Glycolic Acid Plus Salicylic Acid in Treatment of Plane Wart

January 22, 2024 updated by: Doaa Abo Elmagd Abd El Razak, Assiut University

Efficacy of Glycolic Acid 15%Plus Salicylic Acid 2% Gel in Treatment of Plane Wart

To determine clinical efficacy of glycolic acid 15%plus salicylic acid 2% gel in treatment of Plane wart .

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Warts are typically small, rough, hard growths that are similar in color to the rest of the skin. They typically asymptomatic , except when on the bottom of the feet, where they may be painful While they usually occur on the hands and feet, they can also affect other locations One or many warts may appear They are not cancerous .

Warts are caused by infection with human papillomavirus(HPV). Factors that increase the risk include use of public showers, working with meat, eczema and a weak immune system. The virus is believed to enter the body through skin that has been damaged slightly.

Warts are classified to common wart, plane wart, plantar wart, genital wart. Plane warts are circumscribed papules with hyperkeratotic surfaces that can occur singly or in groups. In these types of warts, the human papilloma virus (HPV) has been shown to infect the keratinocyte. Although no viral subtype is absolute, typically the infection is with HPV types 3, 10, 28, and 41 These warts are small in size (1-5mm), flat, or slightly elevated lesions. Plane viral warts typically present as skin-colored or light brownish,papules on the face, beard area, or on the back of the hands, and primarily affect children.

Plane warts can greatly affect a patient's quality of life, and their persistence or recurrence cause frustration.

Their evolution is variable, and although two thirds of cases regress spontaneously in the course of two years due to immunological mechanism

The following therapies have been used in the treatment of Plane wart with varying success: salicylic acid, cryotherapy, retinoic acid, photodynamic therapy (topical 5-aminolevulinic acid photodynamic therapy), pulsed dye laser (PDL), and Candida antigen.

New medication is a combination of glycolic acid 15% plus salicylic acid 2% gel.

Glycolic acid has been used in the treatment of Plane wart . It has been suggested that alpha-hydroxy acids can produce an authentic exfoliation and dehiscence of the coenocytes from recently formed layers of the stratum corneum. Alpha-hydroxy acids also reduce the number of desmosomes and tonofilaments.in this study all patients will be instructed to avoid sun exposure during the treatment and to use broad spectrum sunscreen The treatment was started once daily over the entire face and maintained for two months. A fine layer of face gel was applied on the whole surface where the warts were present, avoiding the eyelids and lips. In children 7 to 10 years of age, face gel was applied by their parents. Clinical controls were performed at Weeks 2, 4, 6, and 8.

Study Type

Interventional

Enrollment (Actual)

100

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
      • Assiut, Egypt, 02 35315900
        • Assiut University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child

Accepts Healthy Volunteers

No

Description

Inclusion criteria Site: face

Exclusion criteria :

  1. Photosensitivity
  2. Scaring keloid
  3. Herpes simplex
  4. Pregnancy & Lactation

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Other: efficacy of glycolic acid 15%plus salicylic acid 2% gel in treatment of Plane wart .
Other: Glycolic Acid Plus Salicylic Acid in Treatment of Plane Wart
Prior to the procedure, patients will be instructed to avoid sun exposure during the treatment and to use broad spectrum sunscreen The treatment was started once daily over the entire face and maintained for two months. A fine layer of Glycolic Acid Plus Salicylic Acid face gel was applied on the whole surface where the warts were present, avoiding the eyelids and lips. In children 7 to 10 years of age, face gel was applied by their parents. Clinical controls were performed at Weeks 2, 4, 6, and 8.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
treatment of plane wart
Time Frame: 8weeks

Evaluation of the efficacy of topical glycolic acid plus salicylic acid in treatment of plane wart.

Response to treatment will be evaluated by the decrease in number or size of plane wart.
8weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Assiut University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 1, 2021

Primary Completion (Actual)

September 30, 2022

Study Completion (Actual)

December 30, 2022

Study Registration Dates

First Submitted

November 21, 2023

First Submitted That Met QC Criteria

January 22, 2024

First Posted (Estimated)

January 31, 2024

Study Record Updates

Last Update Posted (Estimated)

January 31, 2024

Last Update Submitted That Met QC Criteria

January 22, 2024

Last Verified

November 1, 2023

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • glycolicandsalicylicacidinwart

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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