Objective EEG Bed Side Assessment of Impaired Conscious Awareness in Epilepsy

Objective EEG Bed Side Assessment of Impaired Conscious Awareness in Epilepsy

Sponsors

Lead Sponsor: University Hospital Schleswig-Holstein

Collaborator: German Research Foundation

Source University Hospital Schleswig-Holstein
Brief Summary

In this project EEG recordings between healthy participants and those with a diagnosed Absence-epilepsy will be compared. The investigators suggest differences in EEG microstate analysis and neuropsychological parameters related to interictal cognitive impairment in these patients. This projects goal is to derive an EEG-based measure of conscious awareness.

Detailed Description

This projects goal is to derive an EEG-based measure of conscious awareness to be applied in the care for epilepsy patients. The established terminology of "ictal" versus "interictal" is deceptive because it suggests that during the "interictal" phase epileptic activity is absent and detrimental mechanisms of the disease are only active during seizures. But evidence exists that cognitive impairment extends to states traditionally considered interictal. The development of an objective, ideally ambulatory test assessing cognitive impairment would not only provide a deeper understanding of the pathology but induce a change in clinical practice: if cognitive impairment could be demonstrated "interictally", this fact would help to weigh treatment effects against potential side-effects. In this project the investigators will set out to 1. identify EEG markers in healthy volunteers, which reflect the changes in spatial and temporal dynamics of neuronal activity during states of reduced conscious awareness using sleep as an example of a state of reduced conscious awareness; 2. assess with neuropsychological testing reductions in interictal conscious awareness in patients with epilepsy; 3. test, whether markers established under (1) are valid in individuals with epilepsy and interictally reduced conscious awareness (see (2)).

Overall Status Not yet recruiting
Start Date 2021-06-01
Completion Date 2024-06-01
Primary Completion Date 2023-12-01
Study Type Observational
Primary Outcome
Measure Time Frame
temporal integration changes according to different sleep states 3 years
temporal integration changes in interictal EEG 3 years
graph modularity changes according to different sleep states 3 years
graph modularity changes in interictal EEG 3 years
Secondary Outcome
Measure Time Frame
EEG based measures (Outcome 4) correlate with 3 years
Enrollment 60
Condition
Eligibility

Sampling Method:

Non-Probability Sample

Criteria:

Inclusion Criteria: - age minimum 18 years - diagnosis of (absence) epilepsy // healthy age-matched controls - being of good health (besides epilepsy in the case group) Exclusion Criteria: - central nervous system disorders (besides epilepsy in the case group) - substance abuse - pregnancy

Gender:

All

Minimum Age:

18 Years

Maximum Age:

N/A

Healthy Volunteers:

Accepts Healthy Volunteers

Overall Official
Overall Contact

Last Name: Inken Toedt, Dr. phil. Dipl.-Psych.

Phone: 0049 431 500 23985

Email: [email protected]

Verification Date

2021-04-01

Responsible Party

Type: Principal Investigator

Investigator Affiliation: University Hospital Schleswig-Holstein

Investigator Full Name: Inken Toedt

Investigator Title: Scientist in Neuroimaging

Keywords
Has Expanded Access No
Condition Browse
Arm Group

Label: healthy subjects

Description: Age-matched healthy participants will be recruited via flyers at public education facilities and online advertisement. Participants need to be healthy and without central nervous system disorders and substance abuse. The investigators will also exclude pregnant women from the experiment.

Label: patients with absence epilepsy

Description: Apart from the diagnosis of epilepsy, patients need to be of good health and without central nervous system disorders and substance abuse. The investigators will also exclude pregnant women from the experiment.

Patient Data No
Study Design Info

Observational Model: Case-Control

Time Perspective: Prospective

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