Effect of Two Physical Training Programs on Oxygen Uptake and Heart Rate On-kinetics in Patients COPD (BVPS-123)

February 6, 2012 updated by: Bruna Varanda Pessoa, Universidade Federal de Sao Carlos

Effect of the Combined (Aerobic/Resisted) and Interval Physical Training on Oxygen Uptake and Heart Rate On-kinetics Responses in Patients With Moderate to Very Severe COPD: Double-blind, Randomized, Controlled Trial

Patients with chronic obstructive pulmonary disease (COPD) present slowed pulmonary oxygen uptake (VO2) and heart rate (HR) kinetics compared with age-matched controls. Patients with COPD present significant loss of body mass, decreased strength and endurance of respiratory muscles and lower limbs, leading reduced exercise capacity. This reduced exercise capacity can be marked by slowed kinetics of VO2 and HR at the onset of heavy-intensity exercise. Additionally, derangements in the diffusive and convective transport of oxygen to skeletal muscle mitocondria, and intramyocyte metabolic machinery, higher ventilation and disturbances in mechanics of breathing, hypoxemia, pulmonary hemodynamics, autonomic balance, and peripheral vasodilation, and accumulation of by-products that might be related to increased muscle fatigability could slow the response of systemic (central) and peripheral (microvascular) oxygen delivery to a point where the kinetics of VO2 might become limited by O2 availability and HR. Thus, the physical training programs of the lower limbs, in addition to presenting scientific evidence "A", are important components, resulting in the reversal of the manifestations of COPD, resulting in improvement in exercise capacity, well significantly speeded VO2 and HR kinetics in patients with COPD. However, it should be taken into account the choice of an appropriate program limitations and severity of disease. Assuming that COPD patients present slower VO2 and HR kinetics, the investigators hypothesized that the heavy-intense interval physical training in equipament elliptical would promote a greater increase in the functionality (functional performance) and speeded kinetics in the cycle ergometer and elliptical equipment constant-load intense exercises tests of COPD patients. In this context, the present study intends to evaluate and compare the effects of resistive plus aerobic physical training and interval physical training on oxygen consumption (VO2) and heart rate (HR) kinetics responses at the onset in cycle ergometer and elliptical equipment constant-load intense exercises tests in patients with COPD.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Subjects performed after and before of two physical training program the following tests: lung function test,cardiopulmonary exercise testing (CPT), constant-load exercise test in cycle ergometer, Constant-load exercise test in elliptical equipament, one repetition maximum test(1RM), on alternate days.

  • Lung function: All patients underwent spirometry with the determination of FEV1 and FVC according to American Thoracic Society recommendations. Spirometry was performed using a COSMED microQuark PC - based Spirometer ®, (Pavona di Albano - Roma, Itália), which was calibrated before each test.
  • Cardiopulmonary Exercise Testing (CPT): Incremental symptom-limited exercise testing was performed on a cycle-ergometer(Ergo FIT®, model Ergo 167 Cycle, Pirmasens, Germany) using a computer-based ventilatory expired gas analysis system (VO2000, Medgraphics Corp., St. Paul, MN). All subjects underwent a CPT to determine the peak work rate and the peak oxygen uptake (peak VO2). The subjects' electrocardiographic recordings were monitored using a cardiac monitor, SpO2, BP and sensation of dyspnea and fatigue using the BE-CR-10. A gas analyzer (VO2000 Medgraphics®, St Paul MN, USA) was used to obtain the participants' VO2 at each stage of the test. The ergospirometric values were recorded by the mean value measured every three breaths using the Aerograph® program. The VO2 was determined choosing the higher and more coherent value in the final 30 seconds of each stage.

  • Constant-load exercise test in cycle ergometer and Constant-load exercise test in elliptical equipament: The two exercise tests were performed at 70% of the previously determined work rate in CPT. During the CSET, VO2 was measured breath-by-breath and averaged every three respiration, while SpO2, HR, and the electrocardiogram were continuously monitored, and calculated a on-Kinetics of VO2 and HR.

    * Physical training program:

  • The interval physical training on the elliptical trainer (Kiko's® HM 6022, São Paulo, SP, Brazil) totalized 18 sessions that the individuals of both groups had to attend at least twice a week. Each session lasted not more than 60 minutes and they were all individual meetings. The minimal work rate of the equipment was 40W and the lower increment work rate was 10W. The elliptical trainer allowed combined exercise with the upper limb, however, in the present study, the exercise was performed with the arms fixed, and every participant's HR was monitored using a pulse frequency meter (Polar® FS2cTM Kempele, Finland), the pulse oxygen saturation (SpO2) using a pulse oximeter (Nonin®, model 8500A, Minneapolis, Mn, USA), the blood pressure (BP) using a mercury sphygmomanometer (Oxigel®, São Paulo, SP, Brazil) and the sensation of dyspnea and lower limb fatigue using the Modified Borg CR-10 Scale (BE-CR10). The elliptical exercise was an interval training and was based on studies that performed interval training exercise in cycle ergometer. This was a 30-minute exercise with a rest interval established in one minute. The exercise's work rateworkload was the maximal achieved in the CPT, and it was not modified until the sessions were finished The individuals who did not reach 40W in the CPT performed 30 seconds exercising periods at 40W with 1-minute resting interval. The volunteers who achieved workload equal or higher 40W performed 1-minute exercising periods at the workload achieved in the CPT with 1-minute resting interval. During the exercise on the equipment, the individuals should keep the speed between 40 and 50 rpm.Vital signs (HR, BP, SpO2) were recorded at the beginning and at the end of each session, as well as monitored before, during and after the elliptical exercise. During the training, the vital signs were recorded on the first 30 seconds of each resting interval.
  • The aerobic associate resisted physical training consisted of thirty minutes oa aerobic training at 60-70% of work rate obtained in CPT and subsequently three sets of fifteen repetitions of resistance training in lower limbs on leg press with an intensity of 40-60% of one repetition maximum test.

Study Type

Interventional

Enrollment (Actual)

40

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Brazil
    • Sao Paulo
      • Sao Carlos, Sao Paulo, Brazil, 13565-905
        • Federal University of São Carlos

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

55 years to 80 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Experimental Group:

    • Patients with clinical and spyrometric diagnosis of COPD presenting FEV1/FVC < 70% and FEV1 < 80% predicted by pulmonary function observed and were classified as patients with moderate to very severe obstruction (GOLD, 2010).
    • Clinically stable with no history infection or exacerbation of the respiratory symptoms or change in medication for two months preceding the study.
    • Patients were non oxygen dependent, smokers or former smokers.
    • No subject in the COPD group had ever participated in a pulmonary rehabilitation program (i.e., sedentary during the year preceding admission to the study).
    • Adherence to the individually prescribed treatment regimen.

  • Control Group:

    • Pulmonary Function normal.
    • Subjects in the control group were free of chronic pulmonary, cardiovascular, immune, and metabolic disease.
    • Healthy controls who were sedentary during the year preceding admission to the study.

Exclusion Criteria:

  • Patients with clinical diagnosis of COPD presenting FEV1/FVC ≥ 70% FEV1 ≥ 80% predicted (GOLD, 2010).
  • Malignancy, orthopedic or neurological conditions affecting the ability to exercise, peripheral arterial disease, clinically apparent heart failure, and/or any renal, hepatic or inflammatory disease.
  • Changed the type of medication during the study.
  • Uncontrolled hypertension patients.
  • Peripheral oxygen saturation below 90% at rest.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Interval physical training Control group
Other: Interval physical training in elliptical equipament
Control group (healthy individuals), interval physical training, elliptical equipment, oxygen uptake kinetic, heart rate kinetic.
Other Names:
  • oxygen uptake kinetic,
  • heart rate kinetic.
  • Control group (healthy individuals),
  • interval physical training in elliptical equipment,
Other: Interval physical training in elliptical equipament
COPD, interval physical training, elliptical equipament, oxygen uptake kinetic, heart rate kinetic
Other Names:
  • COPD,
  • oxygen uptake kinetic,
  • heart rate kinetic.
  • interval physical training in elliptical equipament,
Experimental: Resisted/Aerobic physical training group
Other: Resisted/Aerobic physical training
COPD, aerobic physical training in cicloergometer, resisted physical training in cicloergometer, oxygen uptake kinetic, heart rate kinetic.
Other Names:
  • COPD,
  • aerobic physical training in cicloergometer,
  • resisted physical training in cicloergometer,
  • oxygen uptake kinetic,
  • heart rate kinetic.
Other: Resisted/Aerobic physical training
Control group, aerobic physical training in cicloergometer, resisted physical training in leg-press oxygen uptake kinetic heart rate kinetic
Other Names:
  • aerobic physical training in cicloergometer,
  • oxygen uptake kinetic,
  • heart rate kinetic.
  • Control group,
  • resisted physical training in leg-press,
Active Comparator: Aerobic/resisted physical training group
Other: Resisted/Aerobic physical training
COPD, aerobic physical training in cicloergometer, resisted physical training in cicloergometer, oxygen uptake kinetic, heart rate kinetic.
Other Names:
  • COPD,
  • aerobic physical training in cicloergometer,
  • resisted physical training in cicloergometer,
  • oxygen uptake kinetic,
  • heart rate kinetic.
Other: Resisted/Aerobic physical training
Control group, aerobic physical training in cicloergometer, resisted physical training in leg-press oxygen uptake kinetic heart rate kinetic
Other Names:
  • aerobic physical training in cicloergometer,
  • oxygen uptake kinetic,
  • heart rate kinetic.
  • Control group,
  • resisted physical training in leg-press,
Experimental: Interval physical training group
COPD, interval physical training, elliptical equipament, oxygen uptake kinetic, heart rate kinetic
Other: Interval physical training in elliptical equipament
Control group (healthy individuals), interval physical training, elliptical equipment, oxygen uptake kinetic, heart rate kinetic.
Other Names:
  • oxygen uptake kinetic,
  • heart rate kinetic.
  • Control group (healthy individuals),
  • interval physical training in elliptical equipment,
Other: Interval physical training in elliptical equipament
COPD, interval physical training, elliptical equipament, oxygen uptake kinetic, heart rate kinetic
Other Names:
  • COPD,
  • oxygen uptake kinetic,
  • heart rate kinetic.
  • interval physical training in elliptical equipament,

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Effect of aerobic and resisted physical training and interval physical training on oxygen uptake and heart rate on-kinetics in patients with COPD.
Time Frame: baseline and 6 weeks
The kinetic analysis was measured before and after interval physical training and aerobic and resisted physical training by Cardiopulmonary Exercise Testing (CPT; Incremental symptom-limited exercise testing), Constant-load exercise test in cycle ergometer and Constant-load exercise test in elliptical equipament. The on-transient (first 180 seconds) response of VO2 and HR was modeled according to a monoexponencial fit.
baseline and 6 weeks

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in oxygen consumption, minute ventilation, ventilatory limitation, pulmonary carbon dioxide output, metabolic rate.
Time Frame: baseline and 6 weeks
It was evaluated through a MedGraphics VO2000 metabolic system which was operated via computer with Aerograph software and store the signals with the three breath method at the peak of CPT and in the peak of Constant-load exercise test in cycle ergometer and Constant-load exercise test in elliptical equipament before and after interval physical training and aerobic and resisted physical training
baseline and 6 weeks
Change in oxygenation
Time Frame: baseline and 6 weeks
It was evaluated through a Nonin® (modelo 2500, Minneapolis, Mn, USA)wrist pulse oxymeter at the peak of CPT and peak of Constant-load exercise test in cycle ergometer and Constant-load exercise test in elliptical before and after aerobic/resisted physical training and interval physical training in elliptical equipament.
baseline and 6 weeks
Change in heart rate and heart rate reserve
Time Frame: baseline and 6 weeks
It was evaluated through a Polar® cardiofrequency (Polar® FS2cTM Kempele, Finland) at the peak of CPT and peak of Constant-load exercise test in cycle ergometer and Constant-load exercise test in elliptical before and after aerobic/resisted physical training and interval physical training in elliptical equipament.
baseline and 6 weeks
Change in dyspnea and perceived discomfort in lower limbs
Time Frame: baseline and 6 weeks
It was evaluated through a Borg scale (BORG, 1982) at the peak of CPT and peak of Constant-load exercise test in cycle ergometer and Constant-load exercise test in elliptical before and after aerobic/resisted physical training and interval physical training in elliptical equipament.
baseline and 6 weeks
Change in quality of life and Daily Life Activities
Time Frame: baseline and 6 weeks
It was evaluated through a St George's Respiratory Questionnaire (SGRQ) and London Chest Activity of Daily Living Scale (LCADL)(PITTA et al, 2008; CARPES et al, 2008) before and after aerobic/resisted physical training and interval physical training in elliptical equipament.
baseline and 6 weeks
Change in Body composition
Time Frame: baseline and 6 weeks
It was evaluated through a body composition monitor, evaluated weight, body fat percentage, muscle mass free, basal metabolic rate, bone mass and total body water percentage before and after aerobic/resisted physical training and interval physical training in elliptical equipament.
baseline and 6 weeks
Change in BODE Index
Time Frame: baseline and 6 weeks
It was evaluated through multidimensional index comprising of Body Mass Index (BMI), degree of airway obstruction (FEV1), functional dyspnea (MRC dyspnea scale), and exercise capacity by the 6 minute walk test (6MWT). For calculation of the BODE index, we used an empirical model as previously described by Celli et al. (2004), before and after aerobic/ resisted physical training and interval physical training in elliptical equipament.
baseline and 6 weeks
Change in exercise capacity
Time Frame: baseline and 6 weeks
It was evaluated through of performance obtained at the peak of CPT and in the peak of Constant-load exercise test in cycle ergometer and Constant-load exercise test in elliptical equipament before and after interval physical training and aerobic and resisted physical training
baseline and 6 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Universidade Federal de Sao Carlos

Investigators

  • Principal Investigator: Bruna V Pessoa, Ms, Universidade Federal de Sao Carlos

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2008

Primary Completion (Actual)

December 1, 2010

Study Completion (Actual)

December 1, 2011

Study Registration Dates

First Submitted

February 2, 2012

First Submitted That Met QC Criteria

February 6, 2012

First Posted (Estimate)

February 8, 2012

Study Record Updates

Last Update Posted (Estimate)

February 8, 2012

Last Update Submitted That Met QC Criteria

February 6, 2012

Last Verified

February 1, 2012

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • BVPS-123

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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