Secondary Lymphedema Due to Human Adjuvant Disease

Human Adjuvant Disease as a Cause of Secondary Lower Extremity Lymphedema


Lead Sponsor: Hospital Angeles del Pedregal

Source Hospital Angeles del Pedregal
Brief Summary

This observational, descriptive, retrospective study the clinical and imaging findings of 10 lower legs of 5 patients with previous history of injection of modeling substances for cosmetic purposes at buttocks and hips ande developed lower limb edema. Lower limb lymphedema index and lymphoscintigraphy findings were evaluated and reported.

Detailed Description

Lymphoscintigraphy findings were reported with the Transport index (TI), were any value over 5 will represent abnormalities in lymphatic function.

Overall Status Completed
Start Date March 1, 2017
Completion Date December 1, 2017
Primary Completion Date July 1, 2017
Study Type Observational
Primary Outcome
Measure Time Frame
Transport Index 4 months
Secondary Outcome
Measure Time Frame
Lower extremity lymphedema index 4 months
Enrollment 5

Intervention Type: Diagnostic Test

Intervention Name: Lower extremity Lymphoscintigraphy

Description: Study of lymphoscintigraphy (LCG) abnormalities in a group of patients with history of infiltration of modeling substances in buttocks and hips and complain about lower extremities edema. LCG was performed and evaluated by a single nuclear medicine specialist through injection of the sulfur nanocolloid Technetium 99m, injected intradermal and interdigital in bilateral toes. Dynamic studies were requested for all patients. Standardized acquisition times at 15, 30, 60 and 120 minutes after injection were taken. The following parameters were considered to obtain the transport index in each pelvic limb: transport kinematics, distribution pattern, index time for the appearance of regional lymph nodes, number and collection of colloids in lymph nodes and presence and quality of the colloid uptake by the lymphatic vessels. Summation of these five components resulted in the transport index, which could range from 0 to 45 points


Sampling Method: Non-Probability Sample


Inclusion Criteria: - Both sex - Over 18 years old - History of injection of modelling substances for cosmetic purposes - History of lower limb edema Exclusion Criteria: - History of primary lower limb lymphedema - Reject to participate - Confirmed other causes of edema

Gender: All

Minimum Age: 18 Years

Maximum Age: 75 Years

Healthy Volunteers: Accepts Healthy Volunteers

Facility: Hospital Angeles Pedregal
Location Countries


Verification Date

October 2020

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Hospital Angeles del Pedregal

Investigator Full Name: javier lopez

Investigator Title: Principal investigator, Plastic and reconstructive surgeon staff, MBA, FACS

Has Expanded Access No
Condition Browse
Patient Data Yes
Study Design Info

Observational Model: Case-Only

Time Perspective: Retrospective