Vital Pulp Therapy With Different Materials for Young Permanent Teeth

September 27, 2025 updated by: Nada mohamed, Mansoura University

Clinical Evaluation of Different Treatment Modalities for Vital Pulp of Immature Permanent Molars

This study will be conducted to:

Evaluate clinically and radiographically apexogenesis in immature permanent molars using:

  1. Calcium Hydroxide.
  2. MTA.
  3. Laser.
  4. Laser combined with MTA.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Calcium Hydroxide has been the most commonly utilized pulpotomy agent for vital pulp therapy. It is the earliest medicament employed in pulpotomy that possesses the ability to stimulate tertiary dentinogenesis. This is attributed to its high alkalinity after mixing with water. Calcium hydroxide has a high pH, and its dental use relates chiefly to its ability to stimulate mineralization and also to its antibacterial property.

Biocompatibility and sealing ability are the most important properties, which account for optimal healing response in vital pulp therapy. Unlike conventional materials, MTA has low solubility and maintains its physical integrity after placement. It has several desirable characteristics in terms of biocompatibility, bioactivity, hydrophilicity, radiopacity, sealing ability and low solubility.

Diode laser in a young permanent tooth with traumatically exposed pulp has proved to be an effective technique for Pulpotomy in an immature tooth. Therefore, the use of soft-tissue diode lasers can influence the treatment outcome and should be seen as a predicable tool for vital pulp therapy.

Study Type

Interventional

Enrollment (Actual)

100

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
    • Dakhalia Governrate
      • Al Mansurah, Dakhalia Governrate, Egypt, 35516
        • Mansoura University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

3 years to 5 years (Child)

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Medically free
  • Vital teeth

Exclusion Criteria:

  • Medically compromised
  • Chronic abscess
  • Non-vital teeth

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Other: Examiner
Other: calcium hydroxide
Dental pulp medicament material
Other: MTA
Dental pulp medicament material
Device: Diode Laser
Device used in pulp therapy
No Intervention: Patient

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Root completion
Time Frame: one year
Closure of radiographic apex using Scanora 5.2.6 digital software
one year

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Root lengthening and thickening
Time Frame: one year
Measuring the increase in length and width of the root canals using Scanora 5.2.6 digital software
one year

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
Clinical evaluation
Time Frame: one year
Absence of pain and tenderness to percussion using facial scale
one year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Mansoura University

Investigators

  • Study Director: Salwa M Awad, Professor, Mansoura University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 1, 2022

Primary Completion (Actual)

September 30, 2023

Study Completion (Actual)

April 1, 2024

Study Registration Dates

First Submitted

August 10, 2022

First Submitted That Met QC Criteria

August 10, 2022

First Posted (Actual)

August 12, 2022

Study Record Updates

Last Update Posted (Estimated)

October 2, 2025

Last Update Submitted That Met QC Criteria

September 27, 2025

Last Verified

September 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Vital pulp therapy

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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