The Effect of Hypercapnia on Physiological Parameters During Short-term Breathing (HYPERCO)

March 10, 2026 updated by: Czech Technical University in Prague

The Effect of Hypercapnia and Hypoxia on Physiological Parameters During Short-term Breathing Experiment

The aim of the project is to evaluate the effect of hypercapnia on physiological parameters in a healthy person during short-term hypoxia and hypercapnia.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Hypercapnia causes changes in physiological parameters at various levels throughout the body. The study aims to evaluate the effect of hypercapnia on physiological parameters in a healthy person during short-term hypoxia and hypercapnia. It is an intervention prospective study that will be conducted at the Faculty of Biomedical Engineering on healthy volunteers. All the volunteers undergo three different phases in random order. The individual phases differ in the breathed mixture of oxygen, nitrogen and carbon dioxide gases. Non-invasive measurements of physiological parameters, especially blood oxygen saturation, perfusion index and cardiac output, will be performed continuously during the experiment.

Study Type

Interventional

Enrollment (Actual)

15

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Czechia
      • Kladno, Czechia, 27201
        • Czech Technical University in Prague

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 40 years (Adult)

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Healthy volunteers

Exclusion Criteria:

  • pregnancy
  • severe cardiovascular conditions
  • severe asthma or other severe respiratory conditions
  • injury to the upper limbs or hands that could affect the peripheral perfusion
  • diabetes
  • hypotension or hypertension

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Hypoxic
Participants inhale ambient air, the hypoxic gas mixture, and ambient air.
Other: Hypoxic
Hypoxic gas mixture Gas mixture of 10% O2 and 90% N2 for six minutes.
Experimental: Hypercapnic
Participants inhale ambient air, the hypercapnic gas mixture, and ambient air.
Other: Hypercapnic
Hypercapnic gas mixture Gas mixture of 21% O2, 5% CO2 74% N2 for six minutes.
Experimental: Hypoxic and Hypercapnic
Participants inhale ambient air, the hypoxic and hypercapnic gas mixture, and ambient air.
Other: Hypoxic and Hypercapnic
Hypoxic and Hypercapnic gas mixture Gas mixture of 10% O2, 5% CO2 85% N2 for six minutes.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Changes in Cardiac output due to the induced hypoxia and hypercapnia
Time Frame: 1 hour
Based on the induced hypoxia, hypercapnia or combination of hypoxia and hypercapnia, Cardiac output will change
1 hour
Changes in Perfusion index due to the induced hypoxia and hypercapnia
Time Frame: 1 hour
Based on the induced hypoxia, hypercapnia or combination of hypoxia and hypercapnia, Perfusion index will change
1 hour

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Czech Technical University in Prague

Investigators

  • Principal Investigator: Karel Roubik, Professor, Czech Technical University in Prague

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

June 22, 2022

Primary Completion (Actual)

March 30, 2024

Study Completion (Actual)

June 30, 2024

Study Registration Dates

First Submitted

June 25, 2022

First Submitted That Met QC Criteria

June 29, 2022

First Posted (Actual)

July 1, 2022

Study Record Updates

Last Update Posted (Actual)

March 11, 2026

Last Update Submitted That Met QC Criteria

March 10, 2026

Last Verified

March 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CTU HYPERCO

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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