Study of Visceral Fat in type2diabetic Patients and Its Relation to Microvascular Complications

Study of Visceral Fat in Type 2diabetic Patients and Its Relation to Microvascular Complications

Study the correlation between METS IR and visceral fat in type 2 diabetes and its relation to microvascular complication

Study Overview

• Status: Enrolling by invitation
• Conditions: Insulin Resistance; Visceral Fat

Detailed Description

The Metabolic Score for Insulin Resistance (METS-IR) is a metabolic index developed with the aim to quantify peripheral insulin sensitivity in humans; it was first described under the name METS-IR by Bello-Chavolla et al in 2018. It was developed by the Metabolic Research Disease Unit at the Institute National de Ciencias Médicas Salvador Zubirán and validated against the euglycemic hyperinsulinemic clamp and the frequently-sampled intravenous glucose tolerance test in Mexican population.It is a non-insulin-based alternative to insulin-based methods to quantify peripheral insulin sensitivity and an alternative to the Homeostatic Model Assessment (HOMA-IR) and the quantitative insulin sensitivity check index (QUICKI).

Very limited research correlate between visceral obesity and microvascular complications in type 2 diabetic patients and how can the metabolic score for insulin resistance predict visceral obesity and microvascular complications in type2 diabetic patients. In this study the investigators will search for these correlations.

• Study Type: Observational
• Enrollment (Estimated): 100

Contacts and Locations

Study Locations

• Egypt
  • Sohag, Egypt, 00000
    • Mahmoud Soliman

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Probability Sample

Study Population

Patients of T2DM, either newly diagnosed or previously diagnosed and on treatment with antidiabetic oral hypoglycemic agents or insulin and attending diabetes OPD or admitted to the Medicine Department, were taken as cases. Age- and gender-matched nondiabetic people admitted to the Medicine Department were taken as control subjects. Both these groups will be interviewed, examined, investigated, and included in the study.

Description

Inclusion Criteria:

• Age > 18 years Both male and female subjects Subjects capable of giving consent and voluntarily willing to participate in the study

Exclusion Criteria:

• Chronic kidney disease patients Any nondiabetic nephropathy patients Patients affected by hypertension Patients affected by ocular disorders Neuropathies of other etiologies like chronic liver disease patients, alcoholics, or drug addicts Critically ill patients of type 2 diabetes mellitus Patients who have not given consent

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
correlation between METS IR and visceral fat in type 2 diabetes	Study the cor relation between METS IR and visceral fat in type 2 diabetes and its relation to microvascular complication	one year

Collaborators and Investigators

• Sponsor: Sohag University
• Investigators: Study Director: mahmoud soliman, Sohag University

Study record dates

Study Major Dates

• Study Start (Estimated): January 5, 2024
• Primary Completion (Estimated): January 5, 2025
• Study Completion (Estimated): June 5, 2025

Study Registration Dates

• First Submitted: October 26, 2023
• First Submitted That Met QC Criteria: October 26, 2023
• First Posted (Actual): November 1, 2023

Study Record Updates

• Last Update Posted (Actual): November 2, 2023
• Last Update Submitted That Met QC Criteria: October 31, 2023
• Last Verified: October 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Glucose Metabolism Disorders; Metabolic Diseases; Hyperinsulinism; Insulin Resistance
• Other Study ID Numbers: Soh-Med-23-10-13MD

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No