- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05652998
Comparison Between Intralesional Injection of Plasma Rich Platelets and Candida Antigen in Plane Warts
Comparative Study Between Intralesional Injection of Autologous Plasma Rich Platelets Versus Candida Antigen in Patients With Plane Warts
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Cutaneous warts are benign tumors caused by infection of keratinocytes by different serotypes of human papillomavirus(HPV). Its incidence increases during the school years to reach a peak in adolescence and early adulthood, then declines rapidly through the twenties and more gradually thereafter.
Plane warts are mainly caused by HPV serotypes 3, 10, 28, and 41, presenting mainly in children and young adults. They present as skin colored or may be hyperpigmented smooth-surfaced, slightly elevated or flat-topped papules. They are polygonal or round in shape and range in sizes from 1 to 5 mm. The main sites of predilection for the plane warts are the face, dorsal aspects of the hands and forearms, often in a linear array.
Platelet rich plasma (PRP) is an autologous blood-derived product enriched in platelets. Platelets, also called thrombocytes, are blood cells that cause blood clots and other necessary growth healing functions. PRP represents a new bio technology that is part of the growing interest in tissue engineering and cellular therapy today. While it is of autologous origin, it reduces the possibility of adverse effects and transfusion-transmitted infections, so it is well-tolerated therapy for the patients. PRP has been used in the treatment of many cutaneous diseases such as alopecia and acne vulgaris. Its utility has been extended to other cutaneous diseases as melasma, hyperpigmentation, and burns, wherever it elicits tissue repair and regeneration.
Intralesional immunotherapy depends on the ability of the immune system to recognize certain viral, bacterial, and fungal antigens, such as Candida or Trichophyton antigens that induce a delayed-type hypersensitivity reaction, not only to the antigen but also against the wart virus, which in turn increases the ability of the immune system to recognize and eradicate HPV. This stimulated immune response could then subsequently destroy all the injected and noninjected lesions on the body, rather than the locally treated lesion.
Intralesional antigen immunotherapy has recently received increased attention and is considered by many authors a promising modality for the treatment of different types of warts, including the recurrent and recalcitrant variants.
Study Type
Enrollment (Anticipated)
Phase
- Phase 4
Contacts and Locations
Study Locations
-
-
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Qinā, Egypt
- South Valley University
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Patients proved as having clinically evident plane warts.
- Patients with both sexes with no age limits.
Exclusion Criteria:
- Patient receiving immune suppressive drugs.
- Patients with major comorbidities or concomitant malignancies.
- Patients with any evidence of immunosuppression including HIV infection.
- Patients with any eczematous skin disorder
- Those with any history of hypersensitivity to Candida albicans antigen.
- Patients with chronic systemic medical diseases and bleeding disorders .
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Candida antigen
patients will be injected with intralesional C.albicans antigen
|
a test dose (0.1 ml) of the C. albicans antigen will be injected intradermally into the skin of the forearm.
A reaction will be considered positive in presence of ≥5 mm erythema and induration after 48-72 hr.
Only reactors will be included.
patients will receive intralesional injection of candida antigen at a dose 0.1 ml of 1/1000 solution into the largest wart at 3 weekly intervals for a total of 3 doses.
|
Active Comparator: Autologous platelets rich plasma
patients will receive intralesional autologous PRP injection
|
patients will receive intralesional autologous PRP injection every month until a complete clearance or for a maximum of 2 sessions.
20 cc blood will be collected under a complete aseptic condition in citrate tubes .
The lower 2-4 cc of the plasma will be provided as PRP concentrate after centrifugation.
0.1 ml of PRP will be injected intralesional with an insulin syringe.
|
Placebo Comparator: Saline
patients will receive intralesional saline
|
patients will receive intralesional saline at a dose of 0.3ml into the largest wart at 2-week intervals until complete clearance is achieved or for a maximum of five treatment
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Treatment of plane wart
Time Frame: 6 months
|
Evaluation of the efficacy of intradermal injection of candida albicans antigen versus autologous platelet rich plasma in treatment of plane warts
|
6 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Treatment of plane wart
Time Frame: 6 Months
|
Response to treatment will be evaluated by the decrease in size of warts.
Lesions with size decrease of less than 50% will be defined as no therapeutic response, size decrease between 50 and 99% as relative response, and complete removal of the lesions will be considered as complete cure.
|
6 Months
|
Collaborators and Investigators
Investigators
- Study Director: Hassan M Ibrahim, Ass. Prof., Faculty of Medicine - South Valley University
- Study Director: Mohamed A Ali, Prof. Dr., faculty of medicine - Sohag university
- Study Director: Eisa M Hegazy, Ass. Prof., Faculty of Medicine - South Valley University
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 233/9/21
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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