The Immediate Effect of Combined Terminal Knee Extension Exercise With Audible Cues

July 25, 2025 updated by: Komsak Sinsurin, Mahidol University

The Immediate Effect of Combined Terminal Knee Extension Exercise With Audible Cues on Vastus Medialis Muscle Motor Unit Behavior in Healthy Individuals

Typically, patients perform TKE by themselves after exercise prescription. The investigators thought that a lack of attention and preferred speed of patients might not provide the best outcome. Therefore, an increased effectiveness of TKE is interesting for physical therapy implication. Besides, adding sensory input which is audible cues or rhythm during exercise may enhance the efficacy of the exercise by increasing neuromuscular control and function.

Therefore, the study aimed to investigate the immediate effects of combined TKE with audible cues on motor unit behavior. The researchers expect that adding rhythm from the metronome will enhance neuromuscular control which may change motor unit behavior of VM muscle. The findings of the study may have helped explain the mechanism behind the acute effects of combined TKE with audible cues on VM function and their potential application in the field of physical therapy.

This study aims to investigate the immediate effect of combined TKE with audible cues on motor unit behavior in healthy participants and to investigate reliability of decomposition electromyography procedure during single leg squat.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

A metronome will be used to provide rhythmic exercise. Participants will stand with their feet in line with their shoulders as starting position and straping at the knee. Exercise intensity is 60% of the 1RM weight. At the beginning of the exercise, participants will be asked to bend their knees following the pull of the resistance and exert force to straighten the knee (10 times/set and 3 sets). 180 seconds of resting will be allowed between sets.

Study Type

Interventional

Enrollment (Actual)

30

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Thailand
    • Salaya
      • Nakhon Pathom, Salaya, Thailand, 73170
        • Faculty of Physical Therapy, Mahidol University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Aged range between 18 and 30 years
  • BMI of 18.5-25 kg/m2
  • Male or female
  • Lightly active or sedentary {Physical activity level (PAL= 1.4-1.69)}

Exclusion Criteria:

  • History of serious injury or operation of lower back and lower extremities such as fracture
  • Musculoskeletal problems of lower back and lower extremities in 6 months before the study
  • Single-leg stance test < 43 seconds (26). and range of weight-bearing lunge test < 9.1 cm

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Experimental group
Terminal Knee Extension Exercise with Audible Cues
Behavioral: Exercise + Audible Cues
Combined Terminal Knee Extension Exercise with Audible Cues
Other Names:
  • Metronome
Active Comparator: Control group
Terminal Knee Extension Exercise without Audible Cues
Behavioral: Exercise
Terminal Knee Extension Exercise

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Motor unit firing rate
Time Frame: At the end of Cycle 1 (each cycle is 1 day)
one parameter to explain the motor unit behavior of vastus medialis muscle
At the end of Cycle 1 (each cycle is 1 day)
Peak motor action potential
Time Frame: At the end of Cycle 1 (each cycle is 1 day)
one parameter to explain the motor unit behavior of vastus medialis muscle
At the end of Cycle 1 (each cycle is 1 day)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Mahidol University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 10, 2024

Primary Completion (Actual)

February 7, 2025

Study Completion (Actual)

March 7, 2025

Study Registration Dates

First Submitted

August 11, 2024

First Submitted That Met QC Criteria

August 20, 2024

First Posted (Actual)

August 21, 2024

Study Record Updates

Last Update Posted (Actual)

July 29, 2025

Last Update Submitted That Met QC Criteria

July 25, 2025

Last Verified

July 1, 2025

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • MU-CIRB 2024/021.0802

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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