Effect of Mulligans Mobilization With Movement in Osteoarthritis Knee.

Effect of Mulligan's Mobilization With Movement Added With Isometric Exercises on Muscle Strength Pain and Disability Associated With Knee Osteoarthritis: A Randomized Controlled Study

To evaluate the effect of Mulligan's mobilization with movement in osteoarthritis of the knee.

Study Overview

• Status: Completed
• Conditions: Osteo Arthritis Knee
• Intervention / Treatment: Behavioral: Mulligan's mobilization with movement MWM added isometric strength training

Detailed Description

Patients with knee OA diagnosed at the orthopaedic clinic of Tumair general hospital and referred to the physiotherapy department who attended the rehabilitation centre of Majmaah university will be recruited.

Patients will be excluded if they have had a knee or hip injury, sensory deficits in the lower extremity, a history of lower-extremity surgery, a history of a quadriceps or hamstring muscle injury, low back-related leg pain, or any contraindication to manual therapy.

The protocol was submitted to and approved by the Rehabilitation Research Chair, King Saud University Research Ethics Committee (RRC-2021-17)

Participants will be requested to sign a written informed consent form approved by the institutional ethics committee. A total of 60 participants were randomly assigned to group A (experimental group): Mulligan's mobilization with movement MWM added isometric strength training, and group B (control group): Sham MWM added isometric strength training. Pre and post-test readings were taken at baseline, week 2, and week 4, respectively. The outcome measures for this study will be maximal voluntary isometric contraction of quadriceps strength (measured by ISOMOVE dynamometer), ROM, and Western Ontario and McMaster universities osteoarthritis (WOMAC) index.

• Study Type: Interventional
• Enrollment (Actual): 50
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Saudi Arabia
  • Riyadh Region
    • Al Majma'ah, Riyadh Region, Saudi Arabia, 15341
      • Rehabilitation center, Majmaah University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 36 years to 61 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Patient with knee OA with radiological evidence of grade 2 or 3 of the Kellgren and Lawrence scale.
• Age between 40-65 years, unilateral or bilateral involvement (in the case of bilateral involvement, the more symptomatic knee was included), and pain in and around the knee.

Exclusion Criteria:

• Patient will be excluded, if they had any deformity of the knee, hip, or back, had any central or peripheral nervous system involvement.
• They had received steroids or intra-articular injection within the previous three months, uncooperative patients.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Experimental Group; Mulligan's mobilization with movement added isometric strength training will be given 3 days a week for six weeks.	Behavioral: Mulligan's mobilization with movement MWM added isometric strength training; Mulligan's mobilization with movement added isometric exercise: the participants in the experimental group will receive a Mulligan's mobilization with movement added isometric exercise. Treatment will be given for the period of three weeks, for five days a week in both groups. Data will be collected before intervention and after 2nd & 4th week of intervention.; Other Names: Sham MWM added isometric strength training
Active Comparator: Control Group; Mobilization-added isometric strength training will be given 3 days a week for six weeks.	Behavioral: Mulligan's mobilization with movement MWM added isometric strength training; Mulligan's mobilization with movement added isometric exercise: the participants in the experimental group will receive a Mulligan's mobilization with movement added isometric exercise. Treatment will be given for the period of three weeks, for five days a week in both groups. Data will be collected before intervention and after 2nd & 4th week of intervention.; Other Names: Sham MWM added isometric strength training

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
pain intensity	Visual Analogue scale on 0 to10 cm	6 weeks
Range of Motion	Standard goniometer.	6 weeks
Western Ontario and McMaster universities osteoarthritis (WOMAC) index	Western Ontario and McMaster universities osteoarthritis scale	6 weeks

Collaborators and Investigators

• Sponsor: Majmaah University
• Collaborators: King Saud University
• Investigators: Principal Investigator: Shahnaz Hasan, PhD, Majmah University

Study record dates

Study Major Dates

• Study Start (Actual): November 5, 2022
• Primary Completion (Actual): November 10, 2023
• Study Completion (Actual): November 14, 2023

Study Registration Dates

• First Submitted: December 7, 2021
• First Submitted That Met QC Criteria: October 10, 2022
• First Posted (Actual): October 13, 2022

Study Record Updates

• Last Update Posted (Estimated): September 18, 2025
• Last Update Submitted That Met QC Criteria: September 14, 2025
• Last Verified: November 1, 2023

More Information

Terms related to this study

• Keywords: Rehabilitation; Osteoarthritis; Isometric exercise
• Additional Relevant MeSH Terms: Musculoskeletal Diseases; Arthritis; Joint Diseases; Rheumatic Diseases; Osteoarthritis
• Other Study ID Numbers: RRC-2021-17

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: Data will be kept secure with the principal investigator (Dr. Shahnaz Hasan) and sub-investigator (Dr. Naiyer Shahzad) due to confidentiality issues.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No