Detection of Microplastics in Cardiac Surgery Patients

Detection of Microplastics in Cardiac Surgery Patients: Its Metabolic Pathways and Toxic Effects

The exponential growth in plastic production/use translates into a parallel increase in environmental plastic waste, which is constantly degraded into microplastics and nanoplastics. Information on the effects of microplastics on human health is still preliminary.

Cardiac surgery patients is a population high exposed to plastics. This observational study will obtain biological samples of cardiac surgery patients as a reference and vulnerable group of individuals highly exposed to microplastics and potentially more susceptible.

The objective of this research is to be able to detect microplastics on blood and operation samples of cardiac surgery patients as well as their potential genotoxic and immunological damage.

Study Overview

• Status: Not yet recruiting
• Conditions: Cardiovascular Diseases; Cardiac Surgery; Microplastics; Nanoplastics
• Intervention / Treatment: Other: Microplastics

• Study Type: Observational
• Enrollment (Anticipated): 40

Contacts and Locations

• Study Contact: Name: Kun Hua, M.D.; Phone Number: +8615810111206; Email: huakun0310@126.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 80 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Cardiac surgery patients

Description

Inclusion Criteria:

• Age ≥18 years
• Elective cardiac surgery

Exclusion Criteria:

• Emergency surgery or limited-term surgery
• Previous cardiac surgery
• Previous severe liver disease
• Pregnant or planning to become pregnant
• Have a malignant tumor

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Retrospective

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Study group; Detection of microplastics/nanoplastics in heart tissue and the blood of patients undergoing cardiac surgery	Other: Microplastics; Detection of microplastics as a yes/no value

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Detection of microplastics in human heart tissue and the blood	Detection of microplastics in human heart tissue and the blood undergoing cardiac surgery	perioperative: preoperative and pro-/postoperative blood and intraoperative heart tissue

Collaborators and Investigators

• Sponsor: Kun Hua
• Investigators: Study Chair: Kun Hua, Beijing Anzhen Hospital

Study record dates

Study Major Dates

• Study Start (Anticipated): November 1, 2022
• Primary Completion (Anticipated): May 31, 2023
• Study Completion (Anticipated): October 22, 2023

Study Registration Dates

• First Submitted: October 26, 2022
• First Submitted That Met QC Criteria: October 26, 2022
• First Posted (Actual): October 31, 2022

Study Record Updates

• Last Update Posted (Actual): November 2, 2022
• Last Update Submitted That Met QC Criteria: October 31, 2022
• Last Verified: October 1, 2022

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Cardiovascular Diseases
• Other Study ID Numbers: default

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No