vital capacity (VC)	Change in VC	Change from baseline (the day before surgery) to postoperative day 1 or 2
Forced expiratory volume (FEV1)	Change in FEV1	Change from baseline (the day before surgery) to postoperative day 1 or 2
Arterial PO2	Change in arterial PO2	Change from baseline (the day before surgery) to postoperative day 1 or 2
Arterial PCO2	Change in arterial PCO2	Change from baseline (the day before surgery) to postoperative day 1 or 2

Collaborators and Investigators

• Sponsor: Umeå University
• Collaborators: Karolinska Institutet
• Investigators: Principal Investigator: Karl A Franklin, Prof, Inst Surgical and periopertive sciences, Umeå university, Sweden

Study record dates

Study Major Dates

• Study Start (Actual): August 17, 2020
• Primary Completion (Actual): October 17, 2021
• Study Completion (Actual): October 17, 2021

Study Registration Dates

• First Submitted: July 28, 2020
• First Submitted That Met QC Criteria: August 4, 2020
• First Posted (Actual): August 6, 2020

Study Record Updates

• Last Update Posted (Estimate): January 24, 2023
• Last Update Submitted That Met QC Criteria: January 21, 2023
• Last Verified: January 1, 2023

More Information

Terms related to this study

• Keywords: Postoperative complications; Lung function; Abdominal surgery; Diffusion capacity
• Additional Relevant MeSH Terms: Pathologic Processes; Postoperative Complications
• Other Study ID Numbers: 2018-223-31M

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No
• IPD Plan Description: We plan to share IPD if possible according to Swedish legislation

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No