- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03600675
Determinants of Bone Mineral Density and Metabolic Syndrome in South Asian Indian Men
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
There is a rising minority population in the United States and South Asians make up the largest growing sub population. Health concerns in the minority population are several of which metabolic syndrome (MetS) and low bone mineral density (BMD) are important. Interestingly research in the past decade is beginning to suggest an interplay between bone and energy metabolism. Hormones, bone proteins and cytokines that play an important role in bone metabolism are also altered in metabolic syndrome, suggesting that both these
conditions may share a common etiology. Hence the primary question in this study would be to assess whether bone is altered in the South Asian population in the United States and whether hormones or other proteins regulating bone influence metabolic syndrome outcomes in the South Asians, specifically the South Asian Indian population. There is also an altered body composition in the South Asian Indian population with a greater visceral adiposity. Greater visceral adipose tissue (VAT) is associated in both the pathogenesis of metabolic syndrome and low BMD, possibly due to release of pro inflammatory cytokines. Interestingly several factors that are involved in the etiology of low BMD such as a greater visceral adiposity, high serum pro inflammatory cytokines, altered hormonal milieu such as low 25 hydroxy vitamin D (25OHD) and high parathyroid hormone (PTH), low osteocalcin levels, low calcium and high carbohydrate diet may share a relationship with MetS outcomes. The South Asian population has all the above-mentioned biochemical and metabolic alterations and it would be interesting to examine this in an immigrant Asian population residing in the USA. The investigators propose to examine 30 South Asian Indians between the ages of 30-50 years, using 30 resident Caucasian men as controls. Bone measures such as BMD and bone mineral content will be measured at radius, trochanter, hip and tibia and body composition including lean mass, fat mass, android fat and gynoid fat will be assessed using the Dual X ray energy absorptiometry (DXA). Biochemical measures including a complete metabolic panel, PTH, 25OHD, osteocalcin and other bone markers, and pro inflammatory cytokines will be measured in the serum. Investigators hypothesize that South Asian Indian men will have a lower BMD and higher MetS risk factors compared to age and BMI matched Caucasian men. Investigators further propose that common biochemical and metabolic alterations will underlie both low BMD and MetS outcomes in SAI population, but not in the Caucasian population. Identification of common determinants will help design a single future interventional trial that will target both MetS and bone health in the SA population
Specific Aim 1 To determine whether Bone Mineral Density (BMD) at weight-bearing and non weight-bearing sites is lower in age- and weight-matched SAI compared to white men.
It is hypothesized that SAI men will have lower BMD at weight-bearing sites compared to age and BMI-matched white men.
Specific Aim 2 To determine whether body composition influences Bone Mineral Density in SAI men.
It is hypothesized that greater abdominal adiposity, specifically visceral fat, influences BMD in SAI men compared to age- and BMI-matched white men.
Specific Aim 3 To examine the hormonal, inflammatory, and dietary determinants of Bone Mineral Density and MetS in SAI compared to white men.
It is hypothesized that the hormonal, inflammatory, and dietary determinants of both MetS and low BMD will be similar in the SAI men but not in the white men.
This study will involve one single visit. The following will be conducted during this visit:
- This visit will last for about 2 hours
- Blood draw- Four 5 ml tubes of blood will be collected via venipuncture
- Spot urine sample collection
- Measurement of height, weight, blood pressure, waist circumference
- Completion of study questionnaires
- DXA scan
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
Pennsylvania
-
Philadelphia, Pennsylvania, United States, 19102
- Drexel University Nutrition Sciences Research Lab
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
South Asians Indians are defined as those who can trace their ancestry to Bangladesh, Bhutan, India, the Maldives, Nepal, Pakistan, and Sri Lanka.
Caucasians are defined as non-Hispanic who do not belong to any other ethnic group.
Description
Inclusion Criteria:
- South Asian Indian and Caucasian males
- 20 and 50 years of age
- BMI range 23 - 35 kg/m2
Exclusion Criteria:
- An individual is unwilling to sign the informed consent document.
- A physician states that a participant is not able to participate in the study.
- Individuals with the presence of any acute illness in the past month.
- Individuals with preexisting chronic medical conditions such as diabetes (type I and II), cancer, other metabolic disorders.
- Individuals who are using medications known to influence bone, blood glucose, lipids,and blood pressure.
- Individuals who had a history of major diseases, such as cardiac, diabetes, renal, or evidence of cancer, in the past year.
Study Plan
How is the study designed?
Design Details
- Observational Models: Other
- Time Perspectives: Cross-Sectional
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
South Asian Indians
No intervention will be applied for any group
|
No intervention will be applied to any group.
It is an observational study and all measurements are collected during one visit.
Other Names:
|
Caucasians
No intervention will be applied for any group
|
No intervention will be applied to any group.
It is an observational study and all measurements are collected during one visit.
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Bone Mineral Density ( g/cm2)
Time Frame: 1 day at baseline
|
Baseline differences in BMD in 2 groups
|
1 day at baseline
|
Total Body fat ( kg)
Time Frame: 1 day at baseline
|
Using the total body scan from the DXA , fat mass will be assessed
|
1 day at baseline
|
Lean mass ( Kg)
Time Frame: 1 day at baseline
|
Using the total body scan from the DXA , lean mass will be assessed
|
1 day at baseline
|
Visceral adipose tissue - VAT ( kg)
Time Frame: 1 day at baseline
|
Using the total body scan from the DXA ,VAT mass will be assessed
|
1 day at baseline
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Interleukin-6 ( IL-6)- pg/mL
Time Frame: 1 day at baseline
|
Serum levels will be assayed
|
1 day at baseline
|
Monocyte Chemoattractant protein-1 ( MCP-1)- ng//mL
Time Frame: 1 day at baseline
|
Serum levels will be assayed
|
1 day at baseline
|
C- Reactive Protein ( CRP)-mg/L
Time Frame: 1 day at baseline
|
Serum levels will be assayed
|
1 day at baseline
|
Adiponectin- ng/mL
Time Frame: 1 day at baseline
|
Serum levels will be assayed
|
1 day at baseline
|
Lipid profile
Time Frame: 1 day
|
Serum levels of HDL, LDL, Total cholesterol and triglycerides will be assayed ( mg/dL)
|
1 day
|
Blood pressure
Time Frame: 1 day
|
1 day
|
|
beta-C-terminal telopeptide (CTx) - ug/L
Time Frame: 1 day
|
Serum levels will be assayed
|
1 day
|
Parathyroid hormone- pg/mL
Time Frame: 1 day
|
Serum levels will be assayed
|
1 day
|
25 hydroxy vitamin D- ng/ML
Time Frame: 1 day
|
Serum levels will be assayed
|
1 day
|
Osteocalcin ( total)- ng/mL
Time Frame: 1 day
|
Serum levels will be assayed
|
1 day
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Deeptha Sukumar, PhD, Drexel University
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 1604004460R001
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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