Autonomic and Metabolic Response to Cardiac Rehabilitation After Acute MI (RIABILITOMICA)

August 19, 2025 updated by: Istituto Auxologico Italiano

Autonomic and Metabolic Response to Cardiac Rehabilitation After Acute Myocardial Infarction

Ischemic heart disease remains the leading cause of death in the western world. The beneficial effects of cardiac rehabilitation on the evolution of ischemic heart disease are known, but the effects of rehabilitation on the metabolic processes of the patients are so far poorly understood. Metabolomics is the qualitative/quantitative analysis of the body's metabolic responses to pathophysiological stimuli or genetic alterations. Metabolic changes caused by physical activity have been demonstrated in obese and diabetic patients and in athletes. Aim of the study is to evaluate whether cardiac rehabilitation after a first myocardial infarction induces changes in the metabolic state of patients, and whether these changes may be related with changes in the usual risk factors (i.e. glyco-lipidic profile, natriuretic peptides, homocysteine).

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

25

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Italy
      • Milan, Italy, 20149
        • Istituto Auxologico Italiano

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

All consecutive patients meeting the eligibility criteria will be proposed to participate in the study

Description

Inclusion Criteria:

  • recent first acute myocardial infarction

Exclusion Criteria:

  • severe diabetes

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Patient after first acute myocardial infarction
Other: Cardiac rehabilitation
Six weeks of cardiac rehabilitation with physical training

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Changes in purine after rehabilitation
Time Frame: Baseline and after 6 weeks of rehabilitation
The concentration of purine will be calculated after rehabilitation, and compared to its baseline concentration by a paired T test analysis.
Baseline and after 6 weeks of rehabilitation
Changes in histidine after rehabilitation
Time Frame: Baseline and after 6 weeks of rehabilitation
The concentration of purine will be calculated after rehabilitation, and compared to its baseline concentration by a paired T test analysis
Baseline and after 6 weeks of rehabilitation
Changes in galactose after rehabilitation
Time Frame: Baseline and after 6 weeks of rehabilitation
The concentration of galactose will be calculated after rehabilitation, and compared to its baseline concentration by a paired T test analysis.
Baseline and after 6 weeks of rehabilitation

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Istituto Auxologico Italiano

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 2, 2023

Primary Completion (Actual)

June 12, 2024

Study Completion (Actual)

January 13, 2025

Study Registration Dates

First Submitted

March 1, 2024

First Submitted That Met QC Criteria

March 1, 2024

First Posted (Actual)

March 7, 2024

Study Record Updates

Last Update Posted (Actual)

August 21, 2025

Last Update Submitted That Met QC Criteria

August 19, 2025

Last Verified

August 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 09C338

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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