Evaluation of Metabolic Syndrome, Frailty, Locomotive Syndrome, Balance and Physical Fitness in Elderly Individuals

Metabolic syndrome (MetS) or syndrome X, which is increasingly prevalent in the world and in our country, is a disease that includes abdominal obesity, dyslipidemia, impaired glycemic control and hypertension components. It causes cardiovascular events such as myocardial hypertrophy, left ventricular diastolic dysfunction, atrial dilatation and atrial fibrillation. Low levels of physical activity can be caused by a wide variety of factors including environmental and genetic factors, age, race, sarcopenia, poor eating habits, postmenopausal period and smoking history. Factors such as genetic differences, diet, physical activity, age, gender and eating habits are reported to affect the prevalence of (MetS) and its components. Frailty is also emerging as a major issue for the elderly due to its debilitating effects on health outcomes. Frailty is a geriatric syndrome characterized by a gradual decrease in homeostatic tolerance and physiological reserve following exposure to stressors. Frailty predisposes older people to falls, delirium, hospitalizations and even death and is therefore considered a crucial transition between healthy ageing and disability. As a result of aging, degenerative changes in the central and peripheral vestibular system have been found. With age, the ability to regulate movement is impaired as a result of insufficient information in any of the sensory receptors or any disorder affecting the processing of these messages. This directly affects balance and postural control, leading to an increased risk of falls. In the light of the results of the studies in the literature, degenerative changes are observed in many systems in geriatric individuals and while the incidence of metabolic syndrome in these individuals is high, the number of studies evaluating their effects is not sufficient. Based on these deficiencies, it is aimed to examine metabolic syndrome, frailty, locomotive syndrome, balance and physical fitness in elderly individuals.

Study Overview

• Status: Completed
• Conditions: Geriatrics; Physical Fitness; Balance; Fragility; Locomotor
• Intervention / Treatment: Other: observational physical tests

• Study Type: Observational
• Enrollment (Actual): 41

Contacts and Locations

Study Locations

• Turkey (Türkiye)
  • Kırıkkale
    • Kırıkkale, Kırıkkale, Turkey (Türkiye), 71450
      • Kırıkkale University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Older Adult
• Accepts Healthy Volunteers: N/A

• Sampling Method: Non-Probability Sample

Study Population

Individuals aged 65 and over, 10 individuals

Description

Inclusion Criteria:

• Individuals aged 65 and over,
• Volunteering to participate in the research
• No cooperation and communication problems

Exclusion Criteria:

• Individuals with neurological and orthopedic problems
• Uncontrolled hypertension
• Those with cardiac disorders
• Those with cooperation and communication problems

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort

Intervention / Treatment

geriatrics individuals

Other: observational physical tests; Geriatric Locomotive Function Scale: This scale consists of a questionnaire of 25 items that can be easily understood by the elderly and each item is graded between 0 and 4 points. The total score is the result of the sum of all items ranging from 0 to 100; the higher the score, the higher the physical impairment of the elderly, with a score of 16 being the cut-off point for locomotive syndrome. The GLFS-25 includes 4 questions about pain, 16 questions about activities of daily living, 3 questions about social performance and 2 questions about mental health status to assess geriatric individuals. Turkish validity and reliability of the questionnaire was conducted by Sadikoglu.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Geriatric Locomotive Function Scale:	This scale consists of a questionnaire of 25 items that can be easily understood by the elderly and each item is graded between 0 and 4 points. The total score is the result of the sum of all items ranging from 0 to 100; the higher the score, the higher the physical impairment of the elderly, with a score of 16 being the cut-off point for locomotive syndrome. The GLFS-25 includes 4 questions about pain, 16 questions about activities of daily living, 3 questions about social performance and 2 questions about mental health status to assess geriatric individuals. Turkish validity and reliability of the questionnaire was conducted by Sadikoglu.	10 minute

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Chair sit-lie test	The patient is asked to sit and stand as quickly as possible in a chair with a seat height of 43.2 cm and a supported back. The patient sits on the chair.He crosses his hands on his chest. 2 attempts are made before the test. A stopwatch is kept for 30 seconds and the number of sit-ups is noted. Less than 10 sit-ups in 30 seconds indicates lower extremity muscle weakness	5 minute
Two-minute step test	It is applied to evaluate aerobic endurance. In order to perform the test correctly, the distance at which the participant will lift the knee is determined as the midpoint between the knee joint and the crista iliaca and marked on the wall. For a better understanding of the test is demonstrated practically. The participant is asked to start with the right foot and rhythmically raise their feet to the marked height for 2 minutes. The number of standardized right steps repeated for two minutes is recorded as a score.	2 minute
Weight lifting test	It is applied to evaluate upper extremity muscle strength. Participant's feet is asked to sit towards the side of the chair while on the floor. The participant is asked to bend and extend their arms by lifting the dumbbell with the given instruction. As weight dumbbells of 3.63 kg for men (8-lb) and 2.27 kg for women (5-lb) are used. For a better understanding of the test, it was demonstrated and practiced. In the test, the maximum possible number of repetitions performed with the dominant arm for 30 s is considered as the score.	2 minute

Collaborators and Investigators

• Sponsor: Kırıkkale University

Study record dates

Study Major Dates

• Study Start (Actual): June 1, 2023
• Primary Completion (Actual): November 1, 2024
• Study Completion (Actual): January 20, 2025

Study Registration Dates

• First Submitted: July 3, 2023
• First Submitted That Met QC Criteria: July 3, 2023
• First Posted (Actual): July 10, 2023

Study Record Updates

• Last Update Posted (Actual): December 24, 2025
• Last Update Submitted That Met QC Criteria: December 18, 2025
• Last Verified: July 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Glucose Metabolism Disorders; Metabolic Diseases; Insulin Resistance; Hyperinsulinism; Metabolic Syndrome; Frailty
• Other Study ID Numbers: Gurbuz02

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No