The Energize! Study for Adults With Knee Replacement

Energize! Internet-Delivered Physical Activity Program for Adults With Knee Replacement

The purpose is to examine the effects of an online physical activity program on moderate to vigorous intensity physical activity, pain, and physical function in adults with knee replacement at 3 months (post-intervention) and 6 months (maintenance).

Study Overview

• Status: Completed
• Conditions: Knee Arthroplasty
• Intervention / Treatment: Behavioral: Energize!

Detailed Description

Participants with knee replacement will be randomized to start the online physical activity program (Energize!) either immediately or after 3 months. The online program consists of weekly physical activity goals, video lessons, action planning, and homework to help increase physical activity to 200 min/week. Assessments will be completed at baseline, 3 months, and 6 months.

• Study Type: Interventional
• Enrollment (Actual): 50
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • South Carolina
    • Columbia, South Carolina, United States, 29208
      • University of South Carolina

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Have had a partial or total knee replacement ≥12 months ago
• Have regular access to the internet
• Willing to wear activity monitor for 7 days at baseline, 3 & 6 months
• Engage in less than 60 minutes of self-reported moderate intensity exercise

Exclusion Criteria:

• Have a mobility limiting comorbidity
• Non-English speaking
• Have a scheduled surgery within the next 6 months that would limit activity

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Energize!; Participants randomized to Energize! will start the program immediately after baseline.	Behavioral: Energize!; Energize! is 3 month online physical activity program which consists of weekly physical activity goals, video lessons, action planning, and homework.
Other: Delayed Energize!; Participants randomized to Delayed Energize! will start the program after the 3 month assessment.	Behavioral: Energize!; Energize! is 3 month online physical activity program which consists of weekly physical activity goals, video lessons, action planning, and homework.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Minutes of Moderate to Vigorous Intensity Physical Activity	Minutes of moderate to vigorous intensity physical activity assessed by Actigraph accelerometers	baseline to 3 months
Pain Intensity	Pain intensity assessed by Patient-Reported Outcomes Measurement Information System pain intensity survey. 0 represents no pain and 10 reports the most severe pain	baseline to 3 months
Self-reported Physical Function	Physical function assessed by Patient-Reported Outcomes Measurement Information System (PROMIS) physical function/mobility survey. A t-score of 0 represents poor function compared to average and 100 represents better function. A t-score of 50 indicates the population mean with a standard deviation of 10.	baseline to 3 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Minutes/Week of Moderate to Vigorous Intensity Physical Activity	Minutes of moderate to vigorous intensity physical activity assessed by Actigraph accelerometers worn on the waist for 7 days	3 months to 6 months
Pain Intensity	Pain intensity assessed by Patient-Reported Outcomes Measurement Information System pain intensity survey. 0 represents no pain and 10 reports the most severe pain	3 months to 6 months
Self-reported Physical Function	Physical function assessed by Patient-Reported Outcomes Measurement Information System (PROMIS) physical function/mobility survey. A t-score of 0 represents poor function compared to average and 100 represents better function. A t-score of 50 indicates the population mean with a standard deviation of 10.	3 months to 6 months

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Adherence to Energize Program - Video Lessons Viewed	Number of video lessons viewed	3 months
Adherence to Energize Program - Planning or Reporting Exercise Minutes	Number of weeks exercise minutes were planned or reported	3 months
Adherence to Energize Program - Homework Assignments	Number of homework assignments completed	3 months

Collaborators and Investigators

• Sponsor: University of South Carolina

Study record dates

Study Major Dates

• Study Start (Actual): October 24, 2023
• Primary Completion (Actual): September 10, 2024
• Study Completion (Actual): September 10, 2024

Study Registration Dates

• First Submitted: October 17, 2023
• First Submitted That Met QC Criteria: October 17, 2023
• First Posted (Actual): October 24, 2023

Study Record Updates

• Last Update Posted (Actual): March 27, 2026
• Last Update Submitted That Met QC Criteria: March 6, 2026
• Last Verified: March 1, 2026

More Information

Terms related to this study

• Keywords: physical activity
• Additional Relevant MeSH Terms: Behavior; Motor Activity
• Other Study ID Numbers: Pro00130186

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: As this is a pilot study, we do not have a plan to share IPD.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No