Calcified Cerebral Embolism: a Descriptive Study in a Large Single Center Cohort (CCE Cohorte)

January 21, 2026 updated by: Centre Hospitalier Universitaire de Nīmes
Calcified cerebral embolism (CCE) is a relatively rare but underdiagnosed cause of infarction. CCE diagnosis is made by CT. Radiological characteristics of CCE have been reported in small case series. The aim of this study was to describe clinical and radiological characteristics of CCE in a large number of patients, and to compare patients with different radiological CCE characteristics.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

79

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Nîmes, France, 30029
        • CHU de Nîmes

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Probability Sample

Study Population

Patients with CEE treated with intravenous thrombolysis (IVT) between 2015 and 2020, and patients with AIT/stroke with a CCE identified on CT between deceber 2019 and april 2023.

Description

Inclusion Criteria:

  • Patients with CEE treated with intravenous thrombolysis (IVT) between 2015 and 2020 managed at the CHU de Nîmes or Patients with TIA/stroke with ECC identified on CT between 12/2019 and 04/2023 managed at CHU de Nîmes

Exclusion Criteria:

  • Patient's refusal to use his/her data

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Patients with CCE
CCE patients identified between 2015 and 2023
Other: None, purely observational study
None, purely observational study

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Calcified aortic brachiocephalic
Time Frame: baseline
looking for calcified aortic brachiocephalic (presence or absence)
baseline
cardiovascular risk
Time Frame: baseline
Study of cardiovascular risk factors (presence or absence)
baseline
history of stroke
Time Frame: baseline
Presence of a history of stroke (y/n)
baseline
Population
Time Frame: baseline
demographic characteristics age (years)
baseline
Population
Time Frame: baseline
demographic characteristics sexe (M/F)
baseline
history of surgical/endovascular cardiovascular intervention
Time Frame: baseline
surgical/endovascular cardiovascular intervention (y/n)
baseline
NIHSS
Time Frame: baseline
NIHSS score (Score between 1 and 4: minor stroke, Score between 5 and 15: moderate, stroke, Score between 15 and 20: severe stroke) Score > 20: severe stroke
baseline
calcified aortic arch
Time Frame: baseline
looking for calcified aortic arch (presence/absence)
baseline
calcified carotid
Time Frame: baseline
looking for calcified carotid (presence/absence)
baseline
atherosclerotic plaques
Time Frame: baseline
looking for atherosclerotic plaques (presence/absence)
baseline
calcified aortic valves
Time Frame: baseline
looking for calcified aortic valves (presence/absence)
baseline
calcified mitral valves
Time Frame: baseline
looking for calcified mitral valves (presence/absence)
baseline
CCE diameter
Time Frame: baseline
CCE diameter measurement (mm)
baseline
density
Time Frame: baseline
CCE density (uh)
baseline
involved cerebral artery
Time Frame: baseline
description of involved cerebral artery
baseline

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Centre Hospitalier Universitaire de Nīmes

Investigators

  • Study Director: Anissa MEGZARI, Centre Hospitalier Universitaire de Nîmes

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 16, 2024

Primary Completion (Actual)

November 30, 2024

Study Completion (Actual)

November 30, 2024

Study Registration Dates

First Submitted

February 26, 2024

First Submitted That Met QC Criteria

March 6, 2024

First Posted (Actual)

March 13, 2024

Study Record Updates

Last Update Posted (Actual)

January 23, 2026

Last Update Submitted That Met QC Criteria

January 21, 2026

Last Verified

December 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • LOCAL/2024/TP-01
  • IRB 24.01.01 (Other Identifier: IRB)

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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