Evolution of Pulsed Oxygen Saturation During Interval Training Compared to Continuous Training in COPD Patients

Evolution of Pulsed Oxygen Saturation Throughout an Interval Training Session Compared to a Continuous Training Session in Patients With Chronic Obstructive Pulmonary Disease With Exercise-induced Oxygen Desaturation.

A problem often observed during exercise training is oxygen desaturation exclusively during exercise in some patients. In the case of exercise-induced desaturation, it may be suggested to train these patients in interval training to limit exercise-induced desaturation. Interval training consists of alternating active phases of short duration (often 30 seconds to 1 minute) followed by a short active or passive recovery phase of equivalent duration to the previous phase. Investigators therefore hypothesise that interval training on a cycloergometer or treadmill can limit exercise-induced desaturation in COPD patients.

The aim of the study is to observe the evolution of pulsed oxygen saturation between a continuous training session and a interval training session.

Study Overview

• Status: Completed
• Conditions: Exercise; Pulmonary Rehabilitation; COPD; Desaturation of Blood
• Intervention / Treatment: Other: Continuous training session; Other: Interval training session

• Study Type: Observational
• Enrollment (Actual): 12

Contacts and Locations

Study Locations

• France
  • Normandy
    • Le Havre, Normandy, France, 76290
      • Groupe Hospitalier Du Havre

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Patients with COPD who meet the inclusion criteria will be offered to participate in this study during a pulmonary rehabilitation programme which will take place in the pneumology rehabilitation department of the Le Havre Hospital. If the patient wishes to participate in the study, he/she will be given an information note containing a declaration of non-opposition which he/she will have to complete and sign.

Description

Inclusion Criteria:

• a diagnosis of COPD
• participating in a pulmonary rehabilitation programme
• with an exercise-induced desaturation less than 90%
• no oxygen supplementation

Exclusion Criteria:

• Under 18 years of age
• Pregnant woman
• Person not affiliated to a health insurance regime or not benefiting from a social security regime
• Patient under curatorship, guardianship or safeguard of justice
• Patient speaking a language other than French
• Patient with severe hypoxaemia (SpO2 ≤ 80%) during exercise
• Patient having had a moderate or severe exacerbation (hospitalisation for respiratory reasons) in the previous 4 weeks
• Patients with orthopaedic, rheumatic, vascular or neurological pathology limiting their ability to make an effort
• Breastfeeding women

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Continuous training session	Other: Continuous training session; Continuous training consists of a 5 minute warm up, 5 minute cool down and 20 minutes of moderate intensity work. The workload is set at 60% of the patient's maximum power
Interval Training session	Other: Interval training session; Interval training consists of a 5-minute warm-up, a 5-minute cool-down and 20 minutes of alternating 60 seconds of high-intensity work (100% of the maximum power recorded in the incremental test that was carried out when the patient was admitted to the pulmonary rehabilitation department) and 60 seconds of unloaded pedalling or rest.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Difference in oxygen pulsed saturation	Difference in minimum saturation during both exercise, the measurement will be performed with a pulse oximeter (Spirodoc, MIR)	One week

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Difference in oxygen pulsed saturation	Difference in mean pulsed oxygen saturation and the time spent with a pulsed oxygen saturation below 90% during the two training sessions. The measurement will be performed with a pulse oximeter (Spirodoc, MIR)	One week
Difference in peripheral muscle oxygenation	Muscle oxygenation (arbitrary unit) will be evaluated using Near-infrared spectroscopy technology. the measurement will be performed with a Near Infrared spectroscopy (Portamon, Artinis Medical Systems)	One week
Difference in respiratory rate	Difference in respiratory rate will be measured breath-by-breath using a portable spirometer (Spirodoc, MIR)	One week
Difference in tidal volume	Difference in tidal volume will be measured breath-by-breath using a portable spirometer (Spirodoc, MIR)	One week
Difference in inspiratory capacity	Difference in inspiratory capacity will be measured using a portable spirometer (Spirodoc, MIR)	One week
Difference in Dyspnea	Dyspnea peak during exercise using the modified Borg scale 0-10, 0 no dyspnea, 10 maximal dyspnea	One week
Difference in muscle discomfort	Muscle discomfort peak during exercise using the modified Borg scale 0-10, 0 no dyspnea, 10 maximal dyspnea	One week

Collaborators and Investigators

• Sponsor: Groupe Hospitalier du Havre
• Collaborators: Medrinal Clement; Combret Yann; Machefert Margaux
• Investigators: Principal Investigator: Guillaume Prieur, PT, PhD, Groupe Hospitalier Du Havre

Study record dates

Study Major Dates

• Study Start (Actual): January 10, 2023
• Primary Completion (Actual): September 30, 2025
• Study Completion (Actual): October 10, 2025

Study Registration Dates

• First Submitted: January 10, 2023
• First Submitted That Met QC Criteria: April 11, 2023
• First Posted (Actual): April 24, 2023

Study Record Updates

• Last Update Posted (Actual): January 21, 2026
• Last Update Submitted That Met QC Criteria: January 18, 2026
• Last Verified: January 1, 2026

More Information

Terms related to this study

• Keywords: COPD; Pulmonary rehabilitation; Interval training
• Additional Relevant MeSH Terms: Pathologic Processes; Chronic Disease; Disease Attributes; Respiratory Tract Diseases; Lung Diseases; Lung Diseases, Obstructive; Pathological Conditions, Signs and Symptoms; Behavior; Pulmonary Disease, Chronic Obstructive; Motor Activity
• Other Study ID Numbers: 2022-A02087-36

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES
• IPD Plan Description: deidentified participtant data
• IPD Sharing Time Frame: after publication
• IPD Sharing Access Criteria: the request shall be sent to Guillaume Prieur (gprieur.kine@gmail.com)
• IPD Sharing Supporting Information Type: SAP; CSR

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No