The Risk Factors of Thrombosis in Complicated Arteriovenous Fistula

July 22, 2023 updated by: Mohamed Aldosouky, Assiut University

The Risk Factors of Thrombosis in Complicated Arteriovenous Fistula in Patients on Regular Hemodialysis

study the risk factors of thrombosis in thrombosed arteriovenous fistula in patients on regular hemodialysis

Study Overview

Status

Not yet recruiting

Conditions

Detailed Description

The number of patients being treated for kidney failure continues to increase every year at a significantly higher rate than that of the world population.

The main renal replacement therapy was hemodialysis (HD) in 57% patients and peritoneal dialysis in 5% patients, while 37% patients underwent a functional kidney transplant.

Native arteriovenous fistula (AVF) is currently the best VA when technically feasible, according to the international dialysis guidelines.

Hemodialysis vascular access failure is the dominant cause of morbidity and the major cost of care for end-stage renal disease (ESRD) patients .

Complications such as thrombosis of VA remain the main problem for many patients with kidney failure.

Since 1994, prospective and case-control studies have explored the relationship between risk factors and arteriovenous fistula thrombus (AVFT) in patients undergoing HD .

Until now, these studies and reviews have revealed that numerous risk factors are associated with AVFT .

Risk factors like arterio-venous graft, age, female sex, C-reactive protein level, fistula site (distal), hypertension and the use of eprex can be associated with AVFT, and this knowledge advances the understanding of AVFT, facilitates multivariable risk prediction profiling, and lays the foundation for future preventive strategies .

Study Type

Observational

Enrollment (Estimated)

69

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

N/A

Sampling Method

Non-Probability Sample

Study Population

patients on maintenance hemodialysis treatment at the dialysis unit of the department of nephrology in Assiut University Hospital .

Description

Inclusion Criteria:

  • All patients on maintenance hemodialysis treatment at the dialysis unit of the department of nephrology in Assiut University Hospital .

Exclusion Criteria:

  • Patients with known other risk factors of thrombosis, e.g., malignancy, pregnancy, cocs and nephrotic syndrome.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Detection of the risk factors of thrombosis in complicated AV Fistula in patients on regular hemodialysis
Time Frame: 1 week following AV Fistula occlusion
Provide the evidence on the association between potential risk factors and arteriovenous fistula thrombus
1 week following AV Fistula occlusion

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Assiut University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

December 1, 2023

Primary Completion (Estimated)

December 1, 2024

Study Completion (Estimated)

January 1, 2025

Study Registration Dates

First Submitted

July 13, 2023

First Submitted That Met QC Criteria

July 22, 2023

First Posted (Actual)

July 27, 2023

Study Record Updates

Last Update Posted (Actual)

July 27, 2023

Last Update Submitted That Met QC Criteria

July 22, 2023

Last Verified

July 1, 2023

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • AV fistula thrombosis

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Arteriovenous Fistula Thrombosis

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Thailand

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe