Predicting Myocardial Infarction After Abdominal Surgery: Clinical Scores & Biomarkers

March 26, 2025 updated by: Mohammed Abd ElRahman Hammed, Benha University

Clinical Scoring and Biomarkers for Prediction of Myocardial Infarction After Non-Cardiac Surgery (MINS) Syndrome in Patients Undergoing Major Abdominal Surgeries

All patients undergoing non-cardiac surgery who met the inclusion criteria underwent a preoperative evaluation using specific assessment tools.

Following surgery, patients were closely monitored in the intermediate care unit for the first 24 hours for the development of acute myocardial infarction (AMI). AMI was diagnosed based on the presence of chest pain, elevated cardiac biomarkers, and specific electrocardiogram (ECG) and echocardiogram findings.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

30

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
    • El Qalyoubia
      • Banhā, El Qalyoubia, Egypt, 13511
        • Benha University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Probability Sample

Study Population

All patients assigned for non-cardiac surgeries who fulfilled the inclusion criteria underwent preoperative evaluation using the assessment tools. All patients were admitted to the intermediate care unit for the 1st 24-h PO for follow-up for the possibility of developing acute myocardial infarction (AMI), which was diagnosed according to the 2017 ESC Guidelines and was differentiated as STEMI and NSTEMI.

Description

Inclusion Criteria:

  • Patients older than 45,
  • Patients of ASA-PS grade II-IV,
  • Patients who prepared for non-cardiac surgeries of SSS of II-IV,
  • Patients free of exclusion criteria,
  • Patients signed the written consent for the study precipitation.

Exclusion Criteria:

  • Patients of ASA-PS grade I or V,
  • Patients younger than 60 years,
  • Patients planned to undergo surgeries of SSS >IV,
  • Patients were severely frail with CFS>6,
  • Patients had abnormal preoperative electrocardiography (ECG),
  • Patients had a history of previous major cardiac or cerebrovascular events,
  • Patient had disturbed cognitive function, coagulopathy, severe anemia with hemoglobin concentration (HBC) < 7 gm/dl.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Myocardial Infarction After Non-Cardiac Surgery (MINS) Syndrome Group
Diagnostic test: 12-lead electrocardiography
All patients were admitted to the intermediate care unit for the 1st 24-h PO for follow-up for the possibility of developing acute myocardial infarction (AMI), which was diagnosed according to the 2017 ESC Guidelines; by 12- lead electrocardiography

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
The proportion of patients reported having at least a 50% incidence of Myocardial Infarction (measured by the Relevant Changes in 12-Leads ECG) in correlation with blood biomarkers.
Time Frame: 50 Days
The incidence of Myocardial infarction after major abdominal surgery detected by relevant changes in 12 leads ECG and in correlation to presence of blood biomarkers
50 Days

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Benha University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

November 15, 2024

Primary Completion (Actual)

January 1, 2025

Study Completion (Actual)

January 31, 2025

Study Registration Dates

First Submitted

January 6, 2025

First Submitted That Met QC Criteria

January 6, 2025

First Posted (Actual)

March 25, 2025

Study Record Updates

Last Update Posted (Actual)

April 1, 2025

Last Update Submitted That Met QC Criteria

March 26, 2025

Last Verified

March 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Rc 6-11-2024

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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