Study of Intra- and Interpersonal Multimodal Synchronizations in a Social Interaction in Individuals with a Diagnosis of Schizophrenia. (ENHANCER1)

Study of Multimodal Intra- and Interpersonal Synchronizations in Social Interaction in Individuals with a Diagnosis of Schizophrenia.

The aim of this study is to precisely identify deficits in intra- and interpersonal multimodal synchronizations during social interaction in individuals with schizophrenia (ISZ). During a social interaction, individuals use both visual and auditory channels to construct their discourse. The auditory channel encompasses the semantics and prosody of the speech, while the visual channel describes the entirety of non-verbal gestures (e.g., facial expressions, body movements). Prosody and non-verbal gestures are essential elements for the speaker. By accompanying speech, they contribute to the planning and conceptualization of the utterance and enhance its communicative power. For the listener, prosody and non-verbal gestures are also used to provide sensory feedback to the speaker.

Several studies have shown the existence of intrapersonal and interpersonal synchronizations of prosody and non-verbal gestures during interaction. These synchronizations are associated with numerous social benefits (e.g., increased mutual appreciation and quality of interaction). However, certain mental disorders, such as schizophrenia, exhibit deficits in non-verbal behaviors that can impair these synchronizations and the associated social benefits. We hypothetized that interaction with individuals with a daignosis of schizophrenia will be associated with deficits in intra and interpersonal synchronization.

Study Overview

• Status: Recruiting
• Conditions: Schizophrenia
• Intervention / Treatment: Behavioral: Social interaction

Detailed Description

This study includes a pre-inclusion interview followed by a visit to the university hospital (CHU) lasting about 2 hours (including a break). During the visit, the patient participates in an experimental protocol consisting of two parts. In the first part, the patient will be paired with an interaction partner, and the two participants will engage in four distinct conversational tasks, including getting to know each other, free discussions, structured dialogues, and emotional interactions. In the second part, the participants will answer several questionnaires and perform neuropsychological tests in collaboration with an experimenter

• Study Type: Interventional
• Enrollment (Estimated): 120
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Delphine Capdevielle, Pr; Phone Number: 0467339702; Email: d-capdevielle@chu-montpellier.fr
• Study Contact Backup: Name: Mathilde Parisi; Phone Number: 0632935910; Email: mathilde.parisi99@gmail.com

Study Locations

• France
  • Montpellier, France, 34000
    • Recruiting
    • Montpellier University Hospital
    • Contact: Delphine CAPDEVIELLE
    • Contact: Mathilde Parisi; Phone Number: +33467339727; Email: mathilde.parisi99@gmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Individuals with a diagnosis of schizophrenia :

Inclusion Criteria:

• diagnosis of schizophrenia according to the DSM-V
• being able to read, speak and understand french
• giving eclaired consent

Exclusion Criteria:

• history of head trauma
• history of neurological conditions (epilespsy, multiple sclerosis, parkinson's disease, amyotrophic lateral sclerosis, huntington's disease, stroke)
• substance use
• pregnant women

Healthy controls :

Inclusion Criteria:

• being able to read, speak and understand french
• giving eclaired consent

Exclusion Criteria:

• diagnosis of psychosis
• history of head trauma
• history of neurological conditions (epilespsy, multiple sclerosis, parkinson's disease, amyotrophic lateral sclerosis, huntington's disease, stroke)
• substance use
• pregnant women

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: dyad schizophrenia and interacting partner; social interaction between an individual with a diagnosis of schizophrenia and his interacting partner	Behavioral: Social interaction; Participants are required to speak to one another. Participants are given various topics of conversation.
Experimental: dyad healthy subject and interacting partner; social interaction between a healthy subject and his interacting partner	Behavioral: Social interaction; Participants are required to speak to one another. Participants are given various topics of conversation.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
interpersonal synchronization	synchronization between body movements of two interacting partners	4x6 minutes
intrapersonal synchronization	synchronization between voice and body movements of one individual	4x6 minutes

Secondary Outcome Measures

Outcome Measure	Time Frame
correlation between primary outcomes and individuals with schizophrenia medications	4x6 minutes
correlation between synchronization and willingness to continue the interaction	4x6 minutes

Collaborators and Investigators

• Sponsor: University Hospital, Montpellier
• Collaborators: Euromov Digital Health in Motion

Study record dates

Study Major Dates

• Study Start (Actual): November 8, 2024
• Primary Completion (Estimated): November 8, 2025
• Study Completion (Estimated): November 8, 2025

Study Registration Dates

• First Submitted: June 26, 2024
• First Submitted That Met QC Criteria: June 26, 2024
• First Posted (Actual): July 3, 2024

Study Record Updates

• Last Update Posted (Estimated): December 9, 2024
• Last Update Submitted That Met QC Criteria: December 4, 2024
• Last Verified: December 1, 2024

More Information

Terms related to this study

• Keywords: social interaction; interpersonal synchronization
• Additional Relevant MeSH Terms: Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders; Schizophrenia
• Other Study ID Numbers: RECHMPL22_0408

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No