Effect of Strength Versus Endurance Training on Muscle Damage in Gym Athletes on Caffeine Supplementation.

Dietary supplements to enhance exercise and athletic performance come in a variety of forms, including tablets, capsules, liquids, powders, and bars. Many of these products contain numerous ingredients in varied combinations and amounts. Among the more common ingredients are amino acids, protein, creatine, and caffeine

Study Overview

• Status: Completed
• Conditions: Muscle Damage
• Intervention / Treatment: Other: Strength Training with Caffeine; Other: Endurance Training with Caffeine

Detailed Description

Caffeine is a popular nutritional supplement among gym athletes. It is frequently used as an ergogenic aid to improve physical performance, delay fatigue, and increase muscle power. This research aims to evaluate the effectiveness of caffeine through the blood sample test (Serum CK, LDH levels, AST levels) on muscle damage of gym athletes who are performing aerobic and strength training. This study would help understand the effects of strength training and endurance training on muscle damage in gym athletes who are consuming caffeine and to check the serum enzymes level of both groups who are on strength training and those who are on endurance level training, therefore, this study would help determine which athletes should be careful while consuming caffeine for a particular exercise regimen

• Study Type: Interventional
• Enrollment (Actual): 14
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Pakistan
  • Islamabad Capital Territory
    • Islamabad, Islamabad Capital Territory, Pakistan, 44000
      • Riphah International University (RIU)

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Male gym athletes
• Age: 18-40 years
• Athletes with at least three days training session per week

Exclusion Criteria:

• Athletes already on caffeine supplementation
• Athletes with above normal serum enzyme levels

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Strength Training; Strength training exercises along with caffeine supplementation	Other: Strength Training with Caffeine; The intervention protocol consists of 5 types of strength training exercises. The following exercises will be performed for the strength training group: bench press (3 sets of 10 reps); biceps curl (3 sets of 10 reps); triceps pushdown (3 sets of 10 reps); leg press (3 sets of 10 reps); leg extension (3 sets of 10 reps) Strength training would be performed in 3 sets of 10 repetitions with 2 minutes of rest between each exercise. This protocol will be performed in a 30-40-minute session. 10-15 minutes of light warm-up activities will be performed before the start of each exercise session. The intervention sessions would be carried out with a 3-5-day gap between the two intervention sessions.
Active Comparator: Endurance Training; Endurance training exercises along with caffeine supplementation	Other: Endurance Training with Caffeine; The intervention protocol consists of 3 types of endurance training exercises. The following exercises will be performed by this group: Cycling (15 min); Running (20 min); Rowing (10 min) The intervention sessions would be carried out with a 3-5-day gap between the two intervention sessions.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Serum CK Levels	Serum CK level is the amount of an enzyme called creatine kinase (CK) in the blood. CK is a type of protein present in the muscle cells in human body need which is essential for proper functioning. Levels of CK can rise after a heart attack, skeletal muscle injury, or strenuous exercise	Pre-intervention, after 24 hours of the intervention, after 3 days before second intervention, and after 24 hours of the second intervention
Serum LDH levels	Lactate Dehydrogenase (LDH) is enzyme found in almost every cell of the human body, including your blood, muscles, brain, kidneys, and pancreas.	Pre-intervention, after 24 hours of the intervention, after 3 days before second intervention, and after 24 hours of the second intervention
Serum AST levels	Aspartate aminotransferase (AST) are enzymes found mainly in the liver, but also found in red blood cells, heart cells, muscle tissue and other organs, such as the pancreas and kidneys.	Pre-intervention, after 24 hours of the intervention, after 3 days before second intervention, and after 24 hours of the second intervention

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Rating of fatigue scale/Numeric Rating Scale-Fatigue	This rating-of-fatigue (ROF) scale has been developed which can track the intensity of perceived fatigue in a variety of contexts.	Pre-intervention, after 24 hours of the intervention, after 3 days before second intervention, and after 24 hours of the second intervention

Collaborators and Investigators

• Sponsor: Riphah International University
• Investigators: Principal Investigator: Noman Sadiq, MS-SPT, Riphah International University, Islamabad.

Study record dates

Study Major Dates

• Study Start (Actual): January 12, 2022
• Primary Completion (Actual): November 30, 2022
• Study Completion (Actual): January 31, 2023

Study Registration Dates

• First Submitted: October 11, 2023
• First Submitted That Met QC Criteria: October 11, 2023
• First Posted (Actual): October 17, 2023

Study Record Updates

• Last Update Posted (Estimated): November 13, 2023
• Last Update Submitted That Met QC Criteria: November 9, 2023
• Last Verified: November 1, 2023

More Information

Terms related to this study

• Keywords: Caffeine; Strength Training; Skeletal Muscle; Creatine Kinase; Endurance Training; Fitness Centers
• Additional Relevant MeSH Terms: Physiological Effects of Drugs; Neurotransmitter Agents; Molecular Mechanisms of Pharmacological Action; Enzyme Inhibitors; Purinergic Antagonists; Purinergic Agents; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Central Nervous System Stimulants; Caffeine
• Other Study ID Numbers: REC/01241 Mian Waleed Ahmed

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No