Resistance Exercise Training at Different Intensities

Resistance Exercise Training at Different Intensities in Healthy and Frail Older People: A Feasibility Study

The aim of the current study, therefore, is to determine the feasibility of recruitment and adherence to resistance exercise training interventions performed at low and high loads, to volitional muscular failure, in a trial population that includes both healthy and frail older people.

Study Overview

• Status: Completed
• Conditions: Frailty; Sarcopenia; Aging
• Intervention / Treatment: Behavioral: Low Load Resistance exercise; Behavioral: High Load Resistance exercise

• Study Type: Interventional
• Enrollment (Actual): 60
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United Kingdom
  • Glasgow, United Kingdom, G12 8TA
    • GRI Clinical Research Facility

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 65 years and older (Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Over age of 65 years

Exclusion Criteria:

• Current participation in an exercise programme
• Exercise deemed unsafe by clinical team

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Low load; Training at 30-40% one-repetition maximum (1RM)	Behavioral: Low Load Resistance exercise; leg extension, leg press, leg curl and calf press
Experimental: High load; Training at 65-75% one-repetition maximum (1RM)	Behavioral: High Load Resistance exercise; leg extension, leg press, leg curl and calf press

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Muscle strength	Knee extensor maximal torque during an isometric MVC	Change from baseline to 8 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Vastus lateralis muscle thickness	Measured via ultrasound	Change from baseline to 8 weeks
Muscle strength	Knee flexor maximal torque during an isometric MVC	Change from baseline to 8 weeks
One-repetition maximum	leg extension, leg curl, leg press and calf press	Change from baseline to 8 weeks
Biomechanics during walking and stair climbing	Motion analysis	Change from baseline to 8 weeks
Short performance physical battery test	SPPB - balance, walking pace and chair rise	Change from baseline to 8 weeks
Quality of life measure	EQ-5D-5L questionnaire	Change from baseline to 8 weeks

Collaborators and Investigators

• Sponsor: University of Glasgow
• Investigators: Principal Investigator: Stuart Gray, University of Glasgow

Study record dates

Study Major Dates

• Study Start (Actual): March 1, 2018
• Primary Completion (Actual): December 18, 2019
• Study Completion (Actual): December 18, 2019

Study Registration Dates

• First Submitted: August 9, 2019
• First Submitted That Met QC Criteria: August 9, 2019
• First Posted (Actual): August 13, 2019

Study Record Updates

• Last Update Posted (Actual): March 25, 2020
• Last Update Submitted That Met QC Criteria: March 24, 2020
• Last Verified: March 1, 2020

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Nervous System Diseases; Neurologic Manifestations; Neuromuscular Manifestations; Pathological Conditions, Anatomical; Muscular Atrophy; Atrophy; Frailty; Sarcopenia
• Other Study ID Numbers: 236559

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No