Comparing the Effects of Exercise on the Structure and Function of Fat Tissue (CAT)

Effects of Exercise Training on the Structure and Metabolic Function of Fat Tissue

Assess differences in structure and biological function of abdominal subcutaneous adipose tissue samples collected from adults who exercise regularly vs. a well-matched cohort of non-exercisers.

Study Overview

• Status: Completed
• Conditions: Adiposity
• Intervention / Treatment: Diagnostic test: Oral Glucose Tolerance Test

• Study Type: Interventional
• Enrollment (Actual): 45
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Michigan
    • Ann Arbor, Michigan, United States, 48109
      • University of Michigan

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 40 years (Adult)
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Age: 18-40 years old
• Body Mass Index: 23-35 kg/m2
• Women must have regularly occurring menses and must be premenopausal

Exclusion Criteria:

• Evidence/history of cardiovascular or metabolic disease
• Medications known to affect lipid or glucose metabolism, or inflammation
• Weight instability ≥ ± 6 pounds in the last 6 months
• Tobacco or e-cigarette users
• Women must not be pregnant or actively lactating
• Blood pressure > 140/90 mmHg

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Oral Glucose Tolerance Test; Subjects will complete an Oral Glucose Tolerance Test in which glucose is given and blood samples are taken every 15 minutes over a 2 hour period to determine how quickly the glucose is cleared from the blood.	Diagnostic test: Oral Glucose Tolerance Test; Subjects will complete an Oral Glucose Tolerance Test in which glucose is given and blood samples are taken every 15 minutes over a 2 hour period to determine how quickly the glucose is cleared from the blood.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Blood Glucose Level	mg/dL	2 hours at Experimental Trial
Adipose tissue fibrosis	Pico-sirius Red stain (percent stained)	baseline

Collaborators and Investigators

• Sponsor: University of Michigan
• Investigators: Principal Investigator: Jeffrey F Horowitz, PhD, University of Michigan

Study record dates

Study Major Dates

• Study Start (Actual): June 4, 2020
• Primary Completion (Actual): August 3, 2023
• Study Completion (Actual): December 9, 2024

Study Registration Dates

• First Submitted: April 7, 2022
• First Submitted That Met QC Criteria: April 7, 2022
• First Posted (Actual): April 14, 2022

Study Record Updates

• Last Update Posted (Actual): June 29, 2025
• Last Update Submitted That Met QC Criteria: June 25, 2025
• Last Verified: June 1, 2025

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Nutrition Disorders; Overnutrition; Body Weight; Overweight; Obesity
• Other Study ID Numbers: HUM00179332

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No