Cerebral and Cognitive Impact of Female Professional SoccerPractice (TCFOOT F)

Cerebral and Cognitive Modifications in Retired Female Professional Soccer Players as Compared to Non Exposed to Repeated Cranial Impacts Sportswomen : Transverse Analytic Study

The objective of this study is to evaluate, using MRI, the microstructural consequences and the onset of any cognitive impairment in female professional soccer players at the end of their career, who have experienced repeated minor head injuries. Over the long term, these head injuries could lead to morphological lesions and have an impact on female soccer players' cognitive skills.

The main evaluation criterion corresponds to the modifications found on MRI in the female professional soccer player group (diffusion tensor, cerebral perfusion, fMRI, cerebral volumetry and cortical thickness, spectroscopy, susceptibility imaging).

This is an exposure/nonexposure study assessing the onset of MRI abnormalities (diffusion tensor, cerebral perfusion, fMRI, volumetry and cortical thickness, spectroscopy, susceptibility imaging) in female professional soccer players exposed to repeated mild head injuries, who are either at the end of their career or retired for approximately 10 years, compared to high-level athletes not exposed to head injuries.

Study Overview

• Status: Not yet recruiting
• Conditions: Traumatic Chronic Encephalopathy
• Intervention / Treatment: Other: Cerebral MRI

• Study Type: Interventional
• Enrollment (Estimated): 80
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Stéphane KREMER, MD; Phone Number: 0033 03 88 12 78 48; Email: stephane.kremer@chru-strasbourg.fr

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Exposed high-level athletes: female professional soccer players at the end of their career (32- years old) playing in France Ligue 1 or 2 exposed to repeated mild head injuries with no history of severe head injury or cerebral
• Female High-level athletes not exposed to repeated mild head injuries: control group paired for age with female professional soccer players, who have never regularly participated in sports exposing them to head injuries (notably rugby, basketball, handball, American football, hockey, combat sports, etc.) and who have no history of head injury, even mild. Female Professional tennis players or former players will be preferentially recruited.

Exclusion Criteria:

• Refusal to be informed of abnormalities on MRI
• Incapacity to give informed consent or under a legal protection order;
• History of cerebral concussion including the presence after head shock of one or more of the following signs or symptoms: a period of confusion or disorientation, a period of loss of consciousness of 30 minutes or less, post-traumatic amnesia not exceeding 24 hours
• History of severe head/brain injury;
• History of neurological or psychiatric disorder;
• Known cerebral abnormality diagnosed by an imaging exam (CT or MRI);
• History or regular or occasional consumption of drugs, unweaned active smoking or weaned for less than 1 year, excessive consumption of alcohol (> 20 g alcohol per day, evaluated with the formula "degree of alcohol × volume in cl × 8/1000"), weaned or not.
• Usage of medication targeting the central nervous system in the 2 weeks preceding inclusion in the study;
• Prior history of severe hypertension, diabetes, chronic heart disease, progressive or disabling disease;
• Contraindication to MRI (claustrophobia, implanted material not compatible with MRI, refusal to be informed of abnormality discovered on MRI)

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Screening
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Female professional Soccer players; Diagnostic Test: MRI The following sequences of the MRI will be acquired during the inclusion visit: 3D T1 gradient echo (GRE): anatomy; registration; cerebral, white matter, and grey matter volumetry; and cortical thickness;; multiecho 3D T2 GRE: quantitative susceptibility mapping (QSM), iron overload quantification;; continuous arterial spin labeling (ASL) 3D: cerebral perfusion;; resting-state fMRI: functional connectivity; -64-direction DTI (b=1000 and 2500): alterations in white matter and its microstructure, anatomic connectivity;; monovoxel spectroscopy of the mesencephalus with short echo time (TE).	Other: Cerebral MRI; Cerebral MRI
Active Comparator: Female athletes not exposed to head injuries.; Diagnostic Test: MRI The following sequences of the MRI will be acquired during the inclusion visit: 3D T1 gradient echo (GRE): anatomy; registration; cerebral, white matter, and grey matter volumetry; and cortical thickness;; multiecho 3D T2 GRE: quantitative susceptibility mapping (QSM), iron overload quantification;; continuous arterial spin labeling (ASL) 3D: cerebral perfusion;; resting-state fMRI: functional connectivity;; 64-direction DTI (b=1000 and 2500): alterations in white matter and its microstructure, anatomic connectivity;; monovoxel spectroscopy of the mesencephalus with short echo time (TE).	Other: Cerebral MRI; Cerebral MRI

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Cerebral MRI Microstructural abnormalities	Abnormalities on MRI in professional soccer players exposed to repeated mild head injuries, potentially related to chronic traumatic encephalopathy, compared to high-level athletes who are not exposed to head injuries. This is a study assessing the relation between exposure to mild head injuries during soccer play in professional players and the onset of MRI and neuropsychological abnormalities. The main evaluation criterion corresponds to the quantitative MRI modifications (professional soccer player group compared with control group).	Day 1

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Neuropsychological abnormalities	The cognitive impact of repeated mild head injuries via a neuropsychological evaluation by neurophysiological tests: number of errors and time to complete tests RL RI 16 items (Van der Linden, 2001) to assess the functioning of verbal episodic memory (= 25 min.) Day 1	day 1
Neuropsychological abnormalities	The cognitive impact of repeated mild head injuries via a neuropsychological evaluation by neurophysiological tests: number of errors and time to complete tests Copy of Rey's complex figure in order to assess episodic visual memory (Rey Osterrieth, 1941) (= 20 min)	Day 1
Neuropsychological abnormalities	The cognitive impact of repeated mild head injuries via a neuropsychological evaluation by neurophysiological tests: number of errors and time to complete tests Verbal and visuo-spatial auditory empans (Wechsler scale Memory form III, 1997) to assess short-term memory and working memory (= 5 min)	Day 1
Neuropsychological abnormalities	The cognitive impact of repeated mild head injuries via a neuropsychological evaluation by neurophysiological tests: number of errors and time to complete tests Copy of Rey's complex figure (Rey-Osterrieth, 1941) assessing visual-constructive abilities and planning (= 5 min)	Day 1
Neuropsychological abnormalities	The cognitive impact of repeated mild head injuries via a neuropsychological evaluation by neurophysiological tests: number of errors and time to complete tests The Brixton Test, a spatial anticipation task that also evaluates executive functioning (Burgess P.W. & Shallice T. (1996) (= 15 min)	Day 1
Neuropsychological abnormalities	The cognitive impact of repeated mild head injuries via a neuropsychological evaluation by neurophysiological tests: number of errors and time to complete tests Trail Making Test A and B (Reitan et al., 1950) assessing treatment speed and mental flexibility (= 5 min)	Day 1
Neuropsychological abnormalities	The cognitive impact of repeated mild head injuries via a neuropsychological evaluation by neurophysiological tests: number of errors and time to complete tests Computerized attention tests will also be used to measure reaction times and also executive aspects (Phasic Alert, Split Attention and Zimmermann APR Incompatibility version 2.1, 2009) (= 15 min)	Day 1
Neuropsychological abnormalities	The cognitive impact of repeated mild head injuries via a neuropsychological evaluation by neurophysiological tests: number of errors and time to complete tests Social cognition test Reading the Mind in the eyes assessing the ability to read the emotions of others which, in turn, is related to pSocial cognition test Reading the Mind in the eyes assessing the ability to read the emotions of others which, in turn, is related to performance in team problem-solving tasks (Baron-Cohen; 2001) ( = 10 min)	Day 1
Neuropsychological abnormalities	The cognitive impact of repeated mild head injuries via a neuropsychological evaluation by neurophysiological tests: number of errors and time to complete tests A BRIEF-A (Behavioural Evaluation Inventory of Executive Functions - Adult Version): 10min	Day 1
Neuropsychological abnormalities	The cognitive impact of repeated mild head injuries via a neuropsychological evaluation by neurophysiological tests: number of errors and time to complete tests Research into recurrent symptoms such as headache (seniority, frequency), fatigability, sleep disturbance, dizziness, blurred vision, photo-phonophobia	Day 1

Collaborators and Investigators

• Sponsor: University Hospital, Strasbourg, France
• Investigators: Principal Investigator: Stéphane KREMER, MD, Hôpitaux Universitaires de Strasbourg

Study record dates

Study Major Dates

• Study Start (Estimated): September 15, 2025
• Primary Completion (Estimated): June 15, 2027
• Study Completion (Estimated): June 15, 2027

Study Registration Dates

• First Submitted: January 16, 2025
• First Submitted That Met QC Criteria: January 16, 2025
• First Posted (Actual): January 23, 2025

Study Record Updates

• Last Update Posted (Actual): August 5, 2025
• Last Update Submitted That Met QC Criteria: August 4, 2025
• Last Verified: August 1, 2025

More Information

Terms related to this study

• Keywords: MRI; neuropsychology; soccer; traumatic chronic encephalopathy; head traumatism
• Additional Relevant MeSH Terms: Central Nervous System Diseases; Nervous System Diseases; Pathologic Processes; Chronic Disease; Disease Attributes; Brain Diseases; Brain Damage, Chronic
• Other Study ID Numbers: 9414

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No