Intake Duration Effects of Blackcurrant on Cardiovascular and Metabolic Responses

Effects of Intake Duration of New Zealand Blackcurrant Extract on Physiological, Cardiovascular and Metabolic Responses at Rest and During Moderate-intensity Exercise in Healthy Males

Study will examine the metabolic, physiological and cardiovascular changes by intake of New Zealand blackcurrant extract at rest and during moderate-intensity treadmill walking in healthy males.

Study Overview

• Status: Completed
• Conditions: no Conditions
• Intervention / Treatment: Dietary supplement: New Zealand blackcurrant extract

Detailed Description

The investigators will examine effects of acute intake, intermittent intake and chronic intake of New Zealand blackcurrant extract using indirect calorimetry and hemodynamic measurements.

• Study Type: Interventional
• Enrollment (Actual): 15
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United Kingdom
  • West Sussex
    • Chichester, West Sussex, United Kingdom, PO19 6PE
      • Mark Willems

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 45 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• Healthy
• Non-smokers
• Not taking any supplements
• No known allergy to berries or berry products

Exclusion Criteria

• Sedentary
• Known high blood pressure
• Smoking
• On medication

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: new zealand blackcurrant extract; Capsules will be take daily or every other day.	Dietary supplement: New Zealand blackcurrant extract; Capsules taken daily or intermittent
Placebo Comparator: control; no capsules will be provided.	Dietary supplement: New Zealand blackcurrant extract; Capsules taken daily or intermittent

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Changes in heart rate from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract	The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise. Heart rate will be measured in beats/min.	baseline, acute, one week and two weeks
Changes in stroke volume from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract	The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise. Stroke volume will be measured in mL.	baseline, acute, one week and two weeks
Changes in cardiac output from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract	The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise. Cardiac output will be measured in L/min.	baseline, acute, one week and two weeks
Changes in blood pressure from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract	The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise. Systolic, diastolic and mean arterial blood pressure will be measured in mmHg.	baseline, acute, one week and two weeks
Changes in total peripheral resistance from baseline with acute intake, one week and two weeks intake of New Zealand blackcurrant extract	The investigators will use a beat-to-beat blood pressure monitoring system (Portapres® Model 2, Finapres Medical Systems BV, Amsterdam, The Netherlands). The Portapres® is a beat-to-beat finger pressure analyser that allows the non-invasive continuous measurement of hemodynamic parameters. The finger cuff will be positioned around the same finger of the left hand for each testing. All measurements will be taken in rest and during moderate-intensity exercise. Total peripheral resistance will be measured in (mmHg·min)/L	baseline, acute, one week and two weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Changes in oxygen consumption from baseline with acute intake, one week and two weeks intake.	The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking. Oxygen consumption will be measured in L/min	baseline, acute, one week and two weeks
Changes in carbon dioxide production from baseline with acute intake, one week and two weeks intake.	The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking. Carbon dioxide production will be measured in L/min.	baseline, acute, one week and two weeks
Changes in respiratory exchange ratio from baseline with acute intake, one week and two weeks intake.	The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking. Respiratory exchange ratio is unitless and calculated from the ratio of carbon dioxide production and oxygen consumption.	baseline, acute, one week and two weeks
Changes in carbohydrate oxidation from baseline with acute intake, one week and two weeks intake.	The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking. Carbohydrate oxidation is calculated using carbon dioxide production and oxygen consumption and expressed in g/min.	baseline, acute, one week and two weeks
Changes in fat oxidation from baseline with acute intake, one week and two weeks intake.	The investigators will use Douglas bags to collect expired air. Indirect calorimetry techniques will be used to measured oxygen consumption and carbon dioxide production and allow quantification of carbohydrate and fat oxidation in rest and during moderate-intensity treadmill walking. Fat oxidation is calculated using carbon dioxide production and oxygen consumption and expressed in g/min.	baseline, acute, one week and two weeks

Collaborators and Investigators

• Sponsor: University of Chichester
• Investigators: Principal Investigator: Mark E Willems, PhD, University of Chichester

Publications and helpful links

General Publications

• Sahin PhD MA, Bilgic PhD P, Montanari MSc S, Willems PhD MET. Intake Duration of Anthocyanin-Rich New Zealand Blackcurrant Extract Affects Metabolic Responses during Moderate Intensity Walking Exercise in Adult Males. J Diet Suppl. 2021;18(4):406-417. doi: 10.1080/19390211.2020.1783421. Epub 2020 Jun 24.
• Sahin PhD MA, Bilgic PhD P, Montanari MSc S, Willems PhD MET. Daily and Not Every-Other-Day Intake of Anthocyanin-Rich New Zealand Blackcurrant Extract Alters Substrate Oxidation during Moderate-Intensity Walking in Adult Males. J Diet Suppl. 2022;19(1):49-61. doi: 10.1080/19390211.2020.1841356. Epub 2020 Oct 29.

Study record dates

Study Major Dates

• Study Start (Actual): September 1, 2017
• Primary Completion (Actual): September 1, 2018
• Study Completion (Actual): September 1, 2018

Study Registration Dates

• First Submitted: September 10, 2021
• First Submitted That Met QC Criteria: October 1, 2021
• First Posted (Actual): October 4, 2021

Study Record Updates

• Last Update Posted (Actual): October 4, 2021
• Last Update Submitted That Met QC Criteria: October 1, 2021
• Last Verified: October 1, 2021

More Information

Terms related to this study

• Other Study ID Numbers: MW1718NZBCduration

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: But will be provide on request.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No