- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04820049
F573 Ia Clinical Trial
November 7, 2022 updated by: Beijing Continent Pharmaceutical Co, Ltd.
F573 for Injection Phase Ia Clinical Trial.
Tolerance and PK study of F573
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
The tolerance and PK study of single dose and multi dose F573.
Study Type
Interventional
Enrollment (Actual)
100
Phase
- Phase 1
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Hubei
-
Wuhan, Hubei, China, 430022
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 45 years (Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion criteria (each item must be met)
- Healthy volunteers, male and female;
- Age: 18-45 years old;
- Weight: male ≥50kg, female ≥45kg, 19≤BMI≤26 (BMI= weight (kg)/height 2 (m2));
- Passed the comprehensive physical examination, that is, the routine blood and urine, blood pregnancy, blood glucose, blood lipids, blood electrolytes, hepatitis B surface antigen, liver and kidney function, hepatitis C, HIV and syphilis antibody test, electrocardiogram, cigarette test, urine drug screening, alcohol breath test, chest X-ray and other abnormal or abnormal without clinical significance;
- Have a detailed understanding of the nature, significance, possible benefits, possible inconveniences and potential risks of the trial before the study, and voluntarily participate in the clinical trial, be able to communicate well with the researchers, comply with the requirements of the whole study, and have the ability to understand and sign the written informed consent.
Exclusion criteria (if one of them is met)
- Participated in any other clinical trials within the three months prior to the trial;
- (preliminary) of any process may affect test security, or drug in the body of the disease, including but not limited to: heart, liver, kidney, endocrine, the digestive tract, immune system and respiratory system always or the existing system diseases (especially cardiovascular diseases including cardiovascular disease risk, any impact on drug absorption of gastrointestinal diseases (such as irritable bowel syndrome, inflammatory bowel disease), active pathological bleeding (such as peptic ulcer), urticaria, eczema, dermatitis, epilepsy, allergic rhinitis, asthma, etc.);
- (Inquiry) Allergic constitution: if there is a history of drug, food allergy or skin allergy;
- (Inquiry) Use of any drug that inhibits or induces liver metabolism to the drug within 28 days prior to use of the study drug (Common liver enzyme inducers: barbiturates such as phenobarbital, carbamazepine, aminomide, griseofulvin, metalpropanol, phenytoin, glumide, rifampicin, dexamethasone; Common liver enzyme inhibitors: chlorpromazine, cimetidine, ciprofloxacin, metronidazole, chloramphenicol, isoniazid, sulfonamides);
- Have used any medicine (including Chinese herbal medicine) and health care products within 14 days before the first administration;
- (Consultation) People who have special requirements for food and cannot abide by the unified diet (such as intolerance to standard food);
- (consultation) can not tolerate venipuncture, intramuscular injection and/or have a history of dizziness of blood and needles;
- (Consultation) Drinking excessively tea, coffee or caffeinated beverages for a long time in the past (more than 8 cups a day, 1 cup =250mL); Or study within 48 hours before the first administration of the drug, the intake of any food or beverage containing caffeine (such as coffee, strong tea, chocolate, etc.) and other special diet that affects the absorption, distribution, metabolism, excretion of the drug;
- (Inquiry) Previous alcohol abuse (i.e., more than 28 SUs per week for men and more than 21 SUs per week for women (1 SU contains 14 g of alcohol, such as 360 mL beer or 45 mL 40% spirits or 150 mL wine); Or regular alcohol consumption (more than 14 standard units per week) in the 6 months prior to the study; Or have taken any alcoholic product within 24 hours prior to first administration;
- (Inquiry) who donated blood or suffered massive bleeding (greater than 450 mL) within 3 months before the first administration of the study, or who planned to donate blood or blood components during the study or within 3 months after the end of the study;
- (Inquiry) Acute disease occurs in the pre-study screening stage or before the study medication;
- (Inquiry) Those who took food or beverage (such as grapefruit, mango, dragon fruit, grape juice, orange juice and other rich flavonoids or citrus compounds) containing enzymes that can induce or inhibit liver metabolism within 24 hours before the first administration of medication;
- (Consultation) had surgery within 3 months prior to the screening period, or planned to have surgery during the study period;
- (Inquiry) Previous history of drug abuse; With a history of drug abuse;
- Smoking more than 5 cigarettes per day in the 14 days before screening, or unable to stop using any tobacco products during the trial;
- Screening (Consultation) Those who smoked or used any tobacco products during the admission period;
- Positive results of nicotine test;
- Alcohol breath test with test results greater than 0.0mg/100mL;
- Positive urine drug screening;
- Pregnant or lactating women;
- Those who had family planning during the study period and within 6 months after the end of the study;
- Refusing to use non-drug contraception during the study period
- novel coronavirus nucleic acid test positive or antibody test positive;
- The investigator considers that there is any circumstance that may affect the subject's ability to give informed consent or follow the study protocol, or that the participant's participation in the study may affect the study result or their own safety.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Other
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Placebo Comparator: Placebo group
|
Water for injection
|
Experimental: F573 group
|
F573 for injection
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
MTD of F573 in health people
Time Frame: up to 7 days
|
up to 7 days
|
Cmax of F573 in health people
Time Frame: up to 7 days
|
up to 7 days
|
Tmax of F573 in health people
Time Frame: up to 7 days
|
up to 7 days
|
t1/2 of F573 in health people
Time Frame: up to 7 days
|
up to 7 days
|
AUC of F573 in health people
Time Frame: up to 7 days
|
up to 7 days
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Number of participants with treatment-related adverse events as assessed by CTCAE v5.0
Time Frame: 8 days
|
8 days
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
February 8, 2021
Primary Completion (Actual)
August 2, 2022
Study Completion (Actual)
November 6, 2022
Study Registration Dates
First Submitted
February 3, 2021
First Submitted That Met QC Criteria
March 25, 2021
First Posted (Actual)
March 29, 2021
Study Record Updates
Last Update Posted (Actual)
November 8, 2022
Last Update Submitted That Met QC Criteria
November 7, 2022
Last Verified
March 1, 2021
More Information
Terms related to this study
Other Study ID Numbers
- GNI-F573-202001
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
No
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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