ENDOMETRIOSIS - MRI (ENDO-MRI)

Study of Pelvic Organ Mobility by Dynamic MRI in Pelvic Endometriosis

Endometriosis is a frequent pathology with an estimated prevalence of 10% of women of childbearing age. There is no exact correspondence between the symptoms described by the patients and the severity of the lesions, which makes clinical diagnosis difficult. It therefore seems important to improve the complementary examinations available to make the diagnosis more precise and to better study the effectiveness of the treatments implemented. The clinical examination and per-surgical findings of patients with deep pelvic endometriosis show a clear decrease in the mobility of the pelvic organs in relation to each other, but few studies have looked at this mobility, which could however have an implication in explaining the pathophysiology of the disease and the symptomatology of the patients, as well as in the detection of lesions preoperatively. The persistence of hypo-mobility could also help to understand treatment failures.

Study Overview

• Status: Recruiting
• Conditions: Endometriosis; Magnetic Resonance Imaging; Mobility Limitation; Diagnosis; Pelvis; Comparative Study
• Intervention / Treatment: Other: Dynamic MRI Sequence

• Study Type: Observational
• Enrollment (Estimated): 52

Contacts and Locations

• Study Contact: Name: Chrystele RUBOD, MD,PhD; Phone Number: 0320445962; Email: chrystele.rubod@chru-lille.fr

Study Locations

• France
  • Lille, France
    • Recruiting
    • Service de chirurgie gynécologique Hôpital Jeanne de Flandre - CHU de LILLE
    • Contact: CHRYSTELE RUBOD DIT GUILLET,; Phone Number: 0320446757; Email: chrystele.rubod@chru-lille.fr

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 50 years (Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

The population concerns patients referred to the Lille University Hospital for suspected pelvic endometriosis

Description

Inclusion Criteria:

• Patient referred for suspected pelvic endometriosis requiring pelvic MRI
• Female, nulliparous,
• patient with signed written consent, patient with health insurance,
• patient willing to comply with all study procedures and duration

Exclusion Criteria:

• BMI > 35,
• history of hereditary collagen and elastic tissue disease,
• history of pelviperitonitis,
• history of major pelvic surgery,
• inability to receive informed information,
• inability to participate in the entire study,
• lack of social security coverage,
• refusal to sign consent

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
patients with pelvic endometriosis; Patients referred for suspected pelvic endometriosis, with pelvic endometriosis on initial MRI	Other: Dynamic MRI Sequence; Addition of a Dynamic MRI Sequence during the MRI examination performed in routine care
patients without pelvic endometriosis; Patients referred for suspected pelvic endometriosis but without endometriosis found on diagnostic MRI.	Other: Dynamic MRI Sequence; Addition of a Dynamic MRI Sequence during the MRI examination performed in routine care

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
the mean vertical displacement (in millimeters) measured on the anterior wall of the vagina between rest and maximum pushing force during dynamic MRI	Baseline

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
the mean vertical displacement (in millimetres) measured on the cervix between rest and maximum thrust effort during dynamic MRI.		Baseline
the mean vertical displacement (in millimetres) measured on the posterior wall of the vagina between rest and maximum pushing force during dynamic MRI.		Baseline
the measurement of variation in mean vertical displacement (in millimetres) on the wall of each pelvic organ at the push effort between the initial dynamic MRI of patients with		Baseline
the statistical association between the symptoms of patients with endometriosis and the mean vertical displacement (in millimetres) on the wall of each pelvic organ at the push effort during dynamic MRI.	Initial symptoms are associated with initial dynamic MRI data and post therapeutic symptoms are associated with post-therapeutic dynamic MRI data. The symptoms of interest are dysmenorrhea, non-cyclic pelvic pain, dysuria, dychesia, transit disorders (diarrhea/constipation), and dyspareunia.	Baseline

Collaborators and Investigators

• Sponsor: University Hospital, Lille
• Investigators: Principal Investigator: Chrystele RUBOD, MD,PhD, University Hospital, Lille

Study record dates

Study Major Dates

• Study Start (Actual): May 23, 2023
• Primary Completion (Estimated): July 1, 2026
• Study Completion (Estimated): July 1, 2026

Study Registration Dates

• First Submitted: March 9, 2023
• First Submitted That Met QC Criteria: March 9, 2023
• First Posted (Actual): March 22, 2023

Study Record Updates

• Last Update Posted (Actual): December 26, 2025
• Last Update Submitted That Met QC Criteria: December 18, 2025
• Last Verified: December 1, 2025

More Information

Terms related to this study

• Keywords: Comparative Study; Pelvis; Mobility Limitation; Endometriosis ;; Magnetic Resonance Imaging, Cine
• Additional Relevant MeSH Terms: Urogenital Diseases; Genital Diseases; Pathologic Processes; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Genital Diseases, Female; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Disease; Mobility Limitation; Endometriosis
• Other Study ID Numbers: 2022_0032; 2022-A02135-38 (Other Identifier: ID-RCB number, ANSM)

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No