- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05393739
Effect of Transcranial Magnetic Stimulation on Visual Functions of Adult Amblyopia: a Preliminary Study
Amblyopia, with a prevalence rates of 3% in adult population, is a common cause of vision impairment. It is characterized by impaired vision in one or both eyes because of disruption of normal visual stimuli and underdevelopment of the visual cortex, leads to lifelong visual deficits affecting both monocular and binocular visual function. Common causes of amblyopia include refraction error, anisometropia, strabismus and visual deprivation arising from ptosis or congenital cataract. Our previous studies had shed light on the relationship between abnormal early visual experience, and development of later amblyopia and possible neural developmental disorders. Functional recovery is difficult when neuroplasticity slows down at the end of the critical period. To date, there is no established effective treatment for adult amblyopia.
Repetitive transcranial magnetic stimulation (rTMS) is one of the non-invasive stimulations had been used widely as a research tool to understand the brain functions and an established treatment modality in neuropsychiatric diseases. Theta burst stimulation (TBS) is a newer form of rTMS protocol which have a major advantage over traditional rTMS in their reduced administration duration and allowing stimulation at significantly lower intensities to attain comparable effects. TBS had been demonstrated to able to improve functions in participants with visual disorders. However, studies of its use on adult amblyopia are scarce. Due to lack of efficient treatment at present, it is of scientific significance to conduct placebo-controlled experiments on this topic. Investigators will evaluate the effect of three regimens of TBS (intermittent, continuous and sham), after one session and accumulative sessions, on visual functions of amblyopia adults shortly after treatment and 2 weeks later (lasting effect), in order to evaluate its potential role in amblyopia and find out the best paradigm for amblyopia treatment.
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Tzu-Hsun Tsai, PhD
- Phone Number: 65906 886223123456
- Email: lucia_tsai@yahoo.com.tw
Study Locations
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Taipei county, Taiwan, 100225
- Recruiting
- National Taiwan University Hospital
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Contact:
- Tzu-Hsun Tsai, PhD
- Phone Number: 65906 886223123456
- Email: lucia_tsai@yahoo.com.tw
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Adult amblyopia participants, aged 20-50 years old.
- Based on inclusion criteria, there was a minimum of 2 lines difference in BCVA between the 2 eyes.
- An amblyogenic factor and history of amblyopia treatment was recorded
Exclusion Criteria:
- Unstable vital sign
- History of brain injury and/or head trauma
- Neurological and psychiatric disease
- Seizures or family history of seizure
- Pregnancy
- Uncontrolled migraine or the presence of metallic implants or shunt in the head or torso
- Wide region of ischemic cicatrix, multiple sclerosis, taking tricycle antidepressants,
- Analgesics or any drugs may decrease the threshold for inducing seizure
- Experienced sleep disorders during the rTMS treatment
- Severe alcoholism or taking seizure drugs
- Severe heart diseases or uncontrollable migraine caused by high intracranial pressure
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Health Services Research
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Intermittent theta burst
The total TBS time is about 1 to 3 minutes and the subjects have to look at at a visual stimulus on a computer monitor while receiving TBS and continue the visual training until 20 minutes after the treatment.
In iTBS group, the subjects look at the visual stimulus with amblyopic eye while in cTBS group, subjects look at visual stimulus with non-amblyopic eye.
The subjects will receive three times of stimulations in one week.
The visual function evaluation includes BCVA, contrast sensitivity and stereoacuity.
Visual functions will be evaluated right after TBS session (t1).
Participant will receive same type of treatment for another 2 times within one week followed by visual function tests (t2).
To evaluate the long-term effect, participants will be followed for another visual function tests (t3) after 2 weeks.
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The procedure includes determining the specific occipital point at which place the stimulation coil; this corresponds to the area where magnetic stimulation is most capable of inducing phosphenes or transient visual phenomena.
The phosphenes are directly induced by stimulation of the visual cortex and their presence indicates that the magnetic stimulation is in the correct location.
The subjects would wear a personalized swimming cap with the determined area for stimulation marked on it.
The major differences between iTBS and cTBS are the frequency and interval of stimulus.
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Experimental: Continuous theta burst
The total TBS time is about 1 to 3 minutes and the subjects have to look at at a visual stimulus on a computer monitor while receiving TBS and continue the visual training until 20 minutes after the treatment.
In iTBS group, the subjects look at the visual stimulus with amblyopic eye while in cTBS group, subjects look at visual stimulus with non-amblyopic eye.
The subjects will receive three times of stimulations in one week.
The visual function evaluation includes BCVA, contrast sensitivity and stereoacuity.
Visual functions will be evaluated right after TBS session (t1).
Participant will receive same type of treatment for another 2 times within one week followed by visual function tests (t2).
To evaluate the long-term effect, participants will be followed for another visual function tests (t3) after 2 weeks.
|
The procedure includes determining the specific occipital point at which place the stimulation coil; this corresponds to the area where magnetic stimulation is most capable of inducing phosphenes or transient visual phenomena.
The phosphenes are directly induced by stimulation of the visual cortex and their presence indicates that the magnetic stimulation is in the correct location.
The subjects would wear a personalized swimming cap with the determined area for stimulation marked on it.
The major differences between iTBS and cTBS are the frequency and interval of stimulus.
|
Sham Comparator: Sham theta burst
The stimulus intensity in sham group is about half of that in iTBS/cTBS groups, and the subjects receive a placebo stimulation with the coil orientation tilted to 90°.
The visual function evaluation includes BCVA, contrast sensitivity and stereoacuity.
Visual functions will be evaluated right after TBS session (t1).
Participant will receive same type of treatment for another 2 times within one week followed by visual function tests (t2).
To evaluate the long-term effect, participants will be followed for another visual function tests (t3) after 2 weeks.
|
The procedure includes determining the specific occipital point at which place the stimulation coil; this corresponds to the area where magnetic stimulation is most capable of inducing phosphenes or transient visual phenomena.
The phosphenes are directly induced by stimulation of the visual cortex and their presence indicates that the magnetic stimulation is in the correct location.
The subjects would wear a personalized swimming cap with the determined area for stimulation marked on it.
The major differences between iTBS and cTBS are the frequency and interval of stimulus.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Objective
Time Frame: 1 month for each participant
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Change from baseline best corrected visual acuity: distance visual acuity measured for each eye at a distance of 6 m.
Visual acuity scored letter-by-letter instead and lonarithm of the minimum angle of resolution (logMAR) scores were recored.
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1 month for each participant
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Collaborators and Investigators
Investigators
- Principal Investigator: Tzu-Hsun Tsai, National Taiwan University Hospital
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 202106139DINC
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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