Profile of COVID-19 Patients Related to Fatigue

April 29, 2026 updated by: Irene Torres Sánchez, Universidad de Granada

More than half of recovered COVID-19 patients experience fatigue. Studies are needed to define the profile of these patients.

The objective of this study is to evaluate the profile of surviving patients of COVID-19 in relation to fatigue.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Detailed Description

Background: More than half of recovered COVID-19 patients experience fatigue. Studies are needed to define the profile of these patients.

Objectives: Evaluate the profile of surviving patients of COVID-19 in relation to fatigue;

Methodology: Observational study. The profile of the survivors of COVID-19 will be described, dividing them into 2 groups based on the presence or absence of fatigue.

Patients will be recruited from the Virgen de las Nieves University Hospital in Granada.

The evaluation will be carried out through Google forms, telematic means or face-to-face depending on the variables.

A symptomatic evaluation of fatigue, aspects related to fatigue and physical performance will be carried out.

Study Type

Observational

Enrollment (Estimated)

398

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Spain
    • Granada
      • Granada, Granada, Spain
        • University of Granada

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

COVID-19 patients

Description

Inclusion Criteria:

  • diagnosis of COVID-19
  • adults (>18 years)
  • basic knowledge and access to the internet
  • wish to participate in the study and sign the informed consent

Exclusion Criteria:

  • patients with severe comorbidities that interfere with the ability to perform the study, and those with mental, physical or organic problems that under medical criteria may pose a risk to the patient

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
COVID-19 patients
Other: Observational study
N/A - observational study.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Perceived Fatigue
Time Frame: Through study completion, an average of 1 year
To assess perceived fatigue using the borg modified scale. Scale ranges from 0 to 10, with higher punctuation indicating higher fatigue perception.
Through study completion, an average of 1 year
Multidimensional Fatigue
Time Frame: Through study completion, an average of 1 year
To assess multidimensional fatigue using the multidimensional fatigue inventory
Through study completion, an average of 1 year
Fatigue Severity
Time Frame: Through study completion, an average of 1 year
To assess fatigue severity using the fatigue severity scale. The total score ranges from 7 to 63 points, with higher punctuation indicating higher fatigue severity
Through study completion, an average of 1 year
Fatigue Impact
Time Frame: Through study completion, an average of 1 year
To assess fatigue impact using the modified fatigue impact scale. All items are scaled so that higher scores indicate a greater impact of fatigue on a person's activities. This scale can range from 0 to 36.
Through study completion, an average of 1 year
Muscular Fatigue
Time Frame: Through study completion, an average of 1 year
To assess muscular fatigue using surface electromyography
Through study completion, an average of 1 year

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
COVID-19 information
Time Frame: Through study completion, an average of 1 year
To assess information about the date and symptoms when COVID-19 was diagnosed
Through study completion, an average of 1 year
Dyspnea
Time Frame: Through study completion, an average of 1 year
To assess Dyspnea perception using the borg modified scale
Through study completion, an average of 1 year
Cough
Time Frame: Through study completion, an average of 1 year
To assess cough using the leicester cough questionnaire
Through study completion, an average of 1 year
Pain intensity
Time Frame: Through study completion, an average of 1 year
To assess pain intensity using the visual analogue scale and brief pain inventory
Through study completion, an average of 1 year
Functional status
Time Frame: Through study completion, an average of 1 year
To assess functional status using the post-covid functional scale and functional independence measure
Through study completion, an average of 1 year
Frailty
Time Frame: Through study completion, an average of 1 year
To assess frailty using the clinical frailty scale
Through study completion, an average of 1 year
Health-related Quality of life
Time Frame: Through study completion, an average of 1 year
To assess health-related quality of life using the euroqol-5d
Through study completion, an average of 1 year
Psychological status
Time Frame: Through study completion, an average of 1 year
To assess Psychological status using the hospital anxiety and depression scale
Through study completion, an average of 1 year
Sleep quality
Time Frame: Through study completion, an average of 1 year
To assess sleep quality using the Pittsburgh Sleep Quality Index
Through study completion, an average of 1 year
Nutritional status
Time Frame: Through study completion, an average of 1 year
To assess nutritional status using the mini nutritional assessment
Through study completion, an average of 1 year
Physical activity
Time Frame: Through study completion, an average of 1 year
To assess physical activity using the international physical activity questionnaire. This measure assesses the types of intensity of physical activity and sitting time that people do as part of their daily lives are considered to estimate total physical activity in Metabolic Equivalent (MET)-min/week and time spent sitting.
Through study completion, an average of 1 year
Kinesiophobia
Time Frame: Through study completion, an average of 1 year
To assess kinesiophobia using the TAMPA scale
Through study completion, an average of 1 year
Exercise capacity
Time Frame: Through study completion, an average of 1 year
To assess exercise capacity using the Short Physical Performance Battery and the 6 minutes walk test
Through study completion, an average of 1 year
Strength
Time Frame: Through study completion, an average of 1 year
To assess strength using dynamometry
Through study completion, an average of 1 year
Heart rate variability
Time Frame: Through study completion, an average of 1 year
To assess heart rate variability using holter
Through study completion, an average of 1 year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Universidad de Granada

Investigators

  • Principal Investigator: Irene Torres Sánchez, PhD, Universidad de Granada

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 15, 2023

Primary Completion (Actual)

September 30, 2024

Study Completion (Estimated)

September 30, 2026

Study Registration Dates

First Submitted

February 10, 2023

First Submitted That Met QC Criteria

February 14, 2023

First Posted (Actual)

February 16, 2023

Study Record Updates

Last Update Posted (Actual)

April 30, 2026

Last Update Submitted That Met QC Criteria

April 29, 2026

Last Verified

April 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • COVIDATE-01

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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