Nasal Anatomical and Pathological Variants in Patients With Antrochoanal Polyps

The goal of this observational study is to learn about anatomical and pathological variants in patients with antrochoanal polyps trying to find a key to its pathogenesis Participants will have nasal endoscopic examination and CT nose and paranasal sinuses.

we will compare patients with antrochoanal polyps and other patients with unilateral sinonasal disease regarding anatomical and pathological variants.

Study Overview

• Status: Completed
• Conditions: Antrochoanal Polyp
• Intervention / Treatment: Other: CT scan for nose and paranasal sinuses

Detailed Description

This study was conducted at Otolaryngology department, Minia University Hospital, Minia, Egypt. The study was approved by the Institutional Review Board at Minia University.

The study participants were recruited from patients complaining from unilateral sinonasal disease attending outpatient clinic.

we selected 40 patients with ACPs who had the following inclusion criteria: 1-radiologically diagnosed based on CT nose and PNS. 2-histopathologically diagnosed as ACP. The radiological diagnosis is based on seeing low attenuated soft tissue mass filling the maxillary antrum and extending through the middle meatus into the nasal cavity and directs towards the post nasal opening. We excluded: 1- patients with history of maxillofacial trauma. 2- patients who had previous nasal surgery.

To be more objective, a control group of 40 patients who had unilateral sinonasal disease other than ACP was formed.

We assessed multislice computed tomography (CT) nose and paranasal sinus images by Toshiba aquilion CT scanner. Axial and coronal 250mm cuts were obtained.

Both study and control groups were compared regarding anatomical and pathological variations in the nose. These variants include: deviated nasal septum, concha bullosa, paradoxical middle turbinate and uncinate process insertion (to lamina papyrecea or roof of ethmoid or middle turbinate). We also compare between them according to presence of retention cyst in CT in contralateral side In the cases with deviated nasal septum, the septal deviation was seen if it is towards the side of the lesion or towards the opposite side according to its convexity.

We also evaluate the sclerosis on thickening of the bony wall of the para nasal sinus as an indication of chronic inflammation.

SPSS 24.0 program was used for statistical analysis. Averages and standard deviations were calculated. The Mann-Whitney and Chi square tests were used for comparisons between the groups. The Pearson correlation tests was used to evaluate correlations. Statistical significance was set at ≤ 0.05.

• Study Type: Observational
• Enrollment (Actual): 80

Contacts and Locations

Study Locations

• Egypt
  • Minya, Egypt
    • Faculty of medicine

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

The study participants were recruited from patients complaining from unilateral sinonasal disease attending our outpatient clinic.

Description

Inclusion Criteria:

1. radiologically diagnosed based on CT nose and PNS.
2. histopathologically diagnosed as ACP.

Exclusion Criteria:

1. patients with history of maxillofacial trauma.
2. patients who had previous nasal surgery.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
study group; patients with antrochoanal polyps	Other: CT scan for nose and paranasal sinuses; CT scan for nose and paranasal sinuses
control group; patients with unilateral sinonasal disease other than antrochoanal polyps	Other: CT scan for nose and paranasal sinuses; CT scan for nose and paranasal sinuses

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
presence of anatomical and pathological variants in CT scan and endoscopic examination	Both study and control groups were compared regarding anatomical and pathological variations in the nose. These variants include: deviated nasal septum, concha bullosa, paradoxical middle turbinate and uncinate process insertion (to lamina papyrecea or roof of ethmoid or middle turbinate). We also compare between them according to presence of retention cyst in CT in contralateral side In the cases with deviated nasal septum, the septal deviation was seen if it is towards the side of the lesion or towards the opposite side according to its convexity. We also evaluate the sclerosis on thickening of the bony wall of the para nasal sinus as an indication of chronic inflammation.	6 months

Collaborators and Investigators

• Sponsor: Minia University

Study record dates

Study Major Dates

• Study Start (Actual): December 20, 2022
• Primary Completion (Actual): July 30, 2023
• Study Completion (Actual): August 30, 2023

Study Registration Dates

• First Submitted: August 5, 2023
• First Submitted That Met QC Criteria: August 5, 2023
• First Posted (Actual): August 14, 2023

Study Record Updates

• Last Update Posted (Estimated): November 16, 2023
• Last Update Submitted That Met QC Criteria: November 15, 2023
• Last Verified: November 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Respiratory Tract Diseases; Otorhinolaryngologic Diseases; Pathological Conditions, Anatomical; Nose Diseases; Nasal Polyps; Polyps
• Other Study ID Numbers: 538-2022

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No