Effects of Resistance Exercise on Metabolic Responses

Effects of Volume-matched Resistance Exercise With Different Loads on Metabolic Responses

Healthy young adults will complete three trials in a randomized crossover counter-balanced order, including two different loads of resistance exercise and sedentary control. During each trial, blood samples will be collected.

The investigators hypothesized that high-load and low-load resistance exercise exert similar metabolic responses.

Study Overview

• Status: Completed
• Conditions: Inflammatory Response
• Intervention / Treatment: Other: High-load resistance exercise; Other: Low-load resistance exercise

• Study Type: Interventional
• Enrollment (Actual): 11
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Taiwan
  • Taipei, Taiwan, 162
    • National Taiwan Normal University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 30 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• Age: 20-30
• Healthy male
• Without experience of resistance training

Exclusion Criteria:

• No acute or chronic musculoskeletal symptoms
• Smoking
• Alcohol or drug abuse
• Fail to conduct resistance exercise

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: High-load resistance exercise; 4 high-load resistance exercises that target all major muscle groups.	Other: High-load resistance exercise; Subjects in high-load trial performed 4 sets per exercise, 8 repetitions with load of 85%-8RM with 90 sec of rest between sets.
Experimental: Low-load resistance exercise; 4 low-load resistance exercises that target all major muscle groups.	Other: Low-load resistance exercise; Subjects in low-load trial performed 4 sets per exercise, 15 repetitions with load of 45%-8RM with 90 sec of rest between sets.
No Intervention: Sedentary control; Subjects in control trial stayed sedentary during the period.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Changes in glucose	glucose in mg/dL	4-hour during each study intervention
Changes in insulin	insulin in mU/L	4-hour during each study intervention
Changes in TG	TG mg/dL	4-hour during each study intervention
Changes in uric acid	uric acid mg/dL.	4-hour during each study intervention

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Changes in biomarkers of inflammation	Biomarkers of inflammation will be measured such as IL-10 in pg/mL and IL-6 in pg/mL.	4-hour during each study intervention
Changes in cortisol	cortisol in ng/mL	4-hour during each study intervention
Changes in lactate	lactate in mmol/L	4-hour during each study intervention
Changes in complete blood count	blood cell count in count per µL	4-hour during each study intervention
Borgs Ratings of Perceived Exertion (RPE)	Borgs RPE is a method of estimating exertion rating, based on a 6 to 20 rating scale (6 being the no exertion at all, 20 being maximal exertion).	1-hour during each exercise intervention
Changes in ET-1	ET-1 in pg/mL	4-hour during each study intervention
Changes in NO	NO in µmol/L	4-hour during each study intervention
Changes in biomarkers of muscle damage	Biomarkers of muscle damage will be measured such as CK in U/L and LDH in U/L.	4-hour during each study intervention
Heart rate (HR)	HR will be measured during each study intervention.	6-hour during each study intervention
Visual Analogue Scale (VAS) of appetite	Hunger, fullness, desire to eat, and prospective food consumption will be measured via VAS ratings, based on a 100 mm long scale (0 being "not at all", 100 being "extremely").	6-hour during each study intervention
Changes in biomarkers of appetite	Biomarkers of appetite will be measured such as ghrelin in pg/mL and PYY in pg/mL.	4-hour during each study intervention

Collaborators and Investigators

• Sponsor: National Taiwan Normal University
• Investigators: Principal Investigator: Hung-wen Liu, Ph.D., National Taiwan Normal University

Study record dates

Study Major Dates

• Study Start (Actual): February 18, 2021
• Primary Completion (Actual): March 7, 2021
• Study Completion (Actual): December 31, 2021

Study Registration Dates

• First Submitted: August 30, 2021
• First Submitted That Met QC Criteria: September 10, 2021
• First Posted (Actual): September 21, 2021

Study Record Updates

• Last Update Posted (Actual): March 16, 2022
• Last Update Submitted That Met QC Criteria: March 14, 2022
• Last Verified: March 1, 2022

More Information

Terms related to this study

• Keywords: resistance exercise; immune response; equal training volume
• Other Study ID Numbers: 202011HM005

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No