Pulmonary Artery Doppler in Preeclamptic Mothers

Fetal Pulmonary Artery Doppler in Mothers With Preeclampsia for Detecting Neonatal Respiratory Distress

Evaluation of Pulmonary artery Doppler parameters in fetuses of mothers with severe preeclampsia

Study Overview

• Status: Completed
• Conditions: Pulmonary Artery Doppler
• Intervention / Treatment: Radiation: Pulmonary artery Doppler ultrasound

Detailed Description

Preclampsia (PE) represent a major concern in public health, affecting 2-8% of all pregnancies and considered one of the leading causes of perinatal morbidity and mortality. fetal growth restriction (FGR) ia also a common health problem affecting about 5-10% of all pregnancies and commonly associates with preeclampsia . It is estimated that 20% of cases of PE present with FGR and about 50% of early-onset FGR cases will eventually coexist with PE.

Preeclampsia affects about 5% of pregnancies and hypertensive disorders of pregnancy cause over 60,000 maternal fatalities each year around the world .The decision to deliver a woman with severe pre-eclampsia that is far from the term [mid-trimester] is difficult for the obstetrician.In most cases of highly premature pre-eclamptic gestation, certain institutions propose continuing pregnancy until one of the following occurs development of fetal lung maturity, development of fetal or maternal discomfort, or accomplishment of gestational age of 34 to 36-week of gestation .

Numerous tests have been developed in an attempt to identify if fetal lung maturation has reached a level sufficient to prevent the development of fetal RDS. These tests are based on four core themes: biochemical testing for active surfactant components, biophysical testing for surfactant functionality, physical testing of amniotic fluid opacity, and ultrasound examination of the fetuses and their tissues . Neonatal RDS has been predicted using fetal pulmonary artery Doppler. Kim and colleagues discovered that a high PAT/ET was linked to newborn RDS .The development of RDS in preterm newborns is linked to an increased acceleration time to ejection time [AT/ET] ratio in the fetal pulmonary artery .

• Study Type: Observational
• Enrollment (Actual): 86

Contacts and Locations

Study Locations

• Egypt
  • Asyut, Egypt, 088
    • Women's health hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Pregnant woman with preeclampsia

Description

Inclusion Criteria:

• preeclampsia patients Pregnant 28 -37 weeks

Exclusion Criteria:

• fetal death Congenital fetal anomalies Fetal Cardiac arrhythmia

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort

Intervention / Treatment

Pulmonary artery Doppler; The four chamber view, outflow tract views, triple vessel view, longitudinal view of the aortic arch and ductal arch, and colour flow mapping will be used for a comprehensive examination to assess structural heart integrity and rule out cardiac defects. Pulmonary artery is detected and power Doppler cursor is put on it just beyond pulmonary valve and indices are calculated.

Radiation: Pulmonary artery Doppler ultrasound; Doppler ultrasound of fetal pulmonary artery

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Pulmonary Doppler resistance index	Pulmonary Doppler index in fetus of preeclamptic mother	1 month

Collaborators and Investigators

• Sponsor: Assiut University

Study record dates

Study Major Dates

• Study Start (Actual): December 31, 2024
• Primary Completion (Actual): November 30, 2025
• Study Completion (Actual): December 10, 2025

Study Registration Dates

• First Submitted: December 12, 2024
• First Submitted That Met QC Criteria: December 31, 2024
• First Posted (Actual): January 1, 2025

Study Record Updates

• Last Update Posted (Actual): April 7, 2026
• Last Update Submitted That Met QC Criteria: April 2, 2026
• Last Verified: April 1, 2026

More Information

Terms related to this study

• Keywords: Preeclampsia; Pulmonary Doppler
• Additional Relevant MeSH Terms: Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Pregnancy Complications; Hypertension, Pregnancy-Induced; Pre-Eclampsia
• Other Study ID Numbers: PAD

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No