The Immediate Effect of Combined Terminal Knee Extension Exercise With Audible Cues

The Immediate Effect of Combined Terminal Knee Extension Exercise With Audible Cues on Vastus Medialis Muscle Motor Unit Behavior in Healthy Individuals

Typically, patients perform TKE by themselves after exercise prescription. The investigators thought that a lack of attention and preferred speed of patients might not provide the best outcome. Therefore, an increased effectiveness of TKE is interesting for physical therapy implication. Besides, adding sensory input which is audible cues or rhythm during exercise may enhance the efficacy of the exercise by increasing neuromuscular control and function.

Therefore, the study aimed to investigate the immediate effects of combined TKE with audible cues on motor unit behavior. The researchers expect that adding rhythm from the metronome will enhance neuromuscular control which may change motor unit behavior of VM muscle. The findings of the study may have helped explain the mechanism behind the acute effects of combined TKE with audible cues on VM function and their potential application in the field of physical therapy.

This study aims to investigate the immediate effect of combined TKE with audible cues on motor unit behavior in healthy participants and to investigate reliability of decomposition electromyography procedure during single leg squat.

Study Overview

• Status: Completed
• Conditions: Muscle Weakness
• Intervention / Treatment: Behavioral: Exercise + Audible Cues; Behavioral: Exercise

Detailed Description

A metronome will be used to provide rhythmic exercise. Participants will stand with their feet in line with their shoulders as starting position and straping at the knee. Exercise intensity is 60% of the 1RM weight. At the beginning of the exercise, participants will be asked to bend their knees following the pull of the resistance and exert force to straighten the knee (10 times/set and 3 sets). 180 seconds of resting will be allowed between sets.

• Study Type: Interventional
• Enrollment (Actual): 30
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Thailand
  • Salaya
    • Nakhon Pathom, Salaya, Thailand, 73170
      • Faculty of Physical Therapy, Mahidol University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Aged range between 18 and 30 years
• BMI of 18.5-25 kg/m2
• Male or female
• Lightly active or sedentary {Physical activity level (PAL= 1.4-1.69)}

Exclusion Criteria:

• History of serious injury or operation of lower back and lower extremities such as fracture
• Musculoskeletal problems of lower back and lower extremities in 6 months before the study
• Single-leg stance test < 43 seconds (26). and range of weight-bearing lunge test < 9.1 cm

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Experimental group; Terminal Knee Extension Exercise with Audible Cues	Behavioral: Exercise + Audible Cues; Combined Terminal Knee Extension Exercise with Audible Cues; Other Names: Metronome
Active Comparator: Control group; Terminal Knee Extension Exercise without Audible Cues	Behavioral: Exercise; Terminal Knee Extension Exercise

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Motor unit firing rate	one parameter to explain the motor unit behavior of vastus medialis muscle	At the end of Cycle 1 (each cycle is 1 day)
Peak motor action potential	one parameter to explain the motor unit behavior of vastus medialis muscle	At the end of Cycle 1 (each cycle is 1 day)

Collaborators and Investigators

• Sponsor: Mahidol University

Study record dates

Study Major Dates

• Study Start (Actual): February 10, 2024
• Primary Completion (Actual): February 7, 2025
• Study Completion (Actual): March 7, 2025

Study Registration Dates

• First Submitted: August 11, 2024
• First Submitted That Met QC Criteria: August 20, 2024
• First Posted (Actual): August 21, 2024

Study Record Updates

• Last Update Posted (Actual): July 29, 2025
• Last Update Submitted That Met QC Criteria: July 25, 2025
• Last Verified: July 1, 2025

More Information

Terms related to this study

• Keywords: Muscle strength; Therapeutic exercise; Terminal Knee Extension Exercise; Audible Cues
• Additional Relevant MeSH Terms: Neurologic Manifestations; Musculoskeletal Diseases; Nervous System Diseases; Muscular Diseases; Neuromuscular Manifestations; Pathologic Processes; Muscle Weakness
• Other Study ID Numbers: MU-CIRB 2024/021.0802

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No