A Comparative Analysis of Preoperative Liver Volumetry in Living Donor Liver Transplantation

March 6, 2025 updated by: Chungnam National University Hospital

Optimizing Accuracy: a Comparative Analysis of Preoperative Liver Volumetry in Living Donor Liver Transplantation from a Surgeon's Perspective

Accurate preoperative graft volume assessment is crucial for successful living donor liver transplantation (LDLT). Although manual and automated computed tomography (CT) volume measurement methods using various volumetric tools are widely used, their accuracy remains uncertain. This study aimed to determine the optimal dry weight correction factor for each method to enhance the prediction of actual graft weight (AGW) and compare the accuracy of different methods.

Study Overview

Status

Completed

Conditions

Detailed Description

This study is a retrospective diagnostic accuracy study comparing three liver volumetry methods using preoperative donor CT scans in LDLT.

Study Type

Observational

Enrollment (Actual)

109

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

This study includes patients who underwent hepatectomy for living donor liver transplantation performed at Chungnam National University Hospital. Data will be retrospectively reviewed to compare preoperative estimated graft volume (EGV) to actual graft weight (AGW).

Description

Inclusion Criteria:

  • Patients who underwent hepatectomy for living donor liver transplantation performed by the Department of Surgery at Chungnam National University Hospital under the supervision of the principal investigator.

Exclusion Criteria:

  • Patients deemed unsuitable for participation in this clinical study by the investigator.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Donors
Patients who received hepatectomy for the living donor liver transplantation.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Accuracy of preoperative estimated graft volume (EGV) compared to actual graft weight (AGW)
Time Frame: From preoperative CT scan (1-2 months before transplantation) to intraoperative measurement (day of transplantation)
The accuracy of preoperative donor CT liver volumetry will be assessed by comparing estimated graft volume (EGV) obtained from three methods (automated, semi-automated, manual) with the actual graft weight (AGW) measured intraoperatively. The error ratio between EGV and AGW will be calculated for each method.
From preoperative CT scan (1-2 months before transplantation) to intraoperative measurement (day of transplantation)

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Determination of the optimal dry weight correction factor for each volumetry method
Time Frame: From preoperative CT scan (1-2 months before transplantation) to intraoperative measurement (day of transplantation)
The study aims to determine the optimal dry weight correction factor by minimizing the discrepancy between EGV and AGW.
From preoperative CT scan (1-2 months before transplantation) to intraoperative measurement (day of transplantation)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Chungnam National University Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

November 1, 2011

Primary Completion (Actual)

December 31, 2024

Study Completion (Actual)

January 31, 2025

Study Registration Dates

First Submitted

March 6, 2025

First Submitted That Met QC Criteria

March 6, 2025

First Posted (Actual)

March 25, 2025

Study Record Updates

Last Update Posted (Actual)

March 25, 2025

Last Update Submitted That Met QC Criteria

March 6, 2025

Last Verified

February 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2024-05-025

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

The data will not be shared publicly due to the retrospective nature of the study and privacy protection concerns.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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