Project RESIST: Increasing Resistance to Tobacco Marketing Among Young Adult Sexual Minority Women Using Inoculation Message Approaches (RESIST)

Project RESIST is an R01 study funded by NCI focused on determining the effects of using culturally tailored inoculation approaches to increase resilience to tobacco marketing influences among young adult sexual minority women ages 18-30 and incorporates critical stakeholder inputs that support later adoption and implementation. The study team is utilizing formative research to design and pre-test anti-smoking messages and two national longitudinal online survey experiments.

Study Overview

• Status: Completed
• Conditions: Cigarette Smoking Behavior
• Intervention / Treatment: Other: Culturally tailored anti-smoking messages; Other: Non-culturally tailored interventions

Detailed Description

This study will recruit 2000 young adult sexual minority women (SMW), ages 18-30 years, current smokers (n = 1000) and not current smokers (n=1000). The study team will randomly assign participants to a condition in which they will be exposed to either culturally tailored anti-smoking messages or non-tailored. Participants will receive these messages at baseline and 1, 2, and 3 weeks post baseline. They will be asked to complete a follow-up survey one month post baseline. Intentions to quit smoking as well as intention (among current smokers) and intention to purchase cigarettes (among current nonsmokers) will be measured at baseline and one-month post baseline.

• Study Type: Interventional
• Enrollment (Actual): 2214
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • California
    • Stanford, California, United States, 94305
      • Stanford University
  • Pennsylvania
    • Philadelphia, Pennsylvania, United States, 19104
      • University of Pennsylvania

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 30 years (Adult)
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Ages 18-30
• Woman
• Identifies as a sexual minority (any sexual orientation other than heterosexual)
• Lives in the United States
• Able to take surveys in English

Exclusion Criteria:

• Under 18 or older than 30
• Men
• Heterosexual
• Lives outside the United States
• Unable to take survey in English

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Culturally tailored (Non-smokers); The anti-smoking and anti-industry messages will be culturally tailored to specifically reach out to young adult SMW. They will receive only messages that are culturally tailored at baseline and weeks 1, 2, and 3. Culturally tailored anti-smoking messages: Anti-smoking messages that are culturally tailored for sexual minority women.	Other: Culturally tailored anti-smoking messages; Anti-smoking messages that are culturally tailored for sexual minority women.
Active Comparator: Non-culturally tailored (Non-smokers); The anti-smoking and anti-industry messages will not be culturally tailored. They will receive only messages that are not culturally tailored at baseline and weeks 1, 2 and 3. Non-culturally tailored interventions: Anti-smoking messages that are not culturally tailored for sexual minority women.	Other: Non-culturally tailored interventions; Anti-smoking messages that are not culturally tailored for sexual minority women.
Experimental: Culturally Tailored (Smokers); The anti-smoking and anti-industry messages will be culturally tailored to specifically reach out to young adult SMW. They will receive only messages that are culturally tailored at baseline and weeks 1, 2, and 3. Culturally tailored anti-smoking messages: Anti-smoking messages that are culturally tailored for sexual minority women.	Other: Culturally tailored anti-smoking messages; Anti-smoking messages that are culturally tailored for sexual minority women.
Active Comparator: Non-culturally Tailored (Smokers); The anti-smoking and anti-industry messages will not be culturally tailored. They will receive only messages that are not culturally tailored at baseline and weeks 1, 2 and 3. Non-culturally tailored interventions: Anti-smoking messages that are not culturally tailored for sexual minority women.	Other: Non-culturally tailored interventions; Anti-smoking messages that are not culturally tailored for sexual minority women.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Intention to Quit Smoking	Intention to quit smoking will be measured using the Burkhalter intention to quit smoking four item scale that measures readiness to cut down or quit smoking in the next 30 days at baseline and 1 month follow-up. Participants were asked to rate 4 statements: I will make an effort to quit smoking in the next 30 days (Unlikely to Likely); I intend to quit smoking in the next 30 days (Strongly disagree to Strongly Agree); I expect to quit smoking in the next 30 days (Definitely false to Definitely true); How likely is it that you will quit smoking in the next 30 days (Unlikely to Likely). Responses ranged on 7-point Likert-like scales. Responses were summed to create a scale for intention to quit (range from 4-28). This will only be measured among current smokers. Lowest score is 4 and highest mean score is 28. Higher scores indicate increased intention to quit smoking within the next 30 days.	Day 30
Change in Intention to Purchase Cigarettes	The Juster scale was used to measure intention to purchase cigarettes at baseline and at one-month follow-up. Participants were asked, "How likely are you to purchase cigarettes in the next 6 months?" Responses ranged from 0=No chance, almost no chance (1 in 100) to 10=Certain, practically certain (99 in 100). Higher values reflect higher intention to purchase.	Day 30

Collaborators and Investigators

• Sponsor: Abramson Cancer Center at Penn Medicine
• Collaborators: National Cancer Institute (NCI); Dana-Farber Cancer Institute; Stanford University; Michigan State University; Harvard School of Public Health (HSPH); Fenway Community Health

Study record dates

Study Major Dates

• Study Start (Actual): September 8, 2021
• Primary Completion (Actual): May 5, 2022
• Study Completion (Actual): June 20, 2022

Study Registration Dates

• First Submitted: March 9, 2021
• First Submitted That Met QC Criteria: March 20, 2021
• First Posted (Actual): March 24, 2021

Study Record Updates

• Last Update Posted (Actual): November 15, 2023
• Last Update Submitted That Met QC Criteria: November 13, 2023
• Last Verified: November 1, 2023

More Information

Terms related to this study

• Other Study ID Numbers: 843579; R01CA237670 (U.S. NIH Grant/Contract)

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No