Physical Activity in Children With Wolff-Parkinson-White Syndrome

Physical Activity Level and Determinants in Children With Wolff-Parkinson-White Syndrome

The aim of this study was to investigate the level of physical activity and its determinants in children with WPW.

Study Overview

• Status: Completed
• Conditions: Wolff-Parkinson-White Syndrome
• Intervention / Treatment: Other: Cardiopulmonary exercise test; Other: Atrial-Ventricular Strain Analysis; Other: Arterial Stiffness Measurement; Other: Physical Activity Level; Other: Physical Activity Barriers Assesment

• Study Type: Observational
• Enrollment (Actual): 26

Contacts and Locations

Study Locations

• Turkey
  • Ankara, Turkey
    • Hacettepe University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult
• Accepts Healthy Volunteers: N/A

• Sampling Method: Non-Probability Sample

Study Population

Patients aged 7-18 years who are followed up by the Department of Paediatrics, Division of Paediatric Cardiology, Faculty of Medicine of a university will be included in the study.

Description

Inclusion Criteria:

• Being between 7-18 years old
• Ensuring clinical stability in patients
• No change in drug therapy, if any, that adversely affects clinical stability

Exclusion Criteria:

• Neurological and/or genetic musculoskeletal disorders
• Diagnosed orthopaedic and cognitive problems that prevent the tests from being performed
• History before 4 weeks of cardiac or other body system problems
• The patient and/or his/her family does not want to be included in the study

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Control Group	Other: Physical Activity Level; Physical activity level will be assessed with the Child Physical Activity Questionnaire.; Other: Physical Activity Barriers Assesment; "Physical Activity Outcome Expectancies (child survey)" and "Physical Activity Home Environment Scale (Child)" will be used in children, while " Physical activity barriers (Parent)" will be used in family members.
WPW group	Other: Cardiopulmonary exercise test; The cardiopulmonary exercise test (CPET), the gold standard for the assessment of cardiorespiratory fitness, will be used. The Modified Bruce/half Bruce protocol with will be used. In addition, dyspnoea, leg fatigue and general fatigue will be recorded every three minutes at rest, during the test and during the post-test recovery phases using the Modified Borg Scale and blood pressure will be recorded with a sphygmomanometer. The test will be continued until individuals reach the end of the protocol or until the last point at which they wish to stop the test. The test will be terminated if the patient wishes to terminate the test, severe breathlessness, leg fatigue or general fatigue, loss of coordination, progressive chest pain, ST segment elevation or depression of more than 2 mm, oxygen saturation of 80% or less, reaching 85% or more of the predicted heart rate. Oxygen consumption (VO2peak) will be used as the primary outcome measure for cardiorespiratory fitness.; Other: Atrial-Ventricular Strain Analysis; Atrial-Ventricular strain will be evaluated by a specialist physician using Speckle Tracking Echocardiography. During the evaluation, standard echocardiographic measurements will be made with transthoracic echocardiography. With these measurements, images suitable for strain analysis will be obtained. Deformation analysis will be performed using the speckle tracing method for the appropriate images obtained and hemodynamic parameters obtained by the analysis will be recorded.; Other: Arterial Stiffness Measurement; Arterial stiffness will be assessed using the pulse wave velocity (PWV) technique with the Mobile-O-GRAPH (TG) (LE.M., Stolberg, Germany), an oscillometer-based device. After the patients have rested sufficiently, measurements will be taken in an upright sitting position in a quiet and sufficiently bright environment at room temperature, with the device manso placed 2-3 cm above the chiibital fossa in the non-dominant upper limb and the arms raised to the level of the heart. Pulse propagation velocity will be calculated in m/sec with the help of a computer. A high velocity data indicates a high level of arterial stiffening and a low velocity data indicates a low level of arterial stiffening.; Other: Physical Activity Level; Physical activity level will be assessed with the Child Physical Activity Questionnaire.; Other: Physical Activity Barriers Assesment; "Physical Activity Outcome Expectancies (child survey)" and "Physical Activity Home Environment Scale (Child)" will be used in children, while " Physical activity barriers (Parent)" will be used in family members.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The Physical Activity Questionnaire for Older Children Score	The PAQ-C comprises ten items and higher scores indicate a higher level of activity. The first item of the PAQ-C consists of 22 common sports and leisure activities for which the participants select the score based on the frequency of the activity performed during the preceding seven days on a five-point rating scale, after which a mean composite score was calculated. The remaining eight items address physical activities performed during the day, for example, physical education classes, recess time, lunchtime, as well as afterschool activities on weekday evenings and weekends, and finally a summary for all days of the week. The mean score of the first nine items is the summary score of the PAQ-C. The tenth item inquires about any unusual circumstances (e.g., sickness) that affected/prevented the child's physical activity in the seven days preceding the assessment.	15-20 mins

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
VO2peak	Peak oxygen uptake	30-45 minutes
aPWV	Arterial pulse wave velocity	15-20 minutes
GLS	Global longitudinal strain for LV function	30-45 minutes
LASr	Left atrial strain - Reservuar	30-45 minutes
LASct	Left atrial strain - Contractile	30-45 minutes
LAScd	Left atrial strain - Conduit	30-45 minutes
Physical Activity Outcome Expectancies (Child) scale score	The scale is a three-point Likert-type scale consisting of 17 items and two dimensions. The "Negative outcome expectancies" sub-dimension of the scale consists of items 2, 3, 4, 6, 7, 11, 12, 14 and 16 and the "Positive outcome expectancies" sub-dimension consists of items 1, 5, 8, 9, 10, 13, 15 and 17. Total scores are obtained separately for the two dimensions. The score that can be obtained from the 9 items related to the negative outcome expectancies sub-dimension varies between 9 and 17. The score that can be obtained from 8 items related to the positive outcome expectancy sub-dimension varies between 8 and 24. A high score in the negative outcome expentancies sub-dimension indicates an excess of negative expectations about physical activity. A high score on the Positive Outcome Expentancies sub-dimension indicates an excess of positive expectations about physical activity.	15-20 minutes
Physical Activity Home Environment (Child) scale score	The scale is a triple likert type scale consisting of 5 items. - The score range of the scale is 5-15. - A high score on the scale indicates that the family supports the child to be more physically active.	15-20 minutes
Physical activity barriers (Parent) scale score	The original scale consists of 13 items and two dimensions. The Turkish adapted version of the scale consists of two dimensions and 11 items. Items 1-6 in the scale constitute the "Environmental barriers" sub-dimension and items 7-11 constitute the "Personal barriers" sub-dimension. Total scores are obtained separately for the two sub-dimensions of the scale. The score range varies between 6 (min) and 30 (max) for the "Environmental barriers" sub-dimension and between 5 (min) and 25 (max) for the "Personal barriers" sub-dimension. The higher score in the sub-dimensions indicates the magnitude of the barriers to physical activity in those areas for the participant.	15-20 minutes

Collaborators and Investigators

• Sponsor: Karamanoğlu Mehmetbey University

Study record dates

Study Major Dates

• Study Start (Actual): March 1, 2024
• Primary Completion (Actual): December 1, 2024
• Study Completion (Actual): December 1, 2024

Study Registration Dates

• First Submitted: March 30, 2024
• First Submitted That Met QC Criteria: March 30, 2024
• First Posted (Actual): April 5, 2024

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: January 28, 2025
• Last Verified: January 1, 2025

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Synucleinopathies; Cardiac Conduction System Disease; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Cardiovascular Diseases; Pathologic Processes; Heart Diseases; Disease; Arrhythmias, Cardiac; Neurodegenerative Diseases; Congenital Abnormalities; Cardiovascular Abnormalities; Heart Defects, Congenital; Movement Disorders; Parkinsonian Disorders; Basal Ganglia Diseases; Pre-Excitation Syndromes; Syndrome; Parkinson Disease; Wolff-Parkinson-White Syndrome
• Other Study ID Numbers: PA-WPW

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No