Application of New Magnetic Resonance UTE Technique in Hip Joint Lesions

Application of New Magnetic Resonance Technique-UTE in Hip Joint Lesions

Explore the imaging and quantitative monitoring of hip bone, cartilage and ligament by magnetic resonance UTE technology, combined with QCT and DXA technology, to provide a more accurate basis for clinical evaluation and treatment.

Study Overview

• Status: Recruiting
• Conditions: Hip Disease

Detailed Description

Osteoporosis is a systemic bone metabolism-related disease characterized by decreased bone mass per unit volume, increased bone fragility, decreased bone density, thinning of the bone cortex and changes in bone microstructure. It often occurs in the lumbar spine and hip joint. Femoral neck fracture is a common complication of hip osteoporosis, which seriously affects people's quality of life. UTE technology can clearly image and quantify human cortical bone and cancellous bone, and advanced UTE technology such as STAIR-UTE and UTE-MT have made some progress in the field of osteoporosis. The purpose of this study was to explore UTE technology for imaging and quantitative study of cortical bone, cancellous bone and cartilage of hip joint, and to find more accurate imaging methods for clinical evaluation of hip osteoporosis and other diseases.

• Study Type: Observational
• Enrollment (Estimated): 150

Contacts and Locations

• Study Contact: Name: Xiaojun Chen; Phone Number: +8615820587112; Email: 422175400@qq.com

Study Locations

• China
  • Guangdong
    • Zhuhai, Guangdong, China, 519000
      • Recruiting
      • Radiography department
      • Contact: Xiaojun Chen; Phone Number: +8615820587112; Email: 422175400@qq.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Patients who meet the inclusion criteria

Description

Inclusion Criteria:

1. Patients with past or suspected osteoporosis and bone loss;
2. Patients with previous femoral neck fracture;
3. Patients with avascular necrosis of femoral head;
4. Hip osteoarthritis patients.

Exclusion Criteria:

1. Patients with metal implants in corresponding parts;
2. Claustrophobic.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
normal group; There are no lesions on the hip.
abnormal group; There are some lesions on the hip.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
proton density fat fraction (PDFF)	Magnetic resonance proton density fat fraction	Baseline (before surgery)
T2 relaxation rate	R2*	Baseline (before surgery)
Magnetization Transfer Ratio (MTR)	magnetization transfer ratio	Baseline (before surgery)
T1rho	spin-lattice relaxation in the rotation ame	Baseline (before surgery)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Subjective rating values	rating values	Baseline (before surgery)

Collaborators and Investigators

• Sponsor: Fifth Affiliated Hospital, Sun Yat-Sen University
• Investigators: Study Director: Shaolin Li, Fifth Affiliated Hospital, Sun Yat-Sen University

Study record dates

Study Major Dates

• Study Start (Actual): July 1, 2023
• Primary Completion (Estimated): June 13, 2024
• Study Completion (Estimated): June 13, 2024

Study Registration Dates

• First Submitted: August 2, 2023
• First Submitted That Met QC Criteria: August 17, 2023
• First Posted (Actual): August 21, 2023

Study Record Updates

• Last Update Posted (Actual): August 21, 2023
• Last Update Submitted That Met QC Criteria: August 17, 2023
• Last Verified: August 1, 2023

More Information

Terms related to this study

• Other Study ID Numbers: ZDWY.FSK.025

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No