The Role of Lung and Diaphragm Ultrasonography in Predicting Clinical Progression in Hypoxemic Respiratory Failure

The Role of Lung and Diaphragm Ultrasonography in Predicting Clinical Progression in Patients Receiving High-Flow Nasal Oxygen and Non-Invasive Mechanical Ventilation Support for Hypoxemic Respiratory Failure

The goal of this observational study is to evaluate whether the risk of intubation in patients with hypoxemic respiratory failure who were monitored in the intensive care unit and received non-invasive mechanical ventilation and high-flow nasal oxygen treatment could be predicted using lung and diaphragm ultrasound.

The main question it aims to answer is:

Can lung and diaphragm ultrasound predict the risk of intubation in patients with hypoxemic respiratory failure?

Study Overview

• Status: Completed
• Conditions: Hypoxemic Respiratory Failure; Lung Ultrasound; Diaphragm Ultrasonography

Detailed Description

Between January 1, 2024, and May 1, 2024, the diaphragm thickness fraction, excursion, LUS score, ROX index, and the LUSS/ROX index ratio were evaluated using lung and diaphragm ultrasound in 91 patients admitted to the intensive care unit with a diagnosis of hypoxemic respiratory failure. These evaluations were performed at the 6th, 12th, 24th, and 48th hours of their ICU stay, and during intubation if the decision for intubation was made

• Study Type: Observational
• Enrollment (Actual): 91

Contacts and Locations

Study Locations

• Turkey
  • Şişli
    • Istanbul, Şişli, Turkey, 34384
      • Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
    • İstanbul, Şişli, Turkey, 34384
      • Prof. Dr. Cemil Taşcıoğlu City Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Hypoxemic patients in intensive care unit

Description

Inclusion Criteria:

-PaO2 <60 mmHg detected in arterial blood gas samples at the time of admission to the intensive care unit

Exclusion Criteria:

• Under the age of 18
• History of lung and diaphragm surgery
• Congenital, acquired or traumatic diaphragmatic hernia
• Diaphragm paralysis
• Hemodynamic instability requiring vasoactive drug support
• Do not agree to participate in the study

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Hypoxemic; Patients whose partial oxygen levels are low

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Lung and diaphragm ultrasound evaluation for risk of intubation	Lung and diaphragm ultrasound can predict risk of intubation	48 hours

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
ROX index evaluation for risk of intubation	The Respiratory Rate-Oxygenation Index can predict the risk of intubation Higher score means lower risk	48 hours
LUSS/ROX index ratio evaluation for risk of intubation	LUSS/ROX index ratio can predict the risk of intubation	48 hours

Collaborators and Investigators

• Sponsor: Simge Evren
• Investigators: Study Director: Namigar Turgut, Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2024
• Primary Completion (Actual): May 1, 2024
• Study Completion (Actual): August 23, 2024

Study Registration Dates

• First Submitted: November 11, 2024
• First Submitted That Met QC Criteria: November 22, 2024
• First Posted (Estimated): November 27, 2024

Study Record Updates

• Last Update Posted (Estimated): November 27, 2024
• Last Update Submitted That Met QC Criteria: November 22, 2024
• Last Verified: November 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Respiratory Tract Diseases; Respiration Disorders; Respiratory Insufficiency
• Other Study ID Numbers: 291

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No