The Effect of Chamomile on Healing After Tooth Extraction

The Effect of Chamomile on Healing After Tooth Extraction: a Retrospective Randomized Controlled Trial

After impacted wisdom tooth extraction, patients frequently complain of pain, edema, and limited mouth opening. After the procedure, patients are routinely recommended to use chlorhexidine and physiological serum-based mouthwashes. The antibacterial and anti-inflammatory effects of warm chamomile tea have been reported in the literature. In addition, the neuroprotective, antiallergic, antioxidant, antiseptic and spasmolytic properties of chamomile have been reported. The aim was to compare the effects of these gargles in terms of pain, mouth opening, burning sensation in the mouth, edema, and discoloration of the tongue and teeth.

Study Overview

• Status: Completed
• Conditions: Tooth Extraction Status Nos
• Intervention / Treatment: Other: Physiological serum mouthwash; Other: Chlorhexidine mouthwash; Other: Chamomile mouthwash

Detailed Description

The study was planned to be applied to 120 patients, 40 in each group. In the ASA 1 group, the mouth opening of the patients was recorded before the tooth extraction procedure. Impacted teeth were extracted using Ultracain D-S Forte (Articaine HCl: 40mg/ml, Epinephrine HCl: 0.012 mg/ml) as a local anesthetic. Dental units were prepared under sterile conditions. The patients were covered with a sterile drape. The lower wisdom tooth was extracted with open (surgical) extraction. The mucoperisoteal flap was lifted with a number 15 surgical scalpel, and the tooth was extracted using round and fissure-tipped steel burs with a handpiece. After tooth extraction, if there was granulation tissue in the extraction socket, it was curetted and irrigated with physiological serum [sodium chloride: 0.009 g/ml, sodium 154 (mEq/I), chloride 154 (mEq/I)]. After bleeding control, patients were given written and verbal postoperative advice. Antibiotics and analgesics were prescribed to patients, chlorhexidine gargle was recommended to 30 patients, saline gargle to 30 patients, and chamomile tea gargle to 30 patients. Patients were given VAS pain scores, numbered 0-10, to record for 7 days after extraction. Patients were called back to the clinic on the 2nd and 7th days after tooth extraction to assess pain, burning sensation and color change in the tongue, mouth opening, and edema. Sutures were removed on the 7th postoperative day.

• Study Type: Interventional
• Enrollment (Actual): 120
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Turkey
  • Unkapani
    • Istanbul, Unkapani, Turkey, 34083
      • Istanbul Medipol University Dental School

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

1. American Society of Anesthesiologists (ASA) physical status I patients,
2. did not have the medical history of being allergic to local anesthesia
3. did not have the medical history of being allergic to CHX,
4. did not have acute infection at the tooth area
5. absence of any pathology at the area.

Exclusion Criteria:

1. Participants with medically compromised condition,
2. pregnant females
3. smokers

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Factorial Assignment
• Masking: Double

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: physiological serum mouthwash group (control group); After extraction, 40 patients were given saline mouthwash to use for 7 days.	Other: Physiological serum mouthwash; Physiological serum contains sodium chloride : 0.009 g/ml, sodium 154 (mEq/I), chloride 154 (mEq/I)].
Active Comparator: chlorhexidine mouthwash group; After extraction, 40 patients were given chlorhexidine mouthwash to use for 7 days.	Other: Chlorhexidine mouthwash; Chlorhexidine mouthwash contains 0.12% chlorhexidine digluconate and 0.15% benzydamine hydrochloride.
Active Comparator: chamomile mouthwash group; After extraction, 40 patients were given chamomile mouthwash to use for 7 days.	Other: Chamomile mouthwash; Chamomile mouthwash contains 10% chamomile in physiological serum.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Patients pain value	visual analog scale (VAS) is used for pain assessment. The patient marked the pain value on the 0-10 visual analog scale.	The patient marked the pain value every day for one week.
maximum mouth opening	maximum mouth openin were measured with the reference of 11 and 41 teeth. are used for interincisal distances	maximum mouth opening was measured preoperatively, postoperative 3rd and 7th days.

Collaborators and Investigators

• Sponsor: reyhansaglam
• Investigators: Principal Investigator: reyhan saglam, PhD, Istanbul Medipol University

Study record dates

Study Major Dates

• Study Start (Actual): March 1, 2019
• Primary Completion (Actual): October 26, 2024
• Study Completion (Actual): October 26, 2024

Study Registration Dates

• First Submitted: January 6, 2025
• First Submitted That Met QC Criteria: January 9, 2025
• First Posted (Actual): March 25, 2025

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: January 9, 2025
• Last Verified: January 1, 2025

More Information

Terms related to this study

• Keywords: chamomile; chlorhexidine; tooth extraction
• Additional Relevant MeSH Terms: Anti-Infective Agents; Anti-Infective Agents, Local; Disinfectants; Chlorhexidine
• Other Study ID Numbers: 10840098-604.01.01-21824

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No