Post-operative Pain Reduction

April 6, 2020 updated by: Mohamed Salah Mohamed Fahmy, Minia University

Post-operative Pain Reduction After Application of Three Intracanal Medicament Within Necrotic Root Canals and Pulp

Recruited patients with necrotic pulp after application of conventional calcium hydroxide paste are assigned to group, Calcium hydroxide nanoparticle group and Combined Calcium hydroxide with silver nanoparticle group and record postoperative pain afterwards.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Detailed Description

The investigator will recruit patients who are found eligible to the criteria, conventional calcium hydroxide paste , Calcium hydroxide nanoparticle and Combined Calcium hydroxide with silver nanoparticle . After 48 hours, patients will be randomly assigned to removal of intracanal medication

After the visit, patients will be asked to record post operative pain by Numerical Rating Scale)in a given sheet

Study Type

Interventional

Enrollment (Anticipated)

30

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
      • Minya, Egypt
        • Recruiting
        • Faculty of Dentistry, Minia University
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

23 years to 48 years (Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • • Medically free patients.

    • Patient's age between 25-50 years.
    • Sex includes both male and female.
    • Radiographic evidence of a periapical radiolucent lesion associated with tooth.
    • Necrotic pulp as indicated by thermal pulp testing.
    • No history of previous endodontic treatment of the tooth.

Exclusion Criteria:

  • • Teeth with unfavorable conditions for rubber-dam application.

    • Teeth with acute periapical abscesses swelling.
    • Medically compromised patients.
    • Immature teeth with open apices.
    • Multi rooted teeth.
    • Pregnant women.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Conventional calcium hydroxide paste
Application of Conventional calcium hydroxide paste
Drug: Conventional calcium hydroxide paste
Conventional calcium hydroxide paste (Ultracal) will be removed in second visit.
Other Names:
  • Ultracal
Experimental: Calcium hydroxide nanoparticle
Application of Calcium hydroxide nanoparticle
Drug: Calcium hydroxide nanoparticle
Calcium hydroxide nanoparticle. manufactured in NanoTech. institute, will be removed in second visit.
Experimental: Combined Calcium hydroxide with silver nanoparticle
Application of Combined Calcium hydroxide with silver nanoparticle
Drug: Combined Calcium hydroxide with silver nanoparticle
Combined Calcium hydroxide with silver nanoparticle will be removed in second visit.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
change in post operative pain (Visual Analogue Scale)
Time Frame: Intrappointment at 4,24,48,72 and 96 hours ]
Numerical (0-10)
Intrappointment at 4,24,48,72 and 96 hours ]

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Minia University

Investigators

  • Study Director: Magdy Mohamed Aly, Professor, Dean of Faculty

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Anticipated)

April 1, 2020

Primary Completion (Anticipated)

November 1, 2020

Study Completion (Anticipated)

November 1, 2020

Study Registration Dates

First Submitted

April 6, 2020

First Submitted That Met QC Criteria

April 6, 2020

First Posted (Actual)

April 8, 2020

Study Record Updates

Last Update Posted (Actual)

April 8, 2020

Last Update Submitted That Met QC Criteria

April 6, 2020

Last Verified

April 1, 2020

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 314

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

No

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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