The Impact of Grand Tour Cycling on Sleep and the Hematological and Metabolomic Profile in World-class Cyclists

The Impact of Grand Tour Cyling on Sleep and the Hematological and Metabolomic Profile in World-class Cyclists

This project aims to identify the effect of a 3-week Grand Tour (e.g. Tour de France, Giro d'Italia, and Vuelta a España) on sleep, hematological parameters and the serum metabolome in world-class cyclists.

Study Overview

• Status: Enrolling by invitation
• Conditions: Overreaching
• Intervention / Treatment: Other: Cyclist

• Study Type: Observational
• Enrollment (Estimated): 16

Contacts and Locations

Study Locations

• Belgium
  • Vlaams-Brabant
    • Leuven, Vlaams-Brabant, Belgium, 3000
      • KU Leuven

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: N/A

• Sampling Method: Non-Probability Sample

Study Population

Elite cyclist participating in a Grand Tour (e.g. Tour de France, Vuelta a España, Giro d'Italia)

Description

Inclusion Criteria:

• Cylist participating in a Grand Tour (e.g. Tour de France, Vuelta a España, Giro d'Italia)

Exclusion Criteria:

• /

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort

Intervention / Treatment

Elite cyclists participating in a Grand Tour; Sleep metrics will be tracked by a smart ring (OURA Gen3, OURA Health Ltd, Oulu, Finland) starting from one month prior to the start till the end of the Grand Tour; Nocturnal heart rate and heart rate variability will be collected by a smart ring (OURA Gen3, OURA Health Ltd, Oulu, Finland) starting from one month prior till the end of the Grand Tour; Fasted whole blood samples and urine samples will be collected on the morning of (i) the first stage, (ii) the first restday, (iii) second restday, and (iv) last stage of the GrandTour (only in one Grand Tour for a total of 8 cyclists).

Other: Cyclist; Participating in the Grand Tour as cyclist

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Serum metabolome abundance of cyclists participating in a Grand Tour	Changes in the abundance of serum metabolites within the cyclists between 4 timepoints (measured by mass spectrometry)	Start of the Grand Tour - restday 1 of the Grand Tour - restday 2 of the Grand Tour - last day of the Grand Tour
Sleep efficiency during the Grand Tour	Percentage change in sleep efficiency during the Grand Tour (measured by OURA ring)	Every night starting from one week before till the last night of the Grand Tour
Total sleep time during the Grand Tour	Change in total sleep time during the Grand Tour (measured by OURA ring)	Every night starting from one week before till the last night of the Grand Tour
Blood haemoglobin concentration	Change in the blood haemoglobin concentration during the Grand Tour	Start of the Grand Tour - restday 1 of the Grand Tour - restday 2 of the Grand Tour - last day of the Grand Tour

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Wakefulness after sleep onset	Percentage change in wakefulness after sleep onset during the Grand Tour (measured by OURA ring)	Every night starting from one week before till the last night of the Grand Tour
Light sleep	Percentage change in light sleep during the Grand Tour (measured by OURA ring)	Before the start of the Tour - restday 1 - restday 2 - end of Grand Tour
Deep sleep	Percentage change in deep sleep during the Grand Tour (measured by OURA ring)	Before the start of the Tour - restday 1 - restday 2 - end of Grand Tour
REM sleep	Percentage change in REM sleep during the Grand Tour (measured by OURA ring)	Before the start of the Tour - restday 1 - restday 2 - end of Grand Tour
Red blood cell concentration	Change in red blood cell concentration during the Grand Tour	Start of the Grand Tour - restday 1 of the Grand Tour - restday 2 of the Grand Tour - last day of the Grand Tour
Subjective fatigue	Absolute change in subjective fatigue during the Grand Tour (measured by 11-point scale)	Start of the Grand Tour - restday 1 of the Grand Tour - restday 2 of the Grand Tour - last day of the Grand Tour

Collaborators and Investigators

• Sponsor: KU Leuven

Study record dates

Study Major Dates

• Study Start (Actual): July 1, 2023
• Primary Completion (Estimated): September 15, 2024
• Study Completion (Estimated): December 1, 2024

Study Registration Dates

• First Submitted: April 17, 2024
• First Submitted That Met QC Criteria: April 24, 2024
• First Posted (Actual): April 26, 2024

Study Record Updates

• Last Update Posted (Actual): April 26, 2024
• Last Update Submitted That Met QC Criteria: April 24, 2024
• Last Verified: April 1, 2024

More Information

Terms related to this study

• Keywords: Cycling; Metabolomics; Sleep; Grand Tour
• Other Study ID Numbers: S67595

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No