Effect of Preoperative Exercise Habits on Knee Function and Recurrence Rate After Anterior Cruciate Ligament Reconstruction

The aim of this study is to compare the knee function between patients with and without preoperative exercise habits at 1, 2 and 5 years after ACL surgery, and further analyze the effect of maintaining exercise habits on knee function and recurrence rate

Study Overview

• Status: Recruiting
• Conditions: Anterior Cruciate Ligament Rupture
• Intervention / Treatment: Other: no intervention

Detailed Description

Objective:

1. To compare the knee function between active and inactive patients at 1, 2, and 5 years after ACL surgery.
2. To investigate the difference of knee function and recurrence rate between patients with and without postoperative exercise habit.

Methods: This is a single-center, controlled follow-up cohort study. Inclusion criteria included patients aged 18-45 years with confirmed ACL injury who were scheduled to undergo ACL reconstruction surgery. Exercise habits were recorded before operation, and knee joint function and exercise level were evaluated by questionnaires. All patients received standardized ACL reconstruction surgery and rehabilitation program after surgery. In prospective cohort study, 121 patients were divided into running group and non-running group according to their preoperative exercise habits. At 3 months after surgery, running was included in the rehabilitation program, and the patients were further divided into postoperative running and non-running groups and followed up for one year.In Postoperative cohort study， follow-up was collected and evaluated at 1 year, 2 years and 5 years, including knee function, exercise level and recurrence. The study was divided into four groups: preoperative running group , preoperative non-running group , preoperative and postoperative running group and preoperative non-running and postoperative running group to analyze the effects of preoperative and postoperative exercise habits on knee joint function and recurrence rate. The results of this study will help to deepen the understanding of the impact of preoperative exercise habits and postoperative exercise maintenance on knee function and recurrence rate after ACL reconstruction, and then provide guidance for clinical practice, optimize postoperative rehabilitation programs, and ultimately improve the quality of life of patients.

Subjects: Patients with anterior cruciate ligament rupture in Department of Sports Medicine, Peking University Third Hospital 1.1.1 Inclusion criteria

1. Age of 18-45 years old, male or female.

2. Patients were diagnosed with anterior cruciate ligament injury and planned to undergo anterior cruciate ligament reconstruction surgery 1.1.2 Exclusion criteria Presence of other severe knee disorders (e.g., arthritis).

   • Prior history of other knee surgeries
   • Inability to complete a postoperative rehabilitation program or long-term follow-up.

• Study Type: Observational
• Enrollment (Estimated): 361

Contacts and Locations

• Study Contact: Name: Ruiqin dang; Phone Number: 19261022008; Email: dangruiqin0919@163.com
• Study Contact Backup: Name: Jianquan wang; Phone Number: 13801076267; Email: wjqsportsmed@163.com

Study Locations

• China
  • Beijing
    • Beijing, Beijing, China, 100191
      • Recruiting
      • Peking University Third Hospital
      • Contact: Phone Number: 10822670720

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Probability Sample

Study Population

An ACL injury was diagnosed and an ACL reconstruction surgery was planned

Description

Inclusion Criteria:

• Patients with anterior cruciate ligament rupture in Department of Sports Medicine, Peking University Third Hospital

Exclusion Criteria:

• Severe other knee disorders (e.g., arthritis) are present.
• Prior history of other knee surgeries
• Inability to complete a postoperative rehabilitation program or long-term follow-up

Study Plan

How is the study designed?

Number of groups / cohorts

4

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Preoperative exercise habits group; Moderate-intensity aerobic exercise or strength training was performed at least 3 times per week for 6 months before surgery.	Other: no intervention; no intervention
No exercise habit before operation group; There was no regular exercise habit for 6 months before surgery	Other: no intervention; no intervention
The exercise habit group was maintained after operation; Moderate-intensity aerobic exercise was continued at least three times per week after surgery	Other: no intervention; no intervention
The exercise habit was not maintained after operation; Did not maintain a regular exercise habit after surgery	Other: no intervention; no intervention

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Lysholm knee score	1year，2year，5year
IKDC score	1year，2year，5year
Tegner score	1year，2year，5year
Beighton Score	1year，2year，5year

Secondary Outcome Measures

Outcome Measure	Time Frame
recurrence rate	1year，2year，5year

Collaborators and Investigators

• Sponsor: Peking University Third Hospital

Study record dates

Study Major Dates

• Study Start (Actual): November 30, 2024
• Primary Completion (Estimated): December 31, 2025
• Study Completion (Estimated): December 31, 2025

Study Registration Dates

• First Submitted: September 19, 2024
• First Submitted That Met QC Criteria: September 19, 2024
• First Posted (Actual): September 23, 2024

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: February 10, 2025
• Last Verified: September 1, 2024

More Information

Terms related to this study

• Keywords: anterior cruciate ligament injuries; exercise habit
• Additional Relevant MeSH Terms: Wounds and Injuries; Pathologic Processes; Disease Attributes; Rupture; Recurrence
• Other Study ID Numbers: M2024765

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No