Physical Parameters in Osteoarthritis Stages

Effects Of Osteoarthritis Grades On Pain, Function, And Quality Of Life

To investigate the extent to which pain, functionality, and quality of life change over the progression of osteoarthritis grades.

Study Overview

• Status: Completed
• Conditions: Quality of Life; Pain; Osteoarthritis
• Intervention / Treatment: Diagnostic test: Radiographic classification

• Study Type: Observational
• Enrollment (Actual): 161

Contacts and Locations

Study Locations

• Turkey
  • Selçuklu
    • Konya, Selçuklu, Turkey, 42130
      • Selcuk University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

diagnosed with the same grade of knee OA in both knees by the responsible physician in the hospital

Description

Inclusion Criteria:

• having the same OA grade in both knees
• volunteering to participate in the study
• not having undergone previous lower extremity surgery

Exclusion Criteria:

• neurological disorders;
• those with a history of surgery related to the lower extremities;
• those with orthopedic problems in the lower extremities, such as tendinopathy and bursitis;
• those who had neurological, orthopedic, or cognitive disorders that would prevent walking;
• those with a diagnosis of diabetes, obesity, or rheumatological disorders;
• those who had received intra-articular injection therapy within the last three months;
• and those with malignancy or perception problems.

Study Plan

How is the study designed?

Number of groups / cohorts

4

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Grade 1 osteoarthritis; disease stages 1 according to the Kellgren-Lawrence radiographic classification system	Diagnostic test: Radiographic classification; disease stages ranged from 1 to 4 according to the Kellgren-Lawrence radiographic classification system
Grade 2 osteoarthritis; disease stages 2 according to the Kellgren-Lawrence radiographic classification system	Diagnostic test: Radiographic classification; disease stages ranged from 1 to 4 according to the Kellgren-Lawrence radiographic classification system
Grade 3 osteoarthritis; disease stages 3 according to the Kellgren-Lawrence radiographic classification system	Diagnostic test: Radiographic classification; disease stages ranged from 1 to 4 according to the Kellgren-Lawrence radiographic classification system
Grade 4 osteoarthritis; disease stages 4 according to the Kellgren-Lawrence radiographic classification system	Diagnostic test: Radiographic classification; disease stages ranged from 1 to 4 according to the Kellgren-Lawrence radiographic classification system

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Visual Analog Scale (VAS)	a 10-cm straight line with 0 on one end indicating no pain and 10 on the other end signifying unbearable pain. The participants were asked to mark the intensity of their current pain on the line	2 minutes
two-minute walk test (2MWT)	A 45-meter corridor was used for the 2MWT. The start and end points were marked, and the participants were asked to walk at a normal pace within these boundaries. The distance covered in two minutes was recorded	2 minutes
Western Ontario and McMaster Universities Osteoarthritis Index	The questionnaire consists of 24 items, each scored from 0 to 4. The total score is obtained by summing the point equivalents of the responses given to all items. A higher score indicates poorer functionality	10 minutes
Nottingham Health Profile (NHP)	This tool comprises 38 questions in six domains, namely energy, pain, social isolation, physical mobility, emotional reactions, and sleep. Each domain is scored from 0 to 100. The total score is obtained by summing the scores obtained from the six domains. High scores indicate a good quality of life.	10 minutes

Collaborators and Investigators

• Sponsor: Selcuk University

Study record dates

Study Major Dates

• Study Start (Actual): November 1, 2022
• Primary Completion (Actual): May 1, 2023
• Study Completion (Actual): July 1, 2023

Study Registration Dates

• First Submitted: August 21, 2023
• First Submitted That Met QC Criteria: August 23, 2023
• First Posted (Actual): August 29, 2023

Study Record Updates

• Last Update Posted (Actual): August 29, 2023
• Last Update Submitted That Met QC Criteria: August 23, 2023
• Last Verified: August 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Arthritis; Osteoarthritis
• Other Study ID Numbers: 2023/11-21

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No