Post Operative Atrial Fibrillation Post Cardiac Surgery ( CABG and VALVE REPLACEMENT )

Prevelance and Risk Predictors of Post-operative Atrial Fibrillation Among Patients Undergoing Cardiac Surgery At Assiut University Heart Hospital

This study aims to assess the percent and risk factors of postoperative atrial fibrillation in patients undergoing cardiac surgery in Assiut university heart hospital

Study Overview

• Status: Not yet recruiting
• Conditions: Post Operative Atrial Fibrillation

Detailed Description

Arrhythmias are common complications after cardiac surgery, with postoperative atrial fibrillation (POAF) being the most frequently observed arrhythmia. The incidence rate of POAF ranges from 20% to 50%, depending on factors such as the type of surgery, patient population, and criteria used for diagnosis. Notably, POAF has been associated with increased morbidity, mortality, and health care costs. Patients who develop POAF are at a higher risk of experiencing complications such as stroke, heart failure (HF), and prolonged hospital stays. Moreover, POAF has been linked to long-term adverse outcomes, including a greater risk of recurrence of AF/atrial flutter and increased mortality. The accurate prediction of POAF can help guide therapy and facilitate targeted interventions to prevent its occurrence. Early identification of patients at risk for POAF allows for the timely initiation of prophylactic measures, such as the use of β-blockers, amiodarone, or other antiarrhythmic drugs, which have been shown to reduce the incidence of POAF. In this study we are searching for the percent and risk factors of POAF in patients undergoing cardiac surgery in Assiut university hospital.

• Study Type: Observational
• Enrollment (Estimated): 112

Contacts and Locations

• Study Contact: Name: Bahaa Al Moris, Master; Phone Number: +2001225753582; Email: bahaa01225753582@gmail.com
• Study Contact Backup: Name: Beshoy Al Moris, Master; Phone Number: +201288476139; Email: bahaa01225753582@gmail.com

Study Locations

• Egypt
  • Assiut, Egypt, 2063045
    • Faculty of Medicine Assiut University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

1. ≥18 years scheduled for first-time planned cardiac surgery ( CABG and Valve replacement)
2. Patients who are in sinus rhythm and not taking any antiarrhythmic medication, other than beta-adrenergic blocking agents, at the time of surgery.
3. Willingness to participate and provision of informed consent

Description

Inclusion Criteria:

1. ≥18 years scheduled for first-time planned cardiac surgery ( CABG and Valve replacement)
2. Patients who are in sinus rhythm and not taking any antiarrhythmic medication, other than beta-adrenergic blocking agents, at the time of surgery.
3. Willingness to participate and provision of informed consent

Exclusion Criteria:

1. Prior history of cardiac surgery.
2. Pediatric population less than 18 years.
3. Patients with history of hyperthyroidism
4. Patients with electrolyte disturbance
5. Where follow-up is not possible.
6. The patient refused to sign the informed consent to participate in the research.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
First group is patients who developed post operative atrial fibrillation; Patients who developed post operative atrial fibrillation post CABG or valve replacement
Second group is patients who don't develop post operative atrial fibrillation; Patient who don't develop post operative atrial fibrillation post CABG or valve replacement

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Post operative atrial fibrillation	Prevelance of post operative atrial fibrillation in patients undergoing cardiac surgery ( past CABG and valve replacement )	One year

Collaborators and Investigators

• Sponsor: Assiut University
• Investigators: Study Chair: Amr Ah Youssef, M,D, Assiut University Heart Hospital

Publications and helpful links

General Publications

• Villareal RP, Hariharan R, Liu BC, Kar B, Lee VV, Elayda M, Lopez JA, Rasekh A, Wilson JM, Massumi A. Postoperative atrial fibrillation and mortality after coronary artery bypass surgery. J Am Coll Cardiol. 2004 Mar 3;43(5):742-8. doi: 10.1016/j.jacc.2003.11.023.
• Mathew JP, Fontes ML, Tudor IC, Ramsay J, Duke P, Mazer CD, Barash PG, Hsu PH, Mangano DT; Investigators of the Ischemia Research and Education Foundation; Multicenter Study of Perioperative Ischemia Research Group. A multicenter risk index for atrial fibrillation after cardiac surgery. JAMA. 2004 Apr 14;291(14):1720-9. doi: 10.1001/jama.291.14.1720.
• LaPar DJ, Speir AM, Crosby IK, Fonner E Jr, Brown M, Rich JB, Quader M, Kern JA, Kron IL, Ailawadi G; Investigators for the Virginia Cardiac Surgery Quality Initiative. Postoperative atrial fibrillation significantly increases mortality, hospital readmission, and hospital costs. Ann Thorac Surg. 2014 Aug;98(2):527-33; discussion 533. doi: 10.1016/j.athoracsur.2014.03.039.
• Melduni RM, Schaff HV, Bailey KR, Cha SS, Ammash NM, Seward JB, Gersh BJ. Implications of new-onset atrial fibrillation after cardiac surgery on long-term prognosis: a community-based study. Am Heart J. 2015 Oct;170(4):659-68. doi: 10.1016/j.ahj.2015.06.015. Epub 2015 Jun 28.

Study record dates

Study Major Dates

• Study Start (Estimated): January 1, 2025
• Primary Completion (Estimated): January 1, 2026
• Study Completion (Estimated): August 30, 2026

Study Registration Dates

• First Submitted: December 15, 2024
• First Submitted That Met QC Criteria: January 1, 2025
• First Posted (Actual): March 25, 2025

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: January 1, 2025
• Last Verified: January 1, 2025

More Information

Terms related to this study

• Keywords: Cardiac surgery; Post operative atrial fibrillation
• Additional Relevant MeSH Terms: Cardiovascular Diseases; Pathologic Processes; Heart Diseases; Arrhythmias, Cardiac; Atrial Fibrillation
• Other Study ID Numbers: Post operative AF

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No