MRI Development for Radiotherapy Planning and Delivery in Non-Patient Volunteers (MINION)

Non-patient volunteers will be scanned on the MR-Linac and MRSIM to facilitate the development, optimisation and validation of MRI protocols at The Christie NHS Foundation Trust.

Study Overview

• Status: Recruiting
• Conditions: Focus of the Study is MRI Sequence Development

• Study Type: Observational
• Enrollment (Estimated): 500

Contacts and Locations

Study Locations

• United Kingdom
  • Manchester, United Kingdom
    • Recruiting
    • The Christie NHS FT
    • Contact: Cynthia Eccles, DPhil; Phone Number: 16187999; Email: cynhia.eccles1@nhs.net

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 16 years and older (Child, Adult, Older Adult)
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Personnel at The Christie NHS Foundation Trust

Description

Inclusion Criteria:

• Willing and able to provide written consent
• Volunteers must undergo and satisfy MRI safety screening
• Volunteers must be ≥ 16 years of age
• Participants must agree to registration as a non-patient in CWP (the Trust's Electronic Health Record - EHR- system) and have their MRIs read and reported for incidental findings by a clinical radiologist

Exclusion Criteria:

• Any contraindications to MRI identified after MRI safety screening including completion of an MRI Safety Screening Form
• Unable to tolerate MRI scan
• Known Pregnancy
• Known or suspected pathology in body region to be scanned
• Member of study team

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Developed and optimised of MRI scanning sequences for use in clinical radiotherapy practice in MR guided radiotherapy	on-going development of MRI protocols to be released for clinical use	Through study completion - up to 5 years

Collaborators and Investigators

• Sponsor: The Christie NHS Foundation Trust

Study record dates

Study Major Dates

• Study Start (Actual): August 1, 2021
• Primary Completion (Estimated): August 31, 2028
• Study Completion (Estimated): August 31, 2028

Study Registration Dates

• First Submitted: January 27, 2021
• First Submitted That Met QC Criteria: February 9, 2021
• First Posted (Actual): February 11, 2021

Study Record Updates

• Last Update Posted (Actual): August 24, 2025
• Last Update Submitted That Met QC Criteria: August 19, 2025
• Last Verified: August 1, 2025

More Information

Terms related to this study

• Other Study ID Numbers: CFTSp170

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No