Gamified Adaptive Approach Bias Modification on Individuals With Methamphetamine Use History

A randomized controlled trial will be conducted to investigate whether a proposed algorithm that adjusts the congruency ratio based on the user's performance and difficulty can enhance the effectiveness of approach bias modification. Methamphetamine users will be recruited and randomized into an algorithm group, a standard group, and a control group.

Study Overview

• Status: Completed
• Conditions: Addiction, Substance
• Intervention / Treatment: Behavioral: Adaptive Approach Bias Modification; Behavioral: Static Approach Bias Modification

Detailed Description

To assess the efficacy of an adaptive approach bias modification (A-ApBM) paradigm with gamified designs and dynamic difficulty adjustments in reducing cue-induced craving in individuals with methamphetamine use history. DESIGN: Randomized controlled trial with three study groups: Adaptive ApBM (A-ApBM), Static ApBM (S-ApBM), and control. A-ApBM and S-ApBM groups engaged in ApBM training using a smartphone application for four weeks. A-ApBM used an adaptive algorithm to dynamically adjust the difficulty level based on individual performance, while S-ApBM had a static difficulty level. Cue-induced craving scores were assessed using a visual analog scale at baseline, post-intervention, and at week-16 follow-up.

• Study Type: Interventional
• Enrollment (Actual): 139
• Phase: Not Applicable

Contacts and Locations

Study Locations

• China
  • Sichuan
    • Guanghan, Sichuan, China
      • Gao Ping Town Community Drug Rehabilitation Center
    • Guanghan, Sichuan, China
      • Han Zhou Street Community Drug Rehabilitation Center
    • Guanghan, Sichuan, China
      • Jin Lun Town Community Drug Rehabilitation Center
    • Guanghan, Sichuan, China
      • Jin Yan Street Community Drug Rehabilitation Center
    • Guanghan, Sichuan, China
      • Jin Yu Town Community Drug Rehabilitation Center
    • Guanghan, Sichuan, China
      • Lian Shan Town Community Drug Rehabilitation Center
    • Guanghan, Sichuan, China
      • Nan Feng Town Community Drug Rehabilitation Center
    • Guanghan, Sichuan, China
      • San Shui Town Community Drug Rehabilitation Center
    • Guanghan, Sichuan, China
      • Sanxingdui Town Community Drug Rehabilitation Center
    • Guanghan, Sichuan, China
      • SixTwentySix Service Center, Luo Cheng Street, Guanghan City
    • Guanghan, Sichuan, China
      • Xiang Yang Town Community Drug Rehabilitation Center
    • Guanghan, Sichuan, China
      • Xiao Han Town Community Drug Rehabilitation Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 55 years (Adult)
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• having a history of methamphetamine use of at least one year

Exclusion Criteria:

• could not fluently operate an Android or an iOS smartphone
• having mental health conditions other than MUD

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
No Intervention: Control
Experimental: Adaptive Approach Bias Modification	Behavioral: Adaptive Approach Bias Modification; In the adaptive approach bias modification, users were instructed to swipe upward when they see portrait format images and swipe downward when they see landscape format images. A shrinking animation comes after swiping upward to simulate the visual effect of moving away (approach), and a growing animation comes after swiping downward to simulate the visual effect of moving towards (avoidance). Two types of images, namely drug-related and non-drug-related, were used in the training. The drug-related images were related to methamphetamine (methamphetamine crystals, powders, and paraphernalia), and the non-drug-related images were related to healthy lifestyles (wealth, sports, gourmet, family activities, etc). An algorithm continuously monitors the performance of the user and adjusts the ratio of congruent and incongruent trials accordingly to attain a desired difficulty curve.
Experimental: Static Approach Bias Modification	Behavioral: Static Approach Bias Modification; In the static approach bias modification, users were instructed to swipe upward when they see portrait format images and swipe downward when they see landscape format images. A shrinking animation comes after swiping upward to simulate the visual effect of moving away (approach), and a growing animation comes after swiping downward to simulate the visual effect of moving towards (avoidance). Two types of images, namely drug-related and non-drug-related, were used in the training. The drug-related images were related to methamphetamine (methamphetamine crystals, powders, and paraphernalia), and the non-drug-related images were related to healthy lifestyles (wealth, sports, gourmet, family activities, etc).

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Cue induced craving for methamphetamine	The cue-induced craving was assessed by showing the participants images related to methamphetamine (methamphetamine crystals, powders, and paraphernalia) on a smartphone and asking them to rate their cravings on a 0-10 visual analog scale (0 being least craved and 10 being most craved).	Baseline
Cue induced craving for methamphetamine	The cue-induced craving was assessed by showing the participants images related to methamphetamine (methamphetamine crystals, powders, and paraphernalia) on a smartphone and asking them to rate their cravings on a 0-10 visual analog scale (0 being least craved and 10 being most craved).	Immediately Post-intervention
Cue induced craving for methamphetamine	The cue-induced craving was assessed by showing the participants images related to methamphetamine (methamphetamine crystals, powders, and paraphernalia) on a smartphone and asking them to rate their cravings on a 0-10 visual analog scale (0 being least craved and 10 being most craved).	16 week from baseline assesment

Collaborators and Investigators

• Sponsor: Adai Technology (Beijing) Co., Ltd.

Study record dates

Study Major Dates

• Study Start (Actual): March 10, 2023
• Primary Completion (Actual): July 15, 2023
• Study Completion (Actual): July 15, 2023

Study Registration Dates

• First Submitted: March 6, 2023
• First Submitted That Met QC Criteria: March 20, 2023
• First Posted (Actual): April 3, 2023

Study Record Updates

• Last Update Posted (Actual): July 18, 2023
• Last Update Submitted That Met QC Criteria: July 17, 2023
• Last Verified: July 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Mental Disorders; Chemically-Induced Disorders; Substance-Related Disorders
• Other Study ID Numbers: TS001

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No